Pathophysiology of Infantile Pulmonary Arterial Hypertension Induced by Monocrotaline

Pediatric Cardiology

Volumn 36, Issue 5, 2015, Pages 1000-1013

  Dias Neto, Marina ^a   Luísa Neves, Ana ^a   Pinho, Sónia ^a   Gonçalves, Nádia ^a   Mendes, Maria ^a   Eloy, Catarina ^b   Lopes, José M ^b   Gonçalves, Daniel ^a   Ferreira Pinto, Manuel ^a   Leite Moreira, Adelino F ^a   Henriques Coelho, Tiago ^a  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cardiac hypertrophy; Endothelin 1; Islet1; Pediatric; Pulmonary arterial hypertension; Right ventricle

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; ENDOTHELIN 1; MESSENGER RNA; MONOCROTALINE; PYRROLIZIDINE ALKALOID; TRANSCRIPTION FACTOR;

ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; FEMALE; HEART; HEART MUSCLE CELL; HEART RIGHT VENTRICLE HYPERTROPHY; HEMODYNAMICS; LUNG; MALE; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; RAT; TIME; VASCULARIZATION; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; COLLAGEN TYPE I; COLLAGEN TYPE III; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; FEMALE; HEART; HEMODYNAMICS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; LUNG; MALE; MONOCROTALINE; MYOCYTES, CARDIAC; NATRIURETIC PEPTIDE, BRAIN; PYRROLIZIDINE ALKALOIDS; RATS; RATS, WISTAR; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 84939946817     PISSN: 01720643     EISSN: 14321971     Source Type: Journal    
DOI: 10.1007/s00246-015-1111-y     Document Type: Article

References (34)

1. Adachi S, Ito H, Ohta Y, Tanaka M, Ishiyama S, Nagata M, Toyozaki T, Hirata Y, Marumo F, Hiroe M (1995) Distribution of mRNAs for natriuretic peptides in RV hypertrophy after pulmonary arterial banding. Am J Physiol 268:H162–H169
2. Akazawa H, Komuro I (2003) Roles of cardiac transcription factors in cardiac hypertrophy. Circ Res 92:1079–1088
3. Bourdillon PD, Oakley CM (1976) Regression of primary pulmonary hypertension. Br Heart J 38:264–270
4. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S (2003) Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 5:877–889
5. Campian ME, Verberne HJ, Hardziyenka M, de Bruin K, Selwaness M, van den Hoff MJ, Ruijter JM, van Eck-Smit BL, de Bakker JM, Tan HL (2009) Serial noninvasive assessment of apoptosis during right ventricular disease progression in rats. J Nucl Med 50:1371–1377
6. Correia-Pinto J, Henriques-Coelho T, Roncon-Albuquerque R Jr, Lourenco AP, Melo-Rocha G, Vasques-Novoa F, Gillebert TC, Leite-Moreira AF (2009) Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension. Basic Res Cardiol 104:535–545
7. Epstein JA, Parmacek MS (2005) Recent advances in cardiac development with therapeutic implications for adult cardiovascular disease. Circulation 112:592–597
8. Falcao-Pires I, Goncalves N, Henriques-Coelho T, Moreira-Goncalves D, Roncon-Albuquerque R Jr, Leite-Moreira AF (2009) Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 296:H2007–H2014
9. Frank L, Bucher JR, Roberts RJ (1978) Oxygen toxicity in neonatal and adult animals of various species. J Appl Physiol 45:699–704
10. Fujii A, Rabinovitch M, Matthews EC (1981) A case of spontaneous resolution of idiopathic pulmonary hypertension. Br Heart J 46:574–577
11. Garciarena CD, Pinilla OA, Nolly MB, Laguens RP, Escudero EM, Cingolani HE, Ennis IL (2009) Endurance training in the spontaneously hypertensive rat: conversion of pathological into physiological cardiac hypertrophy. Hypertension 53:708–714
12. Henriques-Coelho T, Correia-Pinto J, Roncon-Albuquerque R Jr, Baptista MJ, Lourenco AP, Oliveira SM, Brandao-Nogueira A, Teles A, Fortunato JM, Leite-Moreira AF (2004) Endogenous production of ghrelin and beneficial effects of its exogenous administration in monocrotaline-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 287:H2885–H2890
13. Ismat FA, Zhang M, Kook H, Huang B, Zhou R, Ferrari VA, Epstein JA, Patel VV (2005) Homeobox protein Hop functions in the adult cardiac conduction system. Circ Res 96:898–903
14. Jasmin JF, Lucas M, Cernacek P, Dupuis J (2001) Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension. Circulation 103:314–318
15. Junqueira LC, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11:447–455
16. Kook H, Lepore JJ, Gitler AD, Lu MM, Yung WWM, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA (2003) Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. J Clin Invest 112:863–871
17. Lalich JJ, Merkow L (1961) Pulmonary arteritis produced in rat by feeding Crotalaria spectabilis. Lab Invest 10:744–750
18. Laugwitz KL, Moretti A, Lam J, Gruber P, Chen Y, Woodard S, Lin LZ, Cai CL, Lu MM, Reth M, Platoshyn O, Yuan JX, Evans S, Chien KR (2005) Postnatal isl1 + cardioblasts enter fully differentiated cardiomyocyte lineages. Nature 433:647–653
19. Loscalzo J (1992) Endothelial dysfunction in pulmonary hypertension. N Engl J Med 327:117–119
20. Mattocks AR (1968) Toxicity of pyrrolizidine alkaloids. Nature 217:723–728
21. Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K (1993) Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res 73:887–897
22. Piepoli MF, Capucci A (2009) Cardiac regeneration by progenitor cells: what is it known as and what is it still to be known as? Cardiovasc Hematol Agents Med Chem 7:127–136
23. Rabinovitch M, Gamble WJ, Miettinen OS, Reid L (1981) Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am J Physiol 240:H62–H72
24. Rabinovitch M, Keane JF, Norwood WI, Castaneda AR, Reid L (1984) Vascular structure in lung tissue obtained at biopsy correlated with pulmonary hemodynamic findings after repair of congenital heart defects. Circulation 69:655–667
25. Reffelmann T, Kloner RA (2009) Intracoronary blood- or bone marrow-derived cell transplantation in patients with ischemic heart disease. Regen Med 4:709–719
26. Reid MJ, Lame MW, Morin D, Wilson DW, Segall HJ (1998) Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes. J Biochem Mol Toxicol 12:157–166
27. Rosenzweig EB, Barst RJ (2008) Pulmonary arterial hypertension in children: a medical update. Curr Opin Pediatr 20:288–293
28. Rosenzweig EB, Widlitz AC, Barst RJ (2004) Pulmonary arterial hypertension in children. Pediatr Pulmonol 38:2–22
29. Stamm C, Choi YH, Nasseri B, Hetzer R (2009) A heart full of stem cells: the spectrum of myocardial progenitor cells in the postnatal heart. Ther Adv Cardiovasc Dis 3:215–229
30. Su X, Brower G, Janicki JS, Chen YF, Oparil S, Dell’Italia LJ (1999) Differential expression of natriuretic peptides and their receptors in volume overload cardiac hypertrophy in the rat. J Mol Cell Cardiol 31:1927–1936
31. Tatebe S, Miyamura H, Sugawara M, Watanabe H, Eguchi S (1996) Induction of right ventricular hypertrophy in neonatal guinea pigs by monocrotaline. Jpn Circ J 60:604–608
32. Todd L, Mullen M, Olley PM, Rabinovitch M (1985) Pulmonary toxicity of monocrotaline differs at critical periods of lung development. Pediatr Res 19:731–737
33. Ueno M, Miyauchi T, Sakai S, Kobayashi T, Goto K, Yamaguchi I (1999) Effects of physiological or pathological pressure load in vivo on myocardial expression of ET-1 and receptors. Am J Physiol 277:R1321–R1330
34. Zuo XR, Wang Q, Cao Q, Yu YZ, Wang H, Bi LQ, Xie WP, Wang H (2012) Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension. PLoS One 7:e44485