Photothermal treatment of liver cancer with albumin-conjugated gold nanoparticles initiates Golgi Apparatus-ER dysfunction and caspase-3 apoptotic pathway activation by selective targeting of Gp60 receptor

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 5435-5445

  Mocan, Lucian ^a,b   Matea, Cristian ^a   Tabaran, Flaviu A ^c   Mosteanu, Ofelia ^a,b   Pop, Teodora ^a,b   Mocan, Teodora ^a,b   Iancu, Cornel ^a,b  

^a Regional Institute of Gastroenterology and Hepatology Octavian Fodor   (Romania)

^b IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c UNIVERSITY OF AGRICULTURAL SCIENCES AND VETERINARY MEDICINE   (Romania)

Author keywords

Albumin; Functionalization; Gold nanoparticles; HepG2 cells; Laser irradiation; Liver cancer

Indexed keywords

CASPASE 3; GLYCOPROTEIN; GLYCOPROTEIN 60 RECEPTOR; GOLD NANOPARTICLE; LIPOCORTIN 5; SERUM ALBUMIN; UNCLASSIFIED DRUG; CASP3 PROTEIN, HUMAN; DRUG CARRIER; GOLD; METAL NANOPARTICLE; SIALOGLYCOPROTEIN; SIALOGLYCOPROTEIN GP60;

ALBUMIN BLOOD LEVEL; APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER CELL; CELL CULTURE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; GOLGI COMPLEX; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IRRADIATION; LIVER CANCER; LIVER CELL; PHOTOTHERAPY; PHOTOTHERMAL THERAPY; CHEMISTRY; DRUG EFFECTS; HEP-G2 CELL LINE; LASER; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NECROSIS; PATHOLOGY; PHOTOCHEMISTRY; THERMOTHERAPY;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; DRUG CARRIERS; ENDOPLASMIC RETICULUM; GOLD; GOLGI APPARATUS; HEP G2 CELLS; HUMANS; HYPERTHERMIA, INDUCED; IMMUNOHISTOCHEMISTRY; LASERS; LIVER NEOPLASMS; METAL NANOPARTICLES; NECROSIS; PHOTOCHEMISTRY; SERUM ALBUMIN; SIALOGLYCOPROTEINS;

EID: 84940050544     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S86495     Document Type: Article

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