A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis

Neurotherapeutics

Volumn 12, Issue 2, 2015, Pages 455-460

  Sanders, Donald B ^a   Rosenfeld, Jeffrey ^b   Dimachkie, Mazen M ^c   Meng, Lisa ^d   Malik, Fady I ^d   Andrews, Jinsy ^d   Barohn, Richard ^c   Corse, Andrea ^e   Deboo, Anahita ^f   Felice, Kevin ^g   Harati, Yadollah ^h   Heiman Patterson, Terry ^f   Howard, James F ⁱ   Jackson, Carlayne ^j   Juel, Vern ^k   Katz, Jonathan ^l   Lee, Jacqueline ^d   Massey, Janice ^k   McVey, April ^c   Mozaffar, Tahseen ^m   Pasnoor, Mamatha ^c   Small, George ⁿ   So, Yuen ^o   Wang, Annabel K ^m   Weinberg, David ^p   Wolff, A Andrew ^d   more..

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^d Cytokinetics Inc   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^h BAYLOR COLLEGE OF MEDICINE   (United States)

ⁱ UNIVERSITY OF NORTH CAROLINA   (United States)

^j UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^k DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ ALLEGHENY HEALTH NETWORK   (United States)

^o STANFORD UNIVERSITY   (United States)

^p Neurocare Center for Research   (United States)

more..

Author keywords

CK 2017357; fast skeletal troponin activator; Myasthenia gravis; tirasemtiv

Indexed keywords

CHOLINERGIC RECEPTOR; CK-2017357; IMIDAZOLE DERIVATIVE; PROTEIN BINDING; PYRAZINE DERIVATIVE;

ADOLESCENT; ADULT; AGED; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; MYASTHENIA GRAVIS; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMIDAZOLES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MYASTHENIA GRAVIS; OUTCOME ASSESSMENT (HEALTH CARE); PROTEIN BINDING; PYRAZINES; RECEPTORS, CHOLINERGIC; YOUNG ADULT;

EID: 84940006623     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-015-0345-y     Document Type: Article

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