GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: Are 5-HT5B receptors involved?

Journal of Cardiovascular Pharmacology

Volumn 65, Issue 4, 2015, Pages 335-341

  Sánchez Maldonado, Carolina ^a   López Sánchez, Pedro ^b   Anguiano Robledo, Liliana ^b   Leopoldo, Marcello ^c   Lacivita, Enza ^c   Terrón, José A ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c UNIVERSITY OF BARI   (Italy)

Author keywords

5 HT1B 1D receptors; 5 HT5A 5B receptors; Anesthetized rats; Hypotension; Systemic blood vessels

Indexed keywords

3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL] 1,1 DIPHENYL 2 PROPANOL; 5-CARBOXAMIDOTRYPTAMINE; BIPHENYL DERIVATIVE; ERGOTAMINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; OXADIAZOLE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERIDONE DERIVATIVE; SB 22489G; SEROTONIN; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SPIRO COMPOUND;

ANALOGS AND DERIVATIVES; ANIMAL; BLOOD PRESSURE; DISEASE MODEL; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECTS; GENETICS; HYPOTENSION; METABOLISM; RAT;

ANIMALS; BIPHENYL COMPOUNDS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; ERGOTAMINE; HYPOTENSION; OXADIAZOLES; PIPERAZINES; PIPERIDONES; RATS; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN RECEPTOR AGONISTS; SPIRO COMPOUNDS;

EID: 84939963175     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000200     Document Type: Article

References (21)

1. De Vries P, Villalon CM, Heiligers JP, et al. Nature of 5-HT1-like receptors mediating depressor responses in vagosympathectomized rats: close resemblance to the cloned 5-ht7 receptor. Naunyn-schmiedebergs Arch Pharmacol. 1997;356:90-99.
2. 7 receptors in the long-lasting hypotensive response induced by 5-hydroxytryptamine in the rat. Br J Pharmacol. 1997;121:563-571.
3. Skingle M, Beattie DT, Scopes DIC, et al. GR127935: a potent and selective 5-HT1D receptor antagonist. Behav Brain Res. 1996;73:157-161.
4. Terrón JA, Sánchez-Maldonado C, Martínez-García E. Pharmacological evidence that 5-HT(1B/1D) receptors mediate hypotension in anesthetized rats. Eur J Pharmacol. 2007;576:132-135.
5. 7 receptor-mediated dilatation in the middle meningeal artery of anesthetized rats. Eur J Pharmacol. 2007;560:56-60.
6. Balasubramaniam G, Lee HS, Mah SC. Antihypertensive effect of chronic i.v. administration of 5-carboxamidotryptamine in spontaneously hypertensive rats. Eur J Pharmacol. 1993;237:207-213.
7. Balasubramaniam G, Lee HS, Mah SC. 5-Carboxamidotryptamine attenuates the development of deoxycorticosterone acetate-salt hypertension in rats. Eur J Pharmacol. 1995;276:183-190.
8. Erlander MG, Lovenberg TW, Baron BM, et al. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proc Natl Acad Sci U S A. 1993;90:3452-3456.
9. Matthes H, Boschert U, Amlaiky N, et al. Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. Mol Pharmacol. 1993;43:313-319.
10. Plassat JL, Boschert U, Amlaiky N, et al. The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family. EMBO J. 1992;11:4779-4786.
11. Thomas DR, Soffin EM, Roberts C, et al. SB-699551-A (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4'-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl] propanamidedihydrochloride), a novel 5-ht5A receptor-selective antagonist, enhances 5-HT neuronal function: evidence for an autoreceptor role for the 5-ht5A receptor in guinea pig brain. Neuropharmacology. 2006;51:566-577.
12. Leopoldo M, Berardi F, Colabufo NA, et al. Structure - affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1- piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J Med Chem. 2004;47:6616-6624.
13. Lovell PJ, Bromidge SM, Dabbs S, et al. A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrroli-dine-1-sulfonyl) phenol (SB-269970). J Med Chem. 2000;43:342-345.
14. Hoyer D, Clarke DE, Fozard JR, et al. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev. 1994;46:157-203.
15. Lovenberg TW, Baron BM, de Lecea L, et al. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993;11:449-458.
16. González-Hernández A, Muñoz-Islas E, Lozano-Cuenca J, et al. Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats. Eur J Pharmacol. 2010;637:131-137.
17. Goadsby PJ, Classey JD. Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience. 2003;122:491-498.
18. Sánchez-López A, Centurion D, Vazquez E, et al. Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br J Pharmacol. 2003;140:725-735.
19. Curtin PC, Medan V, Neumeister H, et al. The 5-HT5A receptor regulates excitability in the auditory startle circuit: functional implications for sensorimotor gating. J Neurosci. 2013;33:10011-10020.
20. Gonzalez R, Chávez-Pascacio K, Meneses A. Role of 5-HT5A receptors in the consolidation of memory. Behav Brain Res. 2013;252:246-251.
21. Wesołowska A. The anxiolytic-like effect of the selective 5-HT6 receptor antagonist SB-399885: the impact of benzodiazepine receptors. Eur J Pharmacol. 2008;580:355-360.