Increased morbidity in early childhood among HIV-exposed uninfected children in uganda is associated with breastfeeding duration

Journal of Tropical Pediatrics

Volumn 60, Issue 6, 2014, Pages 434-441

  Marquez, Carina ^a,e   Okiring, Jaffer ^b   Chamie, Gabriel ^a   Ruel, Theodore D ^a   Achan, Jane ^c   Kakuru, Abel ^b   Kamya, Moses R ^c   Charlebois, Edwin D ^d   Havlir, Diane V ^a   Dorsey, Grant ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INFECTIOUS DISEASES RESEARCH COLLABORATION   (Uganda)

^c MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES   (Uganda)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Africa; Breastfeeding; HIV; HIV exposed; Morbidity; Mortality

Indexed keywords

COTRIMOXAZOLE;

AGE; ARTICLE; BREAST FEEDING; CHILD; CHILDHOOD; CHILDHOOD MORTALITY; COHORT ANALYSIS; DIARRHEA; DISEASE SEVERITY; FEMALE; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS EXPOSED UNINFECTED CHILDREN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS UNEXPOSED UNINFECTED CHILDREN; INFANT; INFECTION RISK; MAJOR CLINICAL STUDY; MALARIA; MALE; MALNUTRITION; MISCELLANEOUS NAMED GROUPS; MORBIDITY; MOTHER; OUTCOME ASSESSMENT; PARALLEL DESIGN; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SECONDARY ANALYSIS; UGANDA; COMPARATIVE STUDY; HIV INFECTIONS; NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRESCHOOL CHILD; RURAL POPULATION; SOCIOECONOMICS; STATISTICS AND NUMERICAL DATA; TRANSMISSION; VERTICAL TRANSMISSION; WEANING;

BREAST FEEDING; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DIARRHEA; FEMALE; HIV INFECTIONS; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; MORBIDITY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; RURAL POPULATION; SOCIOECONOMIC FACTORS; UGANDA; WEANING;

EID: 84940017729     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fmu045     Document Type: Article

References (23)

1. Filteau S. The HIV-exposed, uninfected African child. Trop Med Int Health 2009;14:276-87.
2. Nakiyingi JS, Bracher M, Whitworth JA, et al. Child survival in relation to mother's HIV infection and survival: evidence from a Ugandan cohort study. AIDS 2003;17:1827-34.
3. Ng'weshemi J, Urassa M, Isingo R, et al. HIV impact on mother and child mortality in rural Tanzania. J Acquir Immune Defic Syndr 2003;33:393-404.
4. Shapiro RL, Lockman S, Kim S, et al. Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana. J Infect Dis 2007;196:562-9.
5. Landes M, van Lettow M, Chan AK, et al. Mortality and health outcomes of HIV-exposed and unexposed children in a PMTCT cohort in Malawi. PloS One 2012;7:e47337.
6. Clerici M, Saresella M, Colombo F, et al. T-lymphocyte maturation abnormalities in uninfected newborns and children with vertical exposure to HIV. Blood 2000;96:3866-71.
7. Mazzola TN, da Silva MTN, Abramczuk BM, et al. Impaired bacillus calmette-guérin cellular immune response in HIV-exposed, uninfected infants. AIDS 2011;25:2079-87.
8. Farquhar C, Nduati R, Haigwood N, et al. High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody. J Acquir Immune Defic Syndr 2005;40:494-7.
9. Jones CE, Naidoo S, De Beer C, et al. Maternal HIV infection and antibody responses against vaccine-preventable diseases in uninfected infants. JAMA 2011;305:576-84. doi:10.1001/jama.2011.100.
10. World Health Organization. Programmatic Update: Use of Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants. Geneva, Switzerland: World Health Organization, 2012.
11. Homsy J, Moore D, Barasa A, et al. Breastfeeding, mother-to-child hiv transmission, and mortality among infants born to hiv-infected women on highly active antiretroviral therapy in rural uganda. J Acquir Immune Defic Syndr 2010;53:28-35.
12. Asbjörnsdóttir KH, Slyker JA, Weiss NS, et al. Breastfeeding is associated with decreased pneumonia incidence among HIV-exposed, uninfected Kenyan infants. AIDS 2013;27:2809-15.
13. Kourtis AP, Wiener J, Kayira D, et al. Health outcomes of HIV-exposed uninfected African infants. AIDS 2013;27:749-59.
14. Taha TE, Hoover DR, Chen S, et al. Effects of cessation of breastfeeding in HIV-1-exposed, uninfected children in Malawi. Clin Infect Dis 2011;53:388-95.
15. Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality. Lancet 2000;355:451-5.
16. Kuhn L, Sinkala M, Semrau K, et al. Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers. Clin Infect Dis 2010;50:437-44.
17. Okello PE, Van Bortel W, Byaruhanga AM, et al. Variation in malaria transmission intensity in seven sites throughout Uganda. Am J Trop Med Hyg 2006;75:219-25.
18. WHO | Guidelines on HIV and infant feeding 2010. WHO. http://www.who.int/maternal_child_adolescent/ documents/9789241599535/en/. (9 December 2013, date last accessed).
19. WHO | Recommendations for management of common childhood conditions. WHO. http://www.who.int/ maternal_child_adolescent/documents/management_ch ildhood_conditions/en/index.html. (18 February 2014, date last accessed).
20. Osterbauer B, Kapisi J, Bigira V, et al. Factors associated with malaria parasitaemia, malnutrition, and anaemia among HIV-exposed and unexposed Ugandan infants: a cross-sectional survey. Malar J 2012;11:432.
21. Taha TE, Dadabhai SS, Rahman MH, et al. Trends in birth weight and gestational age for infants born to HIV-infected, antiretroviral treatment-naive women in Malawi. Pediatr Infect Dis J 2012;31:481-6.
22. Owor M, Mwatha A, Donnell D, et al. Long-term follow-up of children in the HIVNET 012 perinatal HIV prevention trial: five-year growth and survival. J Acquir Immune Defic Syndr 2013;64:464-71.
23. Arpadi S, Fawzy A, Aldrovandi GM, et al. Growth faltering due to breastfeeding cessation in uninfected children born to HIV-infected mothers in Zambia. Am J Clin Nutr 2009;90:344-53.