Restrictive blood transfusion strategies and associated infection in orthopedic patients: A meta-analysis of 8 randomized controlled trials

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Teng, Zhaowei ^a   Zhu, Yun ^a   Liu, Yugang ^b   Wei, Guojun ^c   Wang, Shuangneng ^a   Du, Shaoliang ^a   Zhang, Xiguang ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF ENGINEERING   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; BACTERIAL INFECTIONS; BLOOD TRANSFUSION; COMORBIDITY; EVIDENCE BASED MEDICINE; FEMALE; HUMAN; INCIDENCE; INTERNATIONAL COOPERATION; MALE; META ANALYSIS; MIDDLE AGED; ORTHOPEDIC SURGERY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; STATISTICS AND NUMERICAL DATA; SURGICAL WOUND INFECTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; BLOOD TRANSFUSION; COMORBIDITY; EVIDENCE-BASED MEDICINE; FEMALE; HUMANS; INCIDENCE; INTERNATIONALITY; MALE; MIDDLE AGED; ORTHOPEDIC PROCEDURES; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; SURGICAL WOUND INFECTION;

EID: 84940029783     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13421     Document Type: Article

References (29)

1. Takei, T., Amin, N. A., Schmid, G., Dhingra-Kumar, N., Rugg, D. Progress in global blood safety for HIV. J. Acquir. Immune Defic. Syndr. 52 Suppl 2, S127-131 (2009).
2. US Department of Health & Human Services. The 2009 National Blood Collection and Utilization Survey Report (US Department of Health and Human Services. Office of the Assistant Secretary for Health, Washington, DC, 2011).
3. Cobain, T., Vamvakas, E., Wells, A., Titlestad, K. A survey of the demographics of blood use. Transfus. Med. 17, 1-15 (2007).
4. Carson, J. L. et al. Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial. Lancet 385, 1183-1189 (2015).
5. Williams III, L. A., Snyder, E. L. Transfusion-related adverse events. in Reference Module in Biomedical Sciences (Elsevier, 2014).
6. Parker, M. J. Randomised trial of blood transfusion versus a restrictive transfusion policy after hip fracture surgery. Injury 44, 1916-1918 (2013).
7. Gruber-Baldini, A. L. et al. Delirium outcomes in a randomized trial of blood transfusion thresholds in hospitalized older adults with hip fracture. J. Am. Geriatr. Soc. 61, 1286-1295 (2013).
8. Fan, Y. X. et al. Comparison of restrictive and liberal transfusion strategy on postoperative delirium in aged patients following total hip replacement: a preliminary study. Arch. Gerontol. Geriatr. 59, 181-185 (2014).
9. Grover, M. et al. Silent myocardial ischaemia and haemoglobin concentration: a randomized controlled trial of transfusion strategy in lower limb arthroplasty. Vox Sang. 90, 105-112 (2006).
10. Carson, J. L., Carless, P. A., Hebert, P. C. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev. 4, CD002042, doi: 10.1002/14651858.CD002042.pub3 (2012).
11. Rohde, J. M. et al. Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis. JAMA. 311, 1317-1326 (2014).
12. So-Osman, C. et al. A randomized comparison of transfusion triggers in elective orthopaedic surgery using leucocyte-depleted red blood cells. Vox Sang. 98, 56-64 (2010).
13. Salpeter, S. R., Buckley, J. S., Chatterjee, S. Impact of more restrictive blood transfusion strategies on clinical outcomes: a metaanalysis and systematic review. Am. J. Med. 127, 124-131 e123 (2014).
14. Carson, J. L. et al. Liberal or restrictive transfusion in high-risk patients after hip surgery. N. Engl. J. Med. 365, 2453-2462 (2011).
15. Hebert, P. C., McDonald, B. J., Tinmouth, A. Clinical consequences of anemia and red cell transfusion in the critically ill. Crit. Care Clin. 20, 225-235 (2004).
16. Napolitano, L. M., Corwin, H. L. Efficacy of red blood cell transfusion in the critically ill. Crit. Care Clin. 20, 255-268 (2004).
17. Cata, J., Wang, H., Gottumukkala, V., Reuben, J., Sessler, D. Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br. J. Anaesth. 110, 690-701 (2013).
18. Carson, J. L. et al. A pilot randomized trial comparing symptomatic vs. hemoglobin-level-driven red blood cell transfusions following hip fracture. Transfusion 38, 522-529 (1998).
19. Foss, N. B. et al. The effects of liberal versus restrictive transfusion thresholds on ambulation after hip fracture surgery. Transfusion 49, 227-234 (2009).
20. Bernard, A. C., Davenport, D. L., Chang, P. K., Vaughan, T. B., Zwischenberger, J. B. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J. Am. Coll. Surg. 208, 931-937 e932 (2009).
21. Carson, J. et al. Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 39, 694-700 (1999).
22. Fergusson, D., Khanna, M. P., Tinmouth, A., Hebert, P. C. Transfusion of leukoreduced red blood cells may decrease postoperative infections: two meta-analyses of randomized controlled trials. Can. J. Anesth. 51, 417-424 (2004).
23. Jadad, A. R. et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control. Clin. Trials 17, 1-12 (1996).
24. DerSimonian, R., Laird, N. Meta-analysis in clinical trials. Control. Clin. Trials 7, 177-188 (1986).
25. Higgins, J., Thompson, S. G., Deeks, J. J., Altman, D. G. Measuring inconsistency in meta-analyses. BMJ. 327, 557-560 (2003).
26. Mantel, N., Haenszel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22, 719-748 (1959).
27. Poulos, J., Kam, P. "Number needed to treat": a tool for summarizing treatment effect, and its application in anaesthesia and pain management. Curr. Anaesth. Crit. Care 16, 173-179 (2005).
28. Harbord, R. M., Egger, M., Sterne, J. A. A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat. Med. 25, 3443-3457 (2006).
29. Begg, C. B., Mazumdar, M. Operating characteristics of a rank correlation test for publication bias. Biometrics 50, 1088-1101 (1994).