Supplemental Carvacrol Can Reduce the Severity of Inflammation by Influencing the Production of Mediators of Inflammation

Inflammation

Volumn 38, Issue 3, 2015, Pages 1020-1027

  Kara, Mehmet ^a   Uslu, Sema ^a   Demirci, Fatih ^b   Temel, Halide Edip ^b   Baydemir, Canan ^c  

^a ESKISEHIR OSMANGAZI UNIVERSITY   (Turkey)

^b ANADOLU UNIVERSITY   (Turkey)

^c KOCAELI UNIVERSITY   (Turkey)

Author keywords

arginase; carvacrol; interleukin 6; nitric oxide; sepsis; tumor necrosis factor alpha

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARGINASE; AUTACOID; BIOLOGICAL MARKER; CARVACROL; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MALONALDEHYDE; NITRIC OXIDE; TERPENE; TUMOR NECROSIS FACTOR;

ANIMAL; BLOOD; FEMALE; IMMUNOLOGY; INFLAMMATION; METABOLISM; RAT; SEPSIS; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; ARGINASE; BIOMARKERS; FEMALE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALONDIALDEHYDE; MONOTERPENES; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84939934480     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0066-0     Document Type: Article

References (47)

1. Rittirsch, D., M.A. Flierl, and P.A. Ward. 2008. Harmful molecular mechanisms in sepsis. Nature Reviews Immunology 8(10): 776–787.
2. Ward, P.A. 2012. New approaches to the study of sepsis. EMBO Molecular Medicine 4(12): 1234–1243.
3. Olinga, P., M.T. Merema, M.H. de Jager, F. Derks, B.N. Melgert, H. Moshage, et al. 2001. Rat liver slices as a tool to study LPS-induced inflammatory response in the liver. Journal of Hepatology 35(2): 187–194.
4. Parratt, J.R. 1998. Nitric oxide in sepsis and endotoxaemia. The Journal of Antimicrobial Chemotherapy 41(Suppl A): 31–39.
5. Rosengarten, B., S. Wolff, S. Klatt, and R.T. Schermuly. 2009. Effects of inducible nitric oxide synthase inhibition or norepinephrine on the neurovascular coupling in an endotoxic rat shock model. Critical Care 13(4): R139.
6. Popovic, P.J., H.J. Zeh 3rd, and J.B. Ochoa. 2007. Arginine and immunity. The Journal of Nutrition 137(6 Suppl 2): 1681S–1686S.
7. Bronte, V., and P. Zanovello. 2005. Regulation of immune responses by L-arginine metabolism. Nature Reviews Immunology 5(8): 641–654.
8. Bayramoglu G, Senturk H, Bayramoglu A, Uyanoglu M, Colak S, Ozmen A, et al. Carvacrol partially reverses symptoms of diabetes in STZ-induced diabetic rats. Cytotechnology. 2013.
9. Lei, J., M. Leser, and E. Enan. 2010. Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans. Biochemical Pharmacology 79(7): 1062–1071.
10. Koparal, A.T., and M. Zeytinoglu. 2003. Effects of carvacrol on a human non-small cell lung cancer (NSCLC) cell line, A549. Cytotechnology 43(1–3): 149–154.
11. Baser, K.H.C. 2008. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Current Pharmaceutical Design 14(29): 3106–3119.
12. Jayakumar, S., A. Madankumar, S. Asokkumar, S. Raghunandhakumar, K. Gokula dhas, S. Kamaraj, et al. 2012. Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Molecular and Cellular Biochemistry 360(1–2): 51–60.
13. Aristatile, B., K.S. Al-Numair, C. Veeramani, and K.V. Pugalendi. 2009. Effect of carvacrol on hepatic marker enzymes and antioxidant status in d-galactosamine-induced hepatotoxicity in rats. Fundamental & Clinical Pharmacology 23(6): 757–765.
14. Recknagel, P., F.A. Gonnert, E. Halilbasic, M. Gajda, N. Jbeily, A. Lupp, et al. 2013. Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver International 33(2): 283–293.
15. Williamson K, Hensley K, Floyd R (2003) Fluorometric and colorimetric assessment of thiobarbituric acid-reactive lipid aldehydes in biological matrices. In: Hensley K, Floyd R (eds) Methods in biological oxidative stress. Methods in pharmacology and toxicology: Humana Press; 2003. p. 57–65.
16. Cortas, N.K., and N.W. Wakid. 1990. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clinical Chemistry 36(8 Pt 1): 1440–1443.
17. Miranda, K.M., M.G. Espey, and D.A. Wink. 2001. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5(1): 62–71.
18. Corraliza, I.M., M.L. Campo, G. Soler, and M. Modolell. 1994. Determination of arginase activity in macrophages: a micromethod. Journal of Immunological Methods 174(1–2): 231–235.
19. Munder, M., K. Eichmann, and M. Modolell. 1998. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. Journal of Immunology 160(11): 5347–5354.
20. Kavoosi, G., and J.A. Teixeira da Silva. 2012. Inhibitory effects of Zataria multiflora essential oil and its main components on nitric oxide and hydrogen peroxide production in glucose-stimulated human monocyte. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 50(9): 3079–3085.
21. Guimarães, A.G., M.A. Xavier, M.T. de Santana, E.A. Camargo, C.A. Santos, F.A. Brito, et al. 2012. Carvacrol attenuates mechanical hypernociception and inflammatory response. Naunyn-Schmiedeberg's Archives of Pharmacology 385(3): 253–263.
22. Lima, M.S., L.J. Quintans-Júnior, W.A. de Santana, C. Martins Kaneto, M.B. Pereira Soares, and C.F. Villarreal. 2013. Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10. European Journal of Pharmacology 699(1–3): 112–117.
23. Fehrenbacher JC, Vasko MR, Duarte DB (2012) Models of inflammation: Carrageenan- or complete Freund’s Adjuvant (CFA)-induced edema and hypersensitivity in the rat. Current Protocols in Pharmacology. 2012; Chapter 5:Unit5.4.
24. Essani, N.A., M.A. Fisher, and H. Jaeschke. 1997. Inhibition of NF-kappa B activation by dimethyl sulfoxide correlates with suppression of TNF-alpha formation, reduced ICAM-1 gene transcription, and protection against endotoxin-induced liver injury. Shock 7(2): 90–96.
25. Chang, C.K., M.V. Albarillo, and W. Schumer. 2001. Therapeutic effect of dimethyl sulfoxide on ICAM-1 gene expression and activation of NF-kappaB and AP-1 in septic rats. The Journal of Surgical Research 95(2): 181–187.
26. Chang, C.K., S. Llanes, and W. Schumer. 1999. Inhibitory effect of dimethyl sulfoxide on nuclear factor-kappa B activation and intercellular adhesion molecule 1 gene expression in septic rats. The Journal of Surgical Research 82(2): 294–299.
27. Çakmak A AS. Variation of the analgesic effect of carvacrol: influence of solvents. 6th European Congress of Pharmacology 2012:P318.
28. Kaplanski, G., V. Marin, F. Montero-Julian, A. Mantovani, and C. Farnarier. 2003. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends in Immunology 24(1): 25–29.
29. Buras, J.A., B. Holzmann, and M. Sitkovsky. 2005. Animal models of sepsis: setting the stage. Nature Reviews Drug Discovery 4(10): 854–865.
30. JONES, S.A., S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G.M. FULLER. 2001. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. The FASEB Journal 15(1): 43–58.
31. Korhonen, R., A. Lahti, H. Kankaanranta, and E. Moilanen. 2005. Nitric oxide production and signaling in inflammation. Current Drug Targets. Inflammation and Allergy 4(4): 471–479.
32. Sharma, J.N., A. Al-Omran, and S.S. Parvathy. 2007. Role of nitric oxide in inflammatory diseases. Inflammopharmacology 15(6): 252–259.
33. Hotta, M., R. Nakata, M. Katsukawa, K. Hori, S. Takahashi, and H. Inoue. 2010. Carvacrol, a component of thyme oil, activates PPARalpha and gamma and suppresses COX-2 expression. Journal of Lipid Research 51(1): 132–139.
34. Feng, X., and A. Jia. 2014. Protective effect of carvacrol on acute lung injury induced by lipopolysaccharide in mice. Inflammation 37(4): 1091–1101.
35. Moraes, L.A., L. Piqueras, and D. Bishop-Bailey. 2006. Peroxisome proliferator-activated receptors and inflammation. Pharmacology and Therapeutics 110(3): 371–385.
36. Koksal, G.M., C. Sayilgan, S. Aydin, H. Oz, and H. Uzun. 2004. Correlation of plasma and tissue oxidative stresses in intra-abdominal sepsis. Journal of Surgical Research 122(2): 180–183.
37. Lorente, L., M.M. Martin, P. Abreu-Gonzalez, A. Dominguez-Rodriguez, L. Labarta, C. Diaz, et al. 2013. Prognostic value of malondialdehyde serum levels in severe sepsis: a multicenter study. PloS One 8(1): e53741.
38. Aydın E, Türkez H, Keleş MS. The effect of carvacrol on healthy neurons and N2a cancer cells: Some biochemical, anticancerogenicity and genotoxicity studies. Cytotechnology. 2013.
39. Carraway, M.S., C.A. Piantadosi, C.P. Jenkinson, and Y.C. Huang. 1998. Differential expression of arginase and iNOS in the lung in sepsis. Experimental Lung Research 24(3): 253–268.
40. Zhang, W., B. Baban, M. Rojas, S. Tofigh, S.K. Virmani, C. Patel, et al. 2009. Arginase activity mediates retinal inflammation in endotoxin-induced uveitis. The American Journal of Pathology 175(2): 891–902.
41. Lee, E.J., Y.R. Lee, H.K. Joo, E.J. Cho, S. Choi, K.C. Sohn, et al. 2013. Arginase II inhibited lipopolysaccharide-induced cell death by regulation of iNOS and Bcl-2 family proteins in macrophages. Molecules and Cells 35(5): 396–401.
42. Munder, M., H. Schneider, C. Luckner, T. Giese, C.D. Langhans, J.M. Fuentes, et al. 2006. Suppression of T-cell functions by human granulocyte arginase. Blood 108(5): 1627–1634.
43. Rodriguez, P.C., D.G. Quiceno, and A.C. Ochoa. 2007. L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood 109(4): 1568–1573.
44. Salimuddin, A. Nagasaki, T. Gotoh, H. Isobe, and M. Mori. 1999. Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide. The American Journal of Physiology 277(1 Pt 1): E110–E117.
45. Louis, C.A., J.S. Reichner, W.L. Henry Jr., B. Mastrofrancesco, T. Gotoh, M. Mori, et al. 1998. Distinct arginase isoforms expressed in primary and transformed macrophages: regulation by oxygen tension. The American Journal of Physiology 274(3 Pt 2): R775–R782.
46. Schilling T, Miralles F, Eder C. TRPM7 channels regulate proliferation and polarisation of macrophages. Journal of Cell Science. 2014.
47. Parnas, M., M. Peters, D. Dadon, S. Lev, I. Vertkin, I. Slutsky, et al. 2009. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45(3): 300–309.