Porcine hepcidin exerts an iron-independent bacteriostatic activity against pathogenic bacteria

International Journal of Peptide Research and Therapeutics

Volumn 21, Issue 2, 2015, Pages 229-236

  Liu, Dan ^a   Pu, Yutian ^a   Xiong, Haitao ^a   Wang, Yizhen ^a   Du, Huahua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Antimicrobial peptide; Bacteriostatic activity; Iron; Porcine hepcidin

Indexed keywords

EID: 84940002087     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-014-9451-7     Document Type: Article

References (25)

1. Alvarez CA, Guzman F, Cardenas C, Marshall SH, Mercado L (2014) Antimicrobial activity of trout hepcidin. Fish Shellfish Immun 41:93-101
2. Braun V, Hantke K (2011) Recent insights into iron import by bacteria. Curr Opin Chem Biol 15:328-334
3. Campopiano DJ, Clarke DJ, Polfer NC, Barran PE, Langley RJ, Govan JRW (2004) Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity. J Biol Chem 279:48671-48679
4. Clark RJ, Tan CC, Preza GC, Nemeth E, Ganz T, Craik DJ (2011) Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chem Biol 18:336-343
5. Ganz T (2003) Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102:783-788
6. Ganz T (2006) Hepcidin: a peptide hormone at the interface of innate immunity and iron metabolism. Curr Top Microbiol Immunol 306:183-198
7. Ganz T (2008) Iron homeostasis: fitting the puzzle pieces together. Cell Metab 7:288-290
8. Hocquellet A, Senechal CL, Garbay B (2012) Importance of the disulfide bridges in the antibacterial activity of human hepcidin. Peptides 36:303-307
9. Kacprzyk L, Rydengard V, Morgelin M, Davoudi M, Pasupuleti M, Malmsten M, Schmidtchen A (2007) Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions. Biochim Biophys Acta 1768:2667-2680
10. Koliaraki V, Marinou M, Samiotaki M, Panayotou G, Pantopoulos K, Mamalaki A (2008) Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris. Biochimie 90:726-735
11. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K (2000) LEAP-1, a novel highly disulfide bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480:147-150
12. Kristensen LH, Knapp KM, Franzyk H, Gram L (2013) Selectivity in the potentiation of antibacterial activity of α -peptide/β-peptoid peptidomimetics and antimicrobial peptides by human blood plasma. Res Microbiol 164:933-940
13. Lipinski P, Starzynski RR, Canonne-Hergaux F, Tudek B, Olinski R (2010) Benefits and risks of iron supplementation in anemic neonatal pigs. Am J Pathol 177:1233-1243
14. Liu YF, Xia X, Xu L, Wang YZ (2013) Design of hybrid β-hairpin peptides with enhanced cell specificity and potent anti-inflammatory activity. Biomaterials 34:237-250
15. Maartje DV, Lianqiang C, Veronique H, Sofie W, Christophe C, Steven VC, Chris VG (2013) Increased IGF-1 serum levels and discordant protein and mRNA IGF-1 receptor expression in the small intestine of formula-fed piglets. Livest Sci 154:224-228
16. Maisetta G, Batoni G, Esin S, Florio W, Bottai D, Favilli F (2006) In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains. Antimicrob Agents Ch 50:806-809
17. Maisetta G, Luca MD, Esin S, Florio W, Brancatisano FL, Bottai D, Campa M, Batoni G (2008) Evaluation of the inhibitory effects of human serum components on bactericidal activity of human beta defensin 3. Peptides 29:1-6
18. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-2093
19. Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810
20. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276:7811-7819
21. Sang Y, Blecha F (2009) Porcine host defense peptides: expanding repertoire and functions. Dev Comp Immunol 33:334-343
22. Sang Y, Ramanathan B, Minton JE, Ross CR, Blecha F (2006) Porcine liver-expressed antimicrobial peptides, hepcidin and LEAP-2: cloning and induction by bacterial infection. Dev Comp Immunol 30:357-366
23. Shi JS, Camus AC (2006) Hepcidins in amphibians and fishes: antimicrobial peptides or iron-regulatory hormones? Dev Comp Immunol 30:746-755
24. Starzynski RR, Laarakkers CMM, Tjalsma H, Swinkels DW, Pieszka M, Stys A, Mickiewicz M, Lipinski P (2013) Iron supplementation in suckling piglets: how to correct iron deficiency anemia without affecting plasma hepcidin levels. PLoS ONE 8:e64022
25. Yeaman MR, Yount NY (2003) Mechanisms of antimicrobial peptide action and resistance. Pharmacol Rev 55:27-55