Synergistic anticancer effects of lectin and doxorubicin in breast cancer cells

Molecular and Cellular Biochemistry

Volumn 394, Issue 1-2, 2014, Pages 225-235

  Hong, Chang Eui ^a   Park, Ae Kyung ^b   Lyu, Su Yun ^b  

^a Chonnam National University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

Apoptosis; Breast cancer; Doxorubicin; Drug combination; Mistletoe lectin

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; APOPTOSIS REGULATORY PROTEIN; DOXORUBICIN; PLANT LECTIN;

APOPTOSIS; BREAST TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; FEMALE; HUMAN; ISOLATION AND PURIFICATION; MCF 7 CELL LINE; METABOLISM; PATHOLOGY; S PHASE CELL CYCLE CHECKPOINT; VISCUM ALBUM;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SYNERGISM; FEMALE; HUMANS; MCF-7 CELLS; PLANT LECTINS; S PHASE CELL CYCLE CHECKPOINTS; VISCUM ALBUM;

EID: 84939888480     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-014-2099-y     Document Type: Article

References (27)

1. Büssing A, Suzart K, Bergmann J, Pfüller U, Schweizer K (1996) Induction of apoptosis in human lymphocytes treated with Viscum album L. is mediated by the mistletoe lectins. Cancer Lett 99:59–72
2. Hajto T, Hostanska K, Frei K, Rordorf C, Gabius HJ (1990) Increased secretion of tumor necrosis factor α, interleukin 1, and interleukin 6 by human mononuclear cells exposed to β-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50:3322–3326
3. Schultze JL, Stettin A, Berg PA (1991) Demonstration of specifically sensitized lymphocytes in patients treated with an aqueous mistletoe extract (Viscum album L.). Klinische Wochenschrift 69:397–403
4. Urech K, Scher JM, Hostanska K, Becker H (2005) Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L. J Pharm Pharmacol 57:101–109
5. Park WB, Lyu SY, Kim JH, Choi SH, Chung HK, Ahn SH, Hong SY, Yoon TJ, Choi MJ (2001) Inhibition of tumor growth and metastasis by Korean mistletoe lectin is associated with apoptosis and antiangiogenesis. Cancer Biother Radiopharm 16:439–447
6. Franz H, Ziska P, Kindt A (1981) Isolation and properties of three lectins from mistletoe (Viscum album L.). Biochem J 195:481–484
7. Peumans WJ, Verhaert P, Pfüller U, Van Damme EJ (1996) Isolation and partial characterization of a small chitin-binding lectin from mistletoe (Viscum album). FEBS Lett 396:261–265
8. Lyu SY, Park SM, Choung BY, Park WB (2000) Comparative study of Korean (Viscum album var. coloratum) and European mistletoes (Viscum album). Arch Pharm Res 23:592–598
9. Yoon TJ, Yoo YC, Kang TB, Shimazaki K, Song SK, Lee KH, Kim SH, Park CH, Azuma I, Kim JB (1999) Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells. Cancer Lett 136:33–40
10. Choi SH, Lyu SY, Park WB (2004) Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of Akt. Arch Pharm Res 27:68–76
11. Kasahara K, Fujiwara Y, Sugimoto Y, Nishio K, Tamura T, Matsuda T, Saijo N (1992) Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines. J Natl Cancer Inst 84:113–118
12. Hortobagyi GN (1997) Chemotherapy of breast cancer: a historical perspective. Semin Oncol S17:1–4
13. Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R (2004) Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat 85:1–12
14. Park WB, Han SK, Lee MH, Han KH (1997) Isolation and characterizaton of lectins from stem and leaves of Korean mistletoe (Viscum album L. var. coloratum) by affinity chromatography. Arch Pharm Res 20:306–312
15. Park WB, Ju YJ, Han SK (1998) Isolation and characterization of beta-galactoside specific lectin from Korean mistletoe (Viscum album var. coloratum) with lactose-BSA-sepharose 4B and changes of lectin conformation. Arch Pharm Res 21:429–435
16. Chou T, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27–55
17. Lyu SY, Choi SH, Park WB (2002) Korean mistletoe lectin-induced apoptosis in hepatocarcinoma cells is associated with inhibition of telomerase via mitochondrial controlled pathway independent of p53. Arch Pharm Res 25:93–101
18. Tyagi AK, Singh RP, Agarwal C, Chan DCF, Agarwal R (2002) Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest and apoptosis. Clin Cancer Res 8:3512–3519
19. Hortobagyi GN (2001) Progress in systemic chemotherapy of primary breast cancer: an overview. J Natl Cancer Inst Monogr 2001:72–79
20. Sarath VJ, So CS, Won YD, Gollapudi S (2007) Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells. Anticancer Res 27:3891–3898
21. Riggins RB, Bouton AH, Liu MC, Clarke R (2005) Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer. Vitam Horm 71:201–237
22. Quintier L, Fantin M, Vizler C (2007) Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs. Adv Exp Med Biol 593:95–100
23. Rabbani A, Finn RM, Ausió J (2005) The anthracycline antibiotics: antitumor drugs that alter chromatin structure. BioEssays 27:50–56
24. Belka C, Jendrossek V, Pruschy M, Vink S, Verheij M, Budach W (2004) Apoptosis-modulating agents in combination with radiotherapy-current status and outlook. Int J Radiat Oncol Biol Phys 58:542–554
25. Bouillet P, Strasser A (2002) BH3-only proteins—evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci 115(Pt 8):1567–1574
26. Murphy KM, Ranganathan V, Farnsworth ML, Kavallaris M, Lock RB (2000) Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 7:102–111
27. Mirza S, Sharma G, Pandya P, Ralhan R (2010) Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents. Mol Cell Biochem 342:101–109