Bcl-2 Phosphorylation Triggers Autophagy Switch and Reduces Mitochondrial Damage in Limb Remote Ischemic Conditioned Rats After Ischemic Stroke

Translational Stroke Research

Volumn 6, Issue 3, 2015, Pages 198-206

  Qi, Zhifeng ^a,b   Dong, Wen ^a,b   Shi, Wenjuan ^a,b   Wang, Rongliang ^a,b   Zhang, Chencheng ^a,b   Zhao, Yongmei ^a,b   Ji, Xunming ^a,b   Liu, Ke Jian ^a,c   Luo, Yumin ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Autophagy; Bcl 2; Cerebral ischemia; Conditioning; Mitochondria

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, RAT; ONCOPROTEIN; PROTEIN BCL 2;

ANIMAL; AUTOPHAGY; BRAIN; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; FEMORAL ARTERY; ISCHEMIC POSTCONDITIONING; MALE; METABOLISM; MITOCHONDRION; PHOSPHORYLATION; RAT; SPRAGUE DAWLEY RAT; VASCULARIZATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BRAIN; BRAIN ISCHEMIA; FEMORAL ARTERY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC POSTCONDITIONING; MALE; MITOCHONDRIA; ONCOGENE PROTEIN V-AKT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84939995251     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-015-0393-y     Document Type: Article

References (26)

1. Chen F, Qi Z, Luo Y, Hinchliffe T, Ding G, Xia Y, et al. Non-pharmaceutical therapies for stroke: mechanisms and clinical implications. Prog Neurobiol. 2014;115:246–69.
2. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, et al. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79:1853–61.
3. Sun J, Tong L, Luan Q, Deng J, Li Y, Li Z, et al. Protective effect of delayed remote limb ischemic postconditioning: role of mitochondrial K(ATP) channels in a rat model of focal cerebral ischemic reperfusion injury. J Cereb Blood Flow Metab. 2012;32:851–9.
4. Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, et al. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012;43:2794–9.
5. Hahn CD, Manlhiot C, Schmidt MR, Nielsen TT, Redington AN. Remote ischemic per-conditioning: a novel therapy for acute stroke? Stroke. 2011;42:2960–2.
6. Qi ZF, Luo YM, Liu XR, Wang RL, Zhao HP, Yan F, Song ZJ, Luo M, Ji XM. AKT/GSK3beta-dependent autophagy contributes to the neuroprotection of limb remote ischemic postconditioning in the transient cerebral ischemic rat model. CNS Neurosci Ther. 2012;28:965–73.
7. Zhao H. Ischemic postconditioning as a novel avenue to protect against brain injury after stroke. J Cereb Blood Flow Metab. 2009;29:873–85.
8. Hougaard KD, Hjort N, Zeidler D, Sorensen L, Norgaard A, Hansen TM, et al. Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke. 2014;45:159–67.
9. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368:651–62.
10. Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature. 2011;469:323–35.
11. Cheong H, Lu C, Lindsten T, Thompson CB. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol. 2012;30:671–8.
12. Metcalf DJ, Garcia-Arencibia M, Hochfeld WE, Rubinsztein DC. Autophagy and misfolded proteins in neurodegeneration. Exp Neurol. 2012;238:22–8.
13. Moran M, Moreno-Lastres D, Marin-Buera L, Arenas J, Martin MA, Ugalde C. Mitochondrial respiratory chain dysfunction: implications in neurodegeneration. Free Radic Biol Med. 2012;53:595–609.
14. Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy. 2008;4:600–6.
15. Sun K, Xie X, Liu Y, Han Z, Zhao X, Cai N, et al. Autophagy lessens ischemic liver injury by reducing oxidative damage. Cell Biosci. 2013;3:26.
16. Zhang X, Yan H, Yuan Y, Gao J, Shen Z, Cheng Y, et al. Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance. Autophagy. 2013;9:1321–33.
17. Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015;1852:243–51.
18. Qi Z, Yang W, Liu Y, Cui T, Gao H, Duan C, et al. Loss of PINK1 function decreases PP2A activity and promotes autophagy in dopaminergic cells and a murine model. Neurochem Int. 2011;59:572–81.
19. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221:3–12.
20. Kubota C, Torii S, Hou N, Saito N, Yoshimoto Y, Imai H, et al. Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biol Chem. 2010;285:667–74.
21. Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. 2012;8:77–87.
22. Maiuri MC, Zalckvar E, Kimchi A, Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8:741–52.
23. Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy. 2007;3:374–6.
24. Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell. 2008;30:678–88.
25. Srinivasan S, Avadhani NG. Cytochrome c oxidase dysfunction in oxidative stress. Free Radic Biol Med. 2012;53:1252–63.
26. Tait SW, Green DR. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol. 2010;11:621–32.