Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Neurochemistry International

Volumn 83-84, Issue , 2015, Pages 28-40

  Fjær, Sveinung ^a,b   Bø, Lars ^a,b   Myhr, Kjell Morten ^a,b   Torkildsen, Oivind ^a,b   Wergeland, Stig ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Animal models; EAE; MTR; Multiple sclerosis; Myelin

Indexed keywords

ANIMAL; BRAIN; C57BL MOUSE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FEMALE; INFLAMMATION; METABOLISM; MYELIN SHEATH; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PROCEDURES;

ANIMALS; BRAIN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MICE, INBRED C57BL; MYELIN SHEATH;

EID: 84939954392     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.02.006     Document Type: Article

References (41)

1. Agosta F., Rovaris M., Pagani E., Sormani M.P., Comi G., and Filippi M. Magnetization transfer MRI metrics predict the accumulation of disability 8 years later in patients with multiple sclerosis Brain 129 Pt 10 2006 2620 2627 10.1093/brain/awl208 http://dx.doi.org/10.1093/brain/awl208
2. Aharoni R., Sasson E., Blumenfeld-Katzir T., Eilam R., Sela M., and Assaf Y. Magnetic resonance imaging characterization of different experimental autoimmune encephalomyelitis models and the therapeutic effect of glatiramer acetate Exp. Neurol 240 2013 130 144 10.1016/j.expneurol.2012.11.004 http://dx.doi.org/10.1016/j.expneurol.2012.11.004
3. Bagnato F., Hametner S., and Welch E.B. Visualizing iron in multiple sclerosis Magn. Reson. Imaging 31 3 2013 376 384 10.1016/j.mri.2012.11.011 http://dx.doi.org/10.1016/j.mri.2012.11.011
4. Berger C., Hiestand P., Kindler-Baumann D., Rudin M., and Rausch M. Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitis by visualization of macrophage infiltration, demyelination and blood-brain barrier damage NMR Biomed 19 1 2006 101 107 10.1002/nbm.1007 http://dx.doi.org/10.1002/nbm.1007
5. Blezer E.L.A., Bauer J., Brok H.P.M., Nicolay K., and 't Hart B.A. Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis NMR Biomed 20 2 2007 90 103 10.1002/nbm.1085 http://dx.doi.org/10.1002/nbm.1085
6. Boretius S., Escher A., Dallenga T., Wrzos C., Tammer R., and Brück W. Assessment of lesion pathology in a new animal model of ms by multiparametric MRI and DTI Neuroimage 59 3 2012 2678 2688 10.1016/j.neuroimage.2011.08.051 http://www.sciencedirect.com/science/article/pii/S1053811911009682
7. Boss A., Oppitz M., Wehrl H.F., Rossi C., Feuerstein M., and Claussen C.D. Measurement of t1, t2, and magnetization transfer properties during embryonic development at 7 Tesla using the chicken model J. Magn. Reson. Imaging 28 6 2008 1510 1514 10.1002/jmri.21601 http://dx.doi.org/10.1002/jmri.21601
8. Cook L.L., Foster P.J., Mitchell J.R., and Karlik S.J. In vivo 4.0-t magnetic resonance investigation of spinal cord inflammation, demyelination, and axonal damage in chronic-progressive experimental allergic encephalomyelitis J. Magn. Reson. Imaging 20 4 2004 563 571 10.1002/jmri.20171 http://dx.doi.org/10.1002/jmri.20171
9. Day M. Histopathology of eae Lavi E. Constantinescu C. Experimental Models of Multiple Sclerosis, Springer US 2005 25 43 10.1007/0-387-25518-4 http://dx.doi.org/10.1007/0-387-25518-4
10. Dousset V., Grossman R.I., Ramer K.N., Schnall M.D., Young L.H., and Gonzalez-Scarano F. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging Radiology 182 2 1992 483 491 http://dx.doi.org/10.1148/radiology.182.2.1732968
11. Dousset V., Gayou A., Brochet B., and Caille J.M. Early structural changes in acute ms lesions assessed by serial magnetization transfer studies Neurology 51 4 1998 1150 1155 10.1212/WNL.51.4.1150
12. Filippi M., Campi A., Dousset V., Baratti C., Martinelli V., and Canal N. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis Neurology 45 3 Pt 1 1995 478 482 10.1212/WNL.45.3.478
13. Filippi M., Rocca M.A., and Comi G. Magnetization transfer ratios of multiple sclerosis lesions with variable durations of enhancement J. Neurol. Sci 159 2 1998 162 165 10.1016/S0022-510X(98)00162-2
14. Fjær S., Bø L., Lundervold A., Myhr K.-M., Pavlin T., and Torkildsen O. Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model PLoS ONE 8 12 2013 e84162 10.1371/journal.pone.0084162 http://dx.doi.org/10.1371/journal.pone.0084162
15. Gareau P.J., Rutt B.K., Karlik S.J., and Mitchell J.R. Magnetization transfer and multicomponent t2 relaxation measurements with histopathologic correlation in an experimental model of ms J. Magn. Reson. Imaging 11 6 2000 586 595 10.1002/1522-2586(200006)11:6<586::aid-jmri3>3.0.CO;2-V
16. Grossman R.I. Magnetization transfer in multiple sclerosis Ann. Neurol 36 Suppl. 1994 S97 S99 10.1002/ana.410360722
17. Hametner S., Wimmer I., Haider L., Pfeifenbring S., Brück W., and Lassmann H. Iron and neurodegeneration in the multiple sclerosis brain Ann. Neurol 74 6 2013 848 861 10.1002/ana.23974 http://dx.doi.org/10.1002/ana.23974
18. Kuerten S., Kostova-Bales D.A., Frenzel L.P., Tigno J.T., Tary-Lehmann M., and Angelov D.N. Mp4- and mog:35-55-induced eae in c57bl/6 mice differentially targets brain, spinal cord and cerebellum J. Neuroimmunol 189 1-2 2007 31 40 10.1016/j.jneuroim.2007.06.016 http://dx.doi.org/10.1016/j.jneuroim.2007.06.016
19. Laule C., Vavasour I.M., Leung E., Li D.K.B., Kozlowski P., and Traboulsee A.L. Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology Mult. Scler 17 2 2011 144 150 10.1177/1352458510384008 http://dx.doi.org/10.1177/1352458510384008
20. Mackenzie-Graham A., Rinek G.A., Avedisian A., Gold S.M., Frew A.J., and Aguilar C. Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging Neuroimage 60 1 2011 95 104 10.1016/j.neuroimage.2011.11.099 http://dx.doi.org/10.1016/j.neuroimage.2011.11.099
21. Martens M.H., Lambregts D.M.J., Papanikolaou N., Heijnen L.A., Riedl R.G., and zur Hausen A. Magnetization transfer ratio: a potential biomarker for the assessment of postradiation fibrosis in patients with rectal cancer Invest. Radiol 49 1 2014 29 34 10.1097/RLI.0b013e3182a3459b http://dx.doi.org/10.1097/RLI.0b013e3182a3459b
22. Merkler D., Boretius S., Stadelmann C., Ernsting T., Michaelis T., and Frahm J. Multicontrast MRI of remyelination in the central nervous system NMR Biomed 18 6 2005 395 403 10.1002/nbm.972 http://dx.doi.org/10.1002/nbm.972
23. Mottershead J.P., Schmierer K., Clemence M., Thornton J.S., Scaravilli F., and Barker G.J. High field MRI correlates of myelin content and axonal density in multiple sclerosis-a post-mortem study of the spinal cord J. Neurol 250 11 2003 1293 1301 10.1007/s00415-003-0192-3 http://dx.doi.org/10.1007/s00415-003-0192-3
24. Mueggler T., Pohl H., Baltes C., Riethmacher D., Suter U., and Rudin M. MRI signature in a novel mouse model of genetically induced adult oligodendrocyte cell death Neuroimage 59 2 2012 1028 1036 10.1016/j.neuroimage.2011.09.001 http://dx.doi.org/10.1016/j.neuroimage.2011.09.001
25. Orr E.L., Aschenbrenner J.E., Oakford L.X., Jackson F.L., and Stanley N.C. Changes in brain and spinal cord water content during recurrent experimental autoimmune encephalomyelitis in female lewis rats Mol. Chem. Neuropathol 22 3 1994 185 195 10.1007/BF03160105
26. Papanikolaou N., Ghiatas A., Kattamis A., Ladis C., Kritikos N., and Kattamis C. Non-invasive myocardial iron assessment in thalassaemic patients. t2 relaxometry and magnetization transfer ratio measurements Acta Radiol 41 4 2000 348 351 10.1080/028418500127345442
27. Rausch M., Hiestand P., Baumann D., Cannet C., and Rudin M. MRI-based monitoring of inflammation and tissue damage in acute and chronic relapsing eae Magn. Reson. Med 50 2 2003 309 314 10.1002/mrm.10541 http://dx.doi.org/10.1002/mrm.10541
28. Rausch M., Tofts P., Lervik P., Walmsley A., Mir A., and Schubart A. Characterization of white matter damage in animal models of multiple sclerosis by magnetization transfer ratio and quantitative mapping of the apparent bound proton fraction f Mult. Scler 15 1 2009 16 27 10.1177/1352458508096006 http://dx.doi.org/10.1177/1352458508096006
29. Schmierer K., Scaravilli F., Altmann D.R., Barker G.J., and Miller D.H. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain Ann. Neurol 56 3 2004 407 415 10.1002/ana.20202 http://dx.doi.org/10.1002/ana.20202
30. Schmierer K., Tozer D.J., Scaravilli F., Altmann D.R., Barker G.J., and Tofts P.S. Quantitative magnetization transfer imaging in postmortem multiple sclerosis brain J. Magn. Reson. Imaging 26 1 2007 41 51 10.1002/jmri.20984 http://dx.doi.org/10.1002/jmri.20984
31. Schmierer K., Parkes H.G., So P.-W., An S.F., Brandner S., and Ordidge R.J. High field (9.4 Tesla) magnetic resonance imaging of cortical grey matter lesions in multiple sclerosis Brain 133 Pt 3 2010 858 867 10.1093/brain/awp335 http://dx.doi.org/10.1093/brain/awp335
32. Schuh C., Wimmer I., Hametner S., Haider L., Van Dam A.-M., and Liblau R.S. Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models Acta Neuropathol 128 2 2014 247 266 10.1007/s00401-014-1263-5 http://dx.doi.org/10.1007/s00401-014-1263-5
33. Serres S., Anthony D.C., Jiang Y., Broom K.A., Campbell S.J., and Tyler D.J. Systemic inflammatory response reactivates immune-mediated lesions in rat brain J. Neurosci 29 15 2009 4820 4828 10.1523/JNEUROSCI.0406-09.2009 http://dx.doi.org/10.1523/JNEUROSCI.0406-09.2009
34. Serres S., Anthony D.C., Jiang Y., Campbell S.J., Broom K.A., and Khrapitchev A. Comparison of MRI signatures in pattern i and ii multiple sclerosis models NMR Biomed 22 10 2009 1014 1024 10.1002/nbm.1404 http://dx.doi.org/10.1002/nbm.1404
35. Serres S., Bristow C., de Pablos R.M., Merkler D., Soto M.S., and Sibson N.R. Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis J. Cereb. Blood Flow Metab 33 5 2013 744 753 10.1038/jcbfm.2013.12 http://dx.doi.org/10.1038/jcbfm.2013.12
36. Smith S.A., Bulte J.W.M., and van Zijl P.C.M. Direct saturation MRI: theory and application to imaging brain iron Magn. Reson. Med 62 2 2009 384 393 10.1002/mrm.21980 http://dx.doi.org/10.1002/mrm.21980
37. Syha R., Springer F., Grözinger G., Würslin C., Ipach I., and Ketelsen D. Short-term exercise-induced changes in hydration state of healthy Achilles tendons can be visualized by effects of off-resonant radiofrequency saturation in a three-dimensional ultrashort echo time MRI sequence applied at 3 Tesla J. Magn. Reson. Imaging 40 6 2014 1400 1407 10.1002/jmri.24488 http://dx.doi.org/10.1002/jmri.24488
38. van Waesberghe J.H., Kamphorst W., De Groot C.J., van Walderveen M.A., Castelijns J.A., and Ravid R. Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights into substrates of disability Ann. Neurol 46 5 1999 747 754 10.1002/1531-8249(199911)46:5<747::aid-ana10>3.0.CO;2-4
39. Vavasour I.M., Li D.K.B., Laule C., Traboulsee A.L., Moore G.R.W., and Mackay A.L. Multi-parametric mr assessment of t(1) black holes in multiple sclerosis: evidence that myelin loss is not greater in hypointense versus isointense t(1) lesions J. Neurol 254 12 2007 1653 1659 10.1007/s00415-007-0604-x http://dx.doi.org/10.1007/s00415-007-0604-x
40. Vavasour I.M., Laule C., Li D.K.B., Traboulsee A.L., and MacKay A.L. Is the magnetization transfer ratio a marker for myelin in multiple sclerosis? J. Magn. Reson. Imaging 33 3 2011 713 718 10.1002/jmri.22441 http://dx.doi.org/10.1002/jmri.22441
41. Zaaraoui W., Deloire M., Merle M., Girard C., Raffard G., and Biran M. Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 t MAGMA 21 5 2008 357 362 10.1007/s10334-008-0141-3 http://dx.doi.org/10.1007/s10334-008-0141-3