Oleic acid-induced hepatic steatosis is coupled with downregulation of aquaporin 3 and upregulation of aquaporin 9 via activation of p38 signaling

Hormone and Metabolic Research

Volumn 47, Issue 4, 2015, Pages 259-264

  Gu, L Y ^a   Qiu, L W ^a   Chen, X F ^a   Lu L ^a   Mei, Z C ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

channel proteins; lipid accumulation; nonalcoholic fatty liver disease; signaling pathway

Indexed keywords

AQP9 PROTEIN, HUMAN; AQUAPORIN; AQUAPORIN 3; MESSENGER RNA; OLEIC ACID; TRIACYLGLYCEROL;

CHEMICALLY INDUCED; DOWN REGULATION; DRUG EFFECTS; FATTY LIVER; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; HUMAN; NONALCOHOLIC FATTY LIVER; SIGNAL TRANSDUCTION; UPREGULATION;

AQUAPORIN 3; AQUAPORINS; DOWN-REGULATION; FATTY LIVER; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; NON-ALCOHOLIC FATTY LIVER DISEASE; OLEIC ACID; RNA, MESSENGER; TRIGLYCERIDES; UP-REGULATION;

EID: 84939896320     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1384569     Document Type: Article

References (30)

1. Cheung O., Sanyal A. J. Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. Semin Liver Dis: 2008; 28 351 359
2. Tiniakos D. G., Vos M. B., Brunt E. M. Nonalcoholic fatty liver disease: pathology and pathogenesis. Annu Rev Pathol: 2010; 5 145 171
3. Gao D., Nong S., Huang X., Lu Y., Zhao H., Lin Y., Man Y., Wang S., Yang J., Li J. The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways. J Biol Chem: 2010; 285 29965 29973
4. Verkman A. S. Aquaporins in clinical medicine. Annu Rev Med: 2012; 63 303 316
5. Ishibashi K., Kondo S., Hara S., Morishita Y. The evolutionary aspects of aquaporin family. Am J Physiol Regul Integr Comp Physiol: 2011; 300 R566 R576
6. Buffoli B. Aquaporin biology and nervous system. Curr Neuropharmacol: 2010; 8 97 104
7. Ryu H. M., Oh E. J., Park S. H., Kim C. D., Choi J. Y., Cho J. H., Kim I. S., Kwon T. H., Chung H. Y., Yoo M., Kim Y. L. Aquaporin 3 expression is up-regulated by TGF-β1 in rat peritoneal mesothelial cells and plays a role in wound healing. Am J Pathol: 2012; 181 2047 2057
8. Rodríguez A., Catalán V., Gómez-Ambrosi J., García-Navarro S., Rotellar F., Valentí V., Silva C., Gil M. J., Salvador J., Burrell M. A., Calamita G., Malagón M. M., Frühbeck G. Insulin- and leptin-mediated control of aquaglyceroporins in human adipocytes and hepatocytes is mediated via the PI3K/Akt/mTOR signaling cascade. J Clin Endocrinol Metab: 2011; 96 E586 E597
9. Rojek A. M., Skowronski M. T., Füchtbauer E. M., Füchtbauer A. C., Fenton R. A., Agre P., Frokiaer J., Nielsen S. Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice. Proc Natl Acad Sci USA: 2007; 104 3609 3614
10. Cai C., Wang C., Ji W., Liu B., Kang Y., Hu Z., Jiang Z. Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats. Int Immunopharmacol: 2013; 15 550 556
11. Wang C., Lv Z. L., Kang Y. J., Xiang T. X., Wang P. L., Jiang Z. Aquaporin-9 downregulation prevents steatosis in oleic acid-induced non-alcoholic fatty liver disease cell models. Int J Mol Med: 2013; 32 1159 1165
12. van der Vusse G. J. Albumin as fatty acid transporter. Drug Metab Pharmacokinet: 2009; 24 300 307
13. Pagliassotti M. J. Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annu Rev Nutr: 2012; 32 17 33
14. Nehra V., Angulo P., Buchman A. L., Lindor K. D. Nutritional and metabolic considerations in the etiology of nonalcoholic steatohepatitis. Dig Dis Sci: 2001; 46 2347 2352
15. Soardo G., Donnini D., Domenis L., Catena C., De Silvestri D., Cappello D., Dibenedetto A., Carnelutti A., Bonasia V., Pagano C., Sechi L. A. Oxidative stress is activated by free fatty acids in cultured human hepatocytes. Metab Syndr Relat Disord: 2011; 9 397 401
16. Lian Z., Li Y., Gao J., Qu K., Li J., Hao L., Wu S., Zhu H. A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells. Lipids Health Dis: 2011; 10 67
17. Vidyashankar S., Sandeep Varma R., Patki P. S. Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol In Vitro: 2013; 27 945 953
18. Tilg H. Adipocytokines in nonalcoholic fatty liver disease: key players regulating steatosis, inflammation and fibrosis. Curr Pharm Des: 2010; 16 1893 1895
19. Vidyashankar S., Sandeep Varma R., Patki P. S. Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol In Vitro: 2013; 27 945 953
20. Vidyashankar S., Sharath Kumar L. M., Barooah V., Sandeep Varma R., Nandakumar K. S., Patki P. S. Liv.52 up-regulates cellular antioxidants and increase glucose uptake to circumvent oleic acid induced hepatic steatosis in HepG2 cells. Phytomedicine: 2012; 19 1156 1165
21. Song C. Y., Shi J., Zeng X., Zhang Y., Xie W. F., Chen Y. X. Sophocarpine alleviates hepatocyte steatosis through activating AMPK signaling pathway. Toxicol In Vitro: 2013; 27 1065 1071
22. Wu H. T., Chen W., Cheng K. C., Ku P. M., Yeh C. H., Cheng J. T. Oleic acid activates peroxisome proliferator-activated receptor δ to compensate insulin resistance in steatotic cells. J Nutr Biochem: 2012; 23 1264 1270
23. Lee D. H., Park D. B., Lee Y. K., An C. S., Oh Y. S., Kang J. S., Kang S. H., Chung M. Y. The effects of thiazolidinedione treatment on the regulations of aquaglyceroporins and glycerol kinase in OLETF rats. Metabolism: 2005; 54 1282 1289
24. Cai C., Wang C., Ji W., Liu B., Kang Y., Hu Z., Jiang Z. Knockdown of hepatic aquaglyceroporin-9 alleviates high fat diet-induced non-alcoholic fatty liver disease in rats. Int Immunopharmacol: 2013; 15 550 556
25. Rodríguez A., Catalán V., Gómez-Ambrosi J., Frühbeck G. Aquaglyceroporins serve as metabolic gateways in adiposity and insulin resistance control. Cell Cycle: 2011; 10 1548 1556
26. Calamita G., Gena P., Ferri D., Rosito A., Rojek A., Nielsen S., Marinelli R. A., Frühbeck G., Svelto M. Biophysical assessment of aquaporin-9 as principal facilitative pathway in mouse liver import of glucogenetic glycerol. Biol Cell: 2012; 104 342 351
27. Hibuse T., Maeda N., Funahashi T., Yamamoto K., Nagasawa A., Mizunoya W., Kishida K., Inoue K., Kuriyama H., Nakamura T., Fushiki T., Kihara S., Shimomura I. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc Natl Acad Sci USA: 2005; 102 10993 10998
28. Sinha-Hikim I., Sinha-Hikim A. P., Shen R., Kim H. J., French S. W., Vaziri N. D., Crum A. C., Rajavashisth T. B., Norris K. C. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol: 2011; 91 419 428
29. Aghazadeh S., Yazdanparast R. Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clin Nutr: 2010; 29 381 385
30. Patsouris D., Mandard S., Voshol P. J., Escher P., Tan N. S., Havekes L. M., Koenig W., März W., Tafuri S., Wahli W., Müller M., Kersten S. PPARalpha governs glycerol metabolism. J Clin Invest: 2004; 114 94 103