Incidence and Risk Factors for Hepatocellular Carcinoma in Primary Biliary Cirrhosis

Clinical Reviews in Allergy and Immunology

Volumn 48, Issue 2-3, 2015, Pages 132-141

  Rong, Guanghua ^a   Wang, Hong ^a   Bowlus, Christopher L ^b   Wang, Chunping ^a   Lu, Yinying ^a   Zeng, Zhen ^a   Qu, Jianhui ^a   Lou, Min ^a   Chen, Yan ^a   An, Linjing ^a   Yang, Yongping ^a   Gershwin, M Eric ^c  

^a BEIJING 302 HOSPITAL   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Geoepidemiology; HBV; Hepatocellular carcinoma; Primary biliary cirrhosis

Indexed keywords

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; COMPLICATION; FEMALE; FOLLOW UP; HUMAN; INCIDENCE; LIVER CIRRHOSIS, BILIARY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MORTALITY; RETROSPECTIVE STUDY; RISK FACTOR; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; LIVER CIRRHOSIS, BILIARY; LIVER NEOPLASMS; MALE; MIDDLE AGED; MORTALITY; RETROSPECTIVE STUDIES; RISK FACTORS; TUMOR BURDEN;

EID: 84939990871     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-015-8483-x     Document Type: Article

References (40)

1. Huang W, Kachapati K, Adams D et al (2014) Murine autoimmune cholangitis requires two hits: cytotoxic KLRG1(+) CD8 effector cells and defective T regulatory cells. J Autoimmun 50:123–134
2. Liaskou E, Hirschfield GM, Gershwin ME (2014) Mechanisms of tissue injury in autoimmune liver diseases. Semin Immunopathol 36:553–568
3. Wang L, Sun Y, Zhang Z et al (2015) CXCR5 CD4 T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis. Hepatology 61:627–638
4. Yang CY, Ma X, Tsuneyama K et al (2014) IL-12/Th1 and IL-23/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy. Hepatology 59:1944–1953
5. Yao Y, Yang W, Yang YQ et al (2014) Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Ralpha(-/-) mice. J Autoimmun 51:99–108
6. Zhang J, Zhang W, Leung PS et al (2014) Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis. Hepatology 60:1708–1716
7. Lleo A, Zhang W, McDonald WH et al (2014) Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells. Hepatology 60:1314–1323
8. Selmi C, Bowlus CL, Gershwin ME, Coppel RL (2011) Primary biliary cirrhosis. Lancet 377:1600–1609
9. Fattovich G, Stroffolini T, Zagni I, Donato F (2004) Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127:S35–S50
10. Trivedi PJ, Lammers WJ, van Buuren HR et al (2015) Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study. Gut. doi:10.1136/gutjnl-2014-308351
11. Cavazza A, Caballería L, Floreani A et al (2009) Incidence, risk factors, and survival of hepatocellular carcinoma in primary biliary cirrhosis: comparative analysis from two centers. Hepatology 50:1162–1168
12. Harada K, Hirohara J, Ueno Y et al (2013) Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: national data from Japan. Hepatology 57:1942–1949
13. Teuber G, Schaefer A, Berger A et al (2010) Previous hepatitis B virus (HBV) infection is a strong risk factor for the severity of inflammatory activity and the extent of fibrosis in patients with chronic hepatitis C. Hepatology 52:1236A
14. Tanaka K, Nagao Y, Ide T, Kumashiro R, Sata M (2006) Antibody to hepatitis B core antigen is associated with the development of hepatocellular carcinoma in hepatitis C virus-infected persons: a 12-year prospective study. Int J Mol Med 17:827–832
15. Ohba K, Kubo S, Tamori A et al (2004) Previous or occult hepatitis B virus infection in hepatitis B surface antigen-negative and anti-hepatitis C-negative patients with hepatocellular carcinoma. Surg Today 34:842–848
16. Marusawa H, Osaki Y, Kimura T et al (1999) High prevalence of anti-hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan. Gut 45:284–288
17. Ikeda K, Marusawa H, Osaki Y et al (2007) Antibody to hepatitis B core antigen and risk for hepatitis C-related hepatocellular carcinoma. A prospective study. Ann Intern Med 146:649–656
18. Ikeda K, Kobayashi M, Someya T et al (2009) Occult hepatitis B virus infection increases hepatocellular carcinogenesis by eight times in patients with non-B, non-C liver cirrhosis: a cohort study. J Viral Hepat 16:437–443
19. Adachi S, Shibuya A, Miura Y, Takeuchi A, Nakazawa T, Saigenji K (2008) Impact of occult hepatitis B virus infection and prior hepatitis B virus infection on development of hepatocellular carcinoma in patients with liver cirrhosis due to hepatitis C virus. Scand J Gastroenterol 43:849–856
20. Lu J, Zhou Y, Lin X et al (2009) General epidemiological parameters of viral hepatitis A, B, C, and E in six regions of China: a cross-sectional study in 2007. PLoS One 4:e8467
21. Gao J, Xie L, Yang WS et al (2012) Risk factors of hepatocellular carcinoma—current status and perspectives. Asian Pac J Cancer Prev 13:743–752
22. Bogdanos DP, Komorowski L (2011) Disease-specific autoantibodies in primary biliary cirrhosis. Clin Chim Acta 412:502–512
23. Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ (2009) Primary biliary cirrhosis. Hepatology 50:291–308
24. Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208–1236
25. Forner A, Reig ME, de Lope CR, Bruix J (2010) Current strategy for staging and treatment: the BCLC update and future prospects. Semin Liver Dis 30:061–074
26. Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association (2010) Guidelines for diagnosis and treatment for alcoholic liver diseases. Chin J Clin Hepatol 2:49–53
27. Granito A, Yang W-H, Muratori L et al (2009) PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis. Am J Gastroenterol 105:125–131
28. Ishibashi H, Komori A, Shimoda S, Ambrosini YM, Gershwin ME, Nakamura M (2011) Risk factors and prediction of long-term outcome in primary biliary cirrhosis. Intern Med 50:1–10
29. Findor J, He X-S, Sord J, Terg R, Gershwin ME (2002) Primary biliary cirrhosis and hepatocellular carcinoma. Autoimmun Rev 1:220–225
30. Macaron C, Hanouneh IA, Zein NN (2010) Incidence and risk factors of hepatocellular carcinoma in patients with primary biliary cirrhosis. Hepatology 52:2240
31. Zaman SN, Melia WM, Johnson RD, Portmann BC, Johnson PJ, Williams R (1985) Risk factors in development of hepatocellular carcinoma in cirrhosis: prospective study of 613 patients. Lancet 1:1357–1360
32. Caballeria L, Pares A, Castells A, Gines A, Bru C, Rodes J (2001) Hepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus-related cirrhosis. Am J Gastroenterol 96:1160–1163
33. Farinati F, Floreani A, De Maria N, Fagiuoli S, Naccarato R, Chiaramonte M (1994) Hepatocellular carcinoma in primary biliary cirrhosis. J Hepatol 21:315–316
34. Bréchot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Bréchot P (2001) Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: clinically significant or purely “occult”? Hepatology 34:194–203
35. Raimondo G, Pollicino T, Cacciola I, Squadrito G (2007) Occult hepatitis B virus infection. J Hepatol 46:160–170
36. Bréchot C (2004) Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: old and new paradigms. Gastroenterology 127:S56–S61
37. Lok AS, Sterling RK, Everhart JE et al (2010) Des-γ-carboxy prothrombin and α-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma. Gastroenterology 138:493–502
38. Trevisani F, D'Intino PE, Morselli-Labate AM et al (2001) Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34:570–575
39. Shibuya A, Tanaka K, Miyakawa H et al (2002) Hepatocellular carcinoma and survival in patients with primary biliary cirrhosis. Hepatology 35:1172–1178
40. Kuiper EM, Hansen BE, Adang RP et al (2010) Relatively high risk for hepatocellular carcinoma in patients with primary biliary cirrhosis not responding to ursodeoxycholic acid. Eur J Gastroenterol Hepatol 22:1495–1502