Carvedilol improves biventricular fibrosis and function in experimental pulmonary hypertension

Journal of Molecular Medicine

Volumn 93, Issue 6, 2015, Pages 663-674

  Okumura, Kenichi ^a   Kato, Hideyuki ^a   Honjo, Osami ^a   Breitling, Siegfried ^b   Kuebler, Wolfgang M ^b   Sun, Mei ^a   Friedberg, Mark K ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Adrenergic receptor blocker; Pulmonary arterial hypertension; Right heart dysfunction; Ventricular ventricular interactions

Indexed keywords

ANTIHYPERTENSIVE AGENT; CARBAZOLE DERIVATIVE; CARVEDILOL; CONNECTIVE TISSUE GROWTH FACTOR; PROPANOLAMINE DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL; DRUG EFFECTS; FIBROSIS; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HEMODYNAMICS; HYPERTENSION, PULMONARY; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CARBAZOLES; CONNECTIVE TISSUE GROWTH FACTOR; FIBROSIS; HEART VENTRICLES; HEMODYNAMICS; HYPERTENSION, PULMONARY; MALE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84939951116     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-015-1251-9     Document Type: Article

References (28)

1. Kitaori K, He H, Ayres SM, Kawata M, Cowan DB, Friehs I, del Nido PJ, McGowan FX (2009) Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy. Circ Heart Fail 2:599–607
2. Handoko ML, de Man FS, Allaart CP, Paulus WJ, Westerhof N, Vonk-Noordegraaf A (2010) Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart. Eur Respir Rev 19:72–82
3. Gan CT, Lankhaar JW, Marcus JT, Westerhof N, Marques KM, Bronzwaer JG, Boonstra A, Postmus PE, Vonk-Noordegraaf A (2006) Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 290:H1528–H1533
4. Alkon J, Humpl T, Manlhiot C, McCrindle BW, Reyes JT, Friedberg MK (2010) Usefulness of the right ventricular systolic to diastolic duration ratio to predict functional capacity and survival in children with pulmonary arterial hypertension. Am J Cardiol 106:430–436
5. Friedberg MK, Cho MY, Li J, Assad RS, Sun M, Rohailla S, Honjo O, Apitz C, Redington AN (2013) Adverse biventricular remodeling in isolated right ventricular hypertension is mediated by increased TGFbeta1 signaling and is abrogated by angiotensin receptor blockade. Am J Respir Cell Mol Biol 49:1019–1028
6. Apitz C, Honjo O, Humpl T, Li J, Assad RS, Cho MY, Hong J, Friedberg MK, Redington AN (2012) Biventricular structural and functional responses to aortic constriction in a rabbit model of chronic right ventricular pressure overload. J Thoracic Cardiovasc Surg 144:1494–1501
7. Nootens M, Kaufmann E, Rector T, Toher C, Judd D, Francis GS, Rich S (1995) Neurohormonal activation in patients with right ventricular failure from pulmonary hypertension: relation to hemodynamic variables and endothelin levels. J Am Coll Cardiol 26:1581–1585
8. Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, Chau VQ, Hoke NN, Kraskauskas D, Kasper M, Salloum FN et al (2010) Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Crit Care Med 82:652–660
9. Tei C, Dujardin KS, Hodge DO, Bailey KR, McGoon MD, Tajik AJ, Seward SB (1996) Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr 9:838–847
10. Duan Y, Harada K, Wu W, Ishii H, Takada G (2008) Correlation between right ventricular Tei index by tissue Doppler imaging and pulsed Doppler imaging in fetuses. Pediatr Cardiol 29:739–743
11. Fukuda Y, Tanaka H, Sugiyama D, Ryo K, Onishi T, Fukuya H, Nogami M, Ohno Y, Emoto N, Kawai H et al (2011) Utility of right ventricular free wall speckle-tracking strain for evaluation of right ventricular performance in patients with pulmonary hypertension. J Am Soc Echocardiogr 24:1101–1108
12. Koopman LP, Slorach C, Manlhiot C, McCrindle BW, Jaeggi ET, Mertens L, Friedberg MK (2011) Assessment of myocardial deformation in children using Digital Imaging and Communications in Medicine (DICOM) data and vendor independent speckle tracking software. J Am Soc Echocardiogr 24:37–44
13. Hessel MH, Steendijk P, den Adel B, Schutte CI, van der Laarse A (2006) Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat. Am J Physiol Heart Circ Physiol 291:H2424–H2430
14. Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS, Kuebler WM (2011) An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol 44:725–738
15. van Heeswijk RB, De Blois J, Kania G, Gonzales C, Blyszczuk P, Stuber M, Eriksson U, Schwitter J (2013) Selective in vivo visualization of immune-cell infiltration in a mouse model of autoimmune myocarditis by fluorine-19 cardiac magnetic resonance. Circ Cardiovasc Imaging 6:277–284
16. Sun M, Opavsky MA, Stewart DJ, Rabinovitch M, Dawood F, Wen WH, Liu PP (2003) Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation 107:1046–1052
17. Shehata ML, Lossnitzer D, Skrok J, Boyce D, Lechtzin N, Mathai SC, Girgis RE, Osman N, Lima JA, Bluemke DA et al (2011) Myocardial delayed enhancement in pulmonary hypertension: pulmonary hemodynamics, right ventricular function, and remodeling. AJR Am J Roentgenol 196:87–94
18. Frey N, Olson EN (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65:45–79
19. Villarreal FJ, Dillmann WH (1992) Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen. Am J Physiol 262:H1861–H1866
20. Drake JI, Gomez-Arroyo J, Dumur CI, Kraskauskas D, Natarajan R, Bogaard HJ, Fawcett P, Voelkel NF (2013) Chronic carvedilol treatment partially reverses the right ventricular failure transcriptional profile in experimental pulmonary hypertension. Physiol Genomics 45:449–461
21. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K (1999) Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J Cell Physiol 181:153–159
22. Mu Y, Gudey SK, Landstrom M (2012) Non-Smad signaling pathways. Cell Tissue Res 347:11–20
23. Okada M, Kikuzuki R, Harada T, Hori Y, Yamawaki H, Hara Y (2008) Captopril attenuates matrix metalloproteinase-2 and -9 in monocrotaline-induced right ventricular hypertrophy in rats. J Pharmacol Sci 108:487–494
24. Stawowy P, Margeta C, Kallisch H, Seidah NG, Chretien M, Fleck E, Graf K (2004) Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Cardiovasc Res 63:87–97
25. Zhang YJ, Xiang MX, San J, Cheng G, Wang SS (2006) Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload. J Zhejiang Univ Sci B 7:245–250
26. Dewachter C, Dewachter L, Rondelet B, Fesler P, Brimioulle S, Kerbaul F, Naeije R (2010) Activation of apoptotic pathways in experimental acute afterload-induced right ventricular failure. Crit Care Med 38:1405–1413
27. Periasamy M, Bhupathy P, Babu GJ (2008) Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology. Cardiovasc Res 77:265–273
28. Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-beta family signaling. Nature 425:577–584