Metabolites identification of bioactive licorice compounds in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 115, Issue , 2015, Pages 515-522

  Wang, Qi ^a   Qian, Yi ^a   Wang, Qing ^a   Yang, Yan fang ^a   Ji, Shuai ^a   Song, Wei ^a   Qiao, Xue ^a   Guo, De an ^a   Liang, Hong ^a   Ye, Min ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Flavonoid; Glycyrrhiza uralensis; Liquid chromatography coupled with mass spectrometry; Metabolites identification; Saponin

Indexed keywords

3 METHOXY 9 HYDROXY PTEROCARPAN; DRUG METABOLITE; GLUCURONIC ACID; GLYCYRRHIZA URALENSIS EXTRACT; GLYCYRRHIZIC ACID; ISOGLYCYCOUMARIN; LICOFLAVONOL; LICOISOFLAVANONE; LICORICIDIN; PHENOL DERIVATIVE; SEMILICOISOFLAVONE B; UNCLASSIFIED DRUG; GLUCURONIDE; PLANT EXTRACT; SULFATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG FECES LEVEL; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG SULFATION; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; GLYCYRRHIZA URALENSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; BIOTRANSFORMATION; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; FECES; GLYCYRRHIZA; HYDROLYSIS; HYDROXYLATION; MEDICINAL PLANT; ORAL DRUG ADMINISTRATION; PHYTOTHERAPY; SPRAGUE DAWLEY RAT; URINE;

ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; GLUCURONIDES; GLYCYRRHIZA; HYDROLYSIS; HYDROXYLATION; MALE; MOLECULAR STRUCTURE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFATES;

EID: 84939806914     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2015.08.013     Document Type: Article

References (13)

1. Zhang Q.Y., Ye M. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). J. Chromatogr. A 2009, 1216:1954-1969.
2. Wang Q., Qiao X., Qian Y., Liu C.F., Yang Y.F., Ji S., Li J., Guo D.A., Ye M. Metabolites identification of glycyrin and glycyrol, bioactive coumarins from licorice. J. Chromatogr. B 2015, 983-984:39-46.
3. Qiao X., Liu C.F., Ji S., Lin X.H., Guo D.A., Ye M. Simultaneous determination of five minor coumarins and flavonoids in Glycyrrhiza uralensis by solid phase extraction and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. Planta Med. 2014, 80:237-242.
4. Song W., Si L.L., Ji S., Wang H., Fang X.M., Yu L.Y., Li R.Y., Liang L.N., Zhou D.M., Ye M. Uralsaponins M-Y, antiviral triterpenoid saponins from the root of Glycyrrhiza uralensis. J. Nat. Prod. 2014, 77:1632-1643.
5. Xiang C., Qiao X., Wang Q., Li R., Miao W.J., Guo D.A., Ye M. From single compounds to herbal extract: a strategy to systematically characterize the metabolites of licorice in rats. Drug Metab. Dispos. 2011, 39:1597-1608.
6. Wang Q., Qiao X., Liu C.F., Ji S., Feng L.M., Qian Y., Guo D.A., Ye M. Metabolites identification of glycycoumarin, a major bioactive coumarin from licorice in rats. J. Pharm. Biomed. Anal. 2014, 98:287-295.
7. Kitagawa I., Zhou J.L., Sakagami M., Taniyama T., Yoshikawa M. Licorice-saponins A3, B2, C2, D3, and E2, five new oleanene-type triterpene oligoglycosides from Chinese Glycyrrhizae Radix. Chem. Pharm. Bull. 1988, 36:3710-3713.
8. Gao K., Wei Y., Yang J. X.H. Duan CYP3A1/2 and 2C9/10 in rat liver microsomes mediate 22α- and 24-hydroxylation of 18α-glycyrrhetinic acid. Chin. Clin. Pharmacol. Ther. 2007, 12:1255-1260.
9. Salomatina O.V., Markov A.V., Logashenko E.B., Korchagina D.V., Zenkova M.A., Salakhutdinov N.F., Vlassov V.V., Tolstikov G.A. Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells. Bioorg. Med. Chem. 2014, 22:585-593.
10. Simons R., Vincken J.P., Bakx E.J., Verbruggen M.A., Gruppen H. A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionization mass spectrometry in licorice root extracts. Rapid Commun. Mass Spectrom. 2009, 23:3083-3093.
11. Yang D.H., Ren X.L., Xu F., Ma X.Q., Liu G.X., Li C.H., Li C., Cai S.Q. Absorptive constituents and their metabolites in drug-containing urine samples form Wuzhishan miniature pigs orally administered with Buyang Huanwu decoction. J. Nat. Med. 2014, 68:11-21.
12. Manickavasagam L., Gupta S., Mishra S., Kumar A., Raghuvanshi A., Goel A., Singh D., Jain G.K. Determination of 3-hydroxy pterocarpan, a novel osteogenic compound in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetics study. Biomed. Chromatogr. 2011, 25:843-850.
13. Ploeger B., Mensinga T., Sips A., Seinen W., Meulenbelt J., DeJongh J. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. Drug Metab. Rev. 2001, 33:125-147.