miR-153 inhibits epithelial–mesenchymal transition by targeting metadherin in human breast cancer

Breast Cancer Research and Treatment

Volumn 150, Issue 3, 2015, Pages 501-509

  Li, Wentong ^a   Zhai, Limin ^a   Zhao, Chunling ^a   Lv, Shijun ^a  

^a WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; EMT; Invasion; miR 153; MTDH

Indexed keywords

CELL ADHESION MOLECULE; MICRORNA; MIRN153 MICRORNA, HUMAN; MTDH PROTEIN, HUMAN;

ADULT; AGED; BREAST TUMOR; CELL MOTION; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MCF 7 CELL LINE; MIDDLE AGED; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ADULT; AGED; BREAST NEOPLASMS; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; MICRORNAS; MIDDLE AGED; NEOPLASM INVASIVENESS;

EID: 84939955524     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-015-3346-y     Document Type: Article

References (21)

1. Creighton CJ, Gibbons DL, Kurie JM (2013) The role of epithelial–mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Manag Res 5:187–195
2. Brabletz T (2012) To differentiate or not–routes towards metastasis. Nat Rev Cancer 12(6):425–436
3. Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q (2011) Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis 32(1):2–9
4. Xia X, Du R, Zhao L, Sun W, Wang X (2014) Expression of AEG-1 and microvessel density correlates with metastasis and prognosis of oral squamous cell carcinoma. Hum Pathol 45(4):858–865
5. Lee SG, Su ZZ, Emdad L, Sarkar D, Franke TF, Fisher PB (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27(8):1114–1121
6. Yoo BK, Emdad L, Su ZZ, Villanueva A, Chiang DY, Mukhopadhyay ND, Mills AS, Waxman S, Fisher RA, Llovet JM et al (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Investig 119(3):465–477
7. Di Leva G, Croce CM (2013) The role of microRNAs in the tumorigenesis of ovarian cancer. Front Oncol 3:153
8. Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celia-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y et al (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 17(9):1101–1108
9. Xu Q, Sun Q, Zhang J, Yu J, Chen W, Zhang Z (2013) Downregulation of miR-153 contributes to epithelial–mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis 34(3):539–549
10. Dong R, Liu X, Zhang Q, Jiang Z, Li Y, Wei Y, Yang Q, Liu J, Wei JJ, Shao C et al (2014) miR-145 inhibits tumor growth and metastasis by targeting metadherin in high-grade serous ovarian carcinoma. Oncotarget 5(21):10816–10829
11. Tang Y, Liu X, Su B, Zhang Z, Zeng X, Lei Y, Shan J, Wu Y, Tang H, Su Q (2014) microRNA-22 acts as a metastasis suppressor by targeting metadherin in gastric cancer. Mol Med Rep 11(1):454–460
12. Hu G, Chong RA, Yang Q, Wei Y, Blanco MA, Li F, Reiss M, Au JL, Haffty BG, Kang Y (2009) MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15(1):9–20
13. Heckman KL, Pease LR (2007) Gene splicing and mutagenesis by PCR-driven overlap extension. Nat Protoc 2(4):924–932
14. Bullock MD, Sayan AE, Packham GK, Mirnezami AH (2012) MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biology of the cell/under the auspices of the European Cell Biology Organization 104(1):3–12
15. Gregory PA, Bracken CP, Bert AG, Goodall GJ (2008) MicroRNAs as regulators of epithelial–mesenchymal transition. Cell Cycle 7(20):3112–3118
16. Mongroo PS, Rustgi AK (2010) The role of the miR-200 family in epithelial–mesenchymal transition. Cancer Biol Ther 10(3):219–222
17. Peter ME (2009) Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle 8(6):843–852
18. Zhang N, Wang X, Huo Q, Sun M, Cai C, Liu Z, Hu G, Yang Q (2014) MicroRNA-30a suppresses breast tumor growth and metastasis by targeting metadherin. Oncogene 33(24):3119–3128
19. Kim TH, Kim YK, Kwon Y, Heo JH, Kang H, Kim G, An HJ (2010) Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. Histopathology 57(5):734–743
20. Xu J, Liao X, Wong C (2010) Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis in a glioblastoma cell line DBTRG-05MG. Int J Cancer 126(4):1029–1035
21. Nohata N, Hanazawa T, Kikkawa N, Mutallip M, Sakurai D, Fujimura L, Kawakami K, Chiyomaru T, Yoshino H, Enokida H et al (2011) Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC). J Hum Genet 56(8):595–601