Axonal transport in the rat optic nerve following short-term reduction in cerebrospinal fluid pressure or elevation in intraocular pressure

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 8, 2015, Pages 4257-4266

  Zhang, Zheng ^a   Liu, Danli ^b   Jonas, Jost B ^a,c   Wu, Shen ^a   Kwong, Jacky M K ^d   Zhang, Jingxue ^a   Liu, Qian ^a   Li, Lei ^a   Lu, Qingjun ^a   Yang, Diya ^a   Wang, Jinda ^a   Wang, Ningli ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d JULES STEIN EYE INSTITUTE   (United States)

Author keywords

Axonal transport; Cerebrospinal fluid pressure; Glaucoma; Intraocular pressure; Optic neuropathy

Indexed keywords

FLUOROGOLD; RHODAMINE; FLUORESCENT DYE; RHODAMINE ISOTHIOCYANATE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CELL DENSITY; CEREBROSPINAL FLUID PRESSURE; CONTROLLED STUDY; FLUORESCENCE IMAGING; GLAUCOMA; IMMUNOHISTOCHEMISTRY; INTRAOCULAR PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NERVE FIBER TRANSPORT; NONHUMAN; OPTIC NERVE; OPTIC NERVE DISEASE; PERFUSION PRESSURE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; RETINA GANGLION CELL; RETINA INJURY; RETROGRADE NERVE FIBER TRANSPORT; SUPERIOR COLLICULUS; ANIMAL; CYTOLOGY; DIAGNOSTIC USE; DISEASE MODEL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AXONAL TRANSPORT; CEREBROSPINAL FLUID PRESSURE; DISEASE MODELS, ANIMAL; FLUORESCENT DYES; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; OPTIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINES;

EID: 84939782940     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-16045     Document Type: Article

References (43)

1. Morgan WH, Yu DY, Cooper RL, Alder VA, Cringle SJ, Constable IJ. The influence of cerebrospinal fluid pressure on the lamina cribrosa tissue pressure gradient. Invest Ophthalmol Vis Sci. 1995;36:1163–1172
2. Jonas JB, Berenshtein E, Holbach L. Anatomic relationship between lamina cribrosa, intraocular space, and cerebrospinal fluid space. Invest Ophthalmol Vis Sci. 2003;44:5189–5195
3. Ren R, Jonas JB, Tian G, et al. Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology. 2010;117: 259–266
4. Morgan WH, Chauhan BC, Yu DY, Cringle SJ, Alder VA, House PH. Optic disc movement with variations in intraocular and cerebrospinal fluid pressure. Invest Ophthalmol Vis Sci. 2002; 43:3236–3242
5. Morgan WH, Yu DY, Balaratnasingam C. The role of cerebrospinal fluid pressure in glaucoma pathophysiology: the dark side of the optic disc. J Glaucoma. 2008;17:408–413
6. Berdahl JP, Allingham RR, Johnson DH. Cerebrospinal fluid pressure is decreased in primary open-angle glaucoma. Ophthalmology. 2008;115:763–768
7. Berdahl JP, Fautsch MP, Stinnett SS, Allingham RR. Intracranial pressure in primary open angle glaucoma, normal tension glaucoma, and ocular hypertension: a case-control study. Invest Ophthalmol Vis Sci. 2008;49:5412–5418
8. Ren R, Wang N, Zhang X, Cui T, Jonas JB. Trans-lamina cribrosa pressure difference correlated with neuroretinal rim area in glaucoma. Graefes Arch Clin Exp Ophthalmol. 2011;249: 1057–1063
9. Wang N, Xie X, Yang D, et al. Orbital cerebrospinal fluid space in glaucoma: the Beijing intracranial and intraocular pressure (iCOP) study. Ophthalmology. 2012;119:2065–2073. e2061
10. Yang D, Fu J, Hou R, et al. Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys. Invest Ophthalmol Vis Sci. 2014;55:3067–3073
11. Vrabec JP, Levin LA. The neurobiology of cell death in glaucoma. Eye (Lond). 2007;21(suppl 1):S11–S14
12. Johnson EC, Guo Y, Cepurna WO, Morrison JC. Neurotrophin roles in retinal ganglion cell survival: lessons from rat glaucoma models. Exp Eye Res. 2009;88:808–815
13. Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci. 2000;41:764–774
14. Martin KR, Quigley HA, Valenta D, Kielczewski J, Pease ME. Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma. Exp Eye Res. 2006;83:255–262
15. Minckler DS, Bunt AH, Johanson GW. Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the monkey. Invest Ophthalmol Vis Sci. 1977;16: 426–441
16. Johansson JO. Inhibition of retrograde axoplasmic transport in rat optic nerve by increased IOP in vitro. Invest Ophthalmol Vis Sci. 1983;24:1552–1558
17. Abbott CJ, Choe TE, Lusardi TA, Burgoyne CF, Wang L, Fortune B. Evaluation of retinal nerve fiber layer thickness and axonal transport 1 and 2 weeks after 8 hours of acute intraocular pressure elevation in rats. Invest Ophthalmol Vis Sci. 2014;55: 674–687
18. Balaratnasingam C, Morgan WH, Bass L, Matich G, Cringle SJ, Yu DY. Axonal transport and cytoskeletal changes in the laminar regions after elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2007;48:3632–3644
19. Balaratnasingam C, Morgan WH, Bass L, Cringle SJ, Yu DY. Time-dependent effects of elevated intraocular pressure on optic nerve head axonal transport and cytoskeleton proteins. Invest Ophthalmol Vis Sci. 2008;49:986–999
20. Balaratnasingam C, Cringle SJ, Fatehee N, Morgan WH, Yu DY. Comparison of fluctuating and sustained neural pressure perturbations on axonal transport processes in the optic nerve. Brain Res. 2011;1417:67–76
21. Anderson DR, Hendrickson A. Effect of intraocular pressure on rapid axoplasmic transport in monkey optic nerve. Invest Ophthalmol. 1974;13:771–783
22. Quigley H, Anderson DR. The dynamics and location of axonal transport blockade by acute intraocular pressure elevation in primate optic nerve. Invest Ophthalmol. 1976;15:606–616
23. Minckler DS, Bunt AH, Klock IB. Radioautographic and cytochemical ultrastructural studies of axoplasmic transport in the monkey optic nerve head. Invest Ophthalmol Vis Sci. 1978;17:33–50
24. Jonas JB, Nangia V, Wang N, et al. Trans-lamina cribrosa pressure difference and open-angle glaucoma. The central India eye and medical study. PLoS One. 2013;8:e82284
25. Jonas JB, Wang N, Wang YX, et al. Body height, estimated cerebrospinal fluid pressure and open-angle glaucoma. The Beijing Eye Study 2011. PLoS One. 2014;9:e86678
26. Jonas JB, Wang NL, Wang YX, et al. Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011. Acta Ophthalmol. 2014;93:e7–e13
27. Joos KM, Li C, Sappington RM. Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure. Invest Ophthalmol Vis Sci. 2010;51: 6431–6440
28. Fortune B, Yang H, Strouthidis NG, et al. The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness, and retardance. Invest Ophthalmol Vis Sci. 2009;50:4719–4726
29. Strouthidis NG, Fortune B, Yang H, Sigal IA, Burgoyne CF. Effect of acute intraocular pressure elevation on the monkey optic nerve head as detected by spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011;52: 9431–9437
30. Fortune B, Choe TE, Reynaud J, et al. Deformation of the rodent optic nerve head and peripapillary structures during acute intraocular pressure elevation. Invest Ophthalmol Vis Sci. 2011;52:6651–6661
31. Bui BV, Edmunds B, Cioffi GA, Fortune B. The gradient of retinal functional changes during acute intraocular pressure elevation. Invest Ophthalmol Vis Sci. 2005;46:202–213
32. He Z, Bui BV, Vingrys AJ. The rate of functional recovery from acute IOP elevation. Invest Ophthalmol Vis Sci. 2006;47: 4872–4880
33. Nagaraju M, Saleh M, Porciatti V. IOP-dependent retinal ganglion cell dysfunction in glaucomatous DBA/2J mice. Invest Ophthalmol Vis Sci. 2007;48:4573–4579
34. Bui BV, Batcha AH, Fletcher E, Wong VH, Fortune B. Relationship between the magnitude of intraocular pressure during an episode of acute elevation and retinal damage four weeks later in rats. PLoS One. 2013;8:e70513
35. Quigley HA, Anderson DR. Distribution of axonal transport blockade by acute intraocular pressure elevation in the primate optic nerve head. Invest Ophthalmol Vis Sci. 1977; 16:640–644
36. Johansson JO. Retrograde axoplasmic transport in rat optic nerve in vivo. What causes blockage at increased intraocular pressure? Exp Eye Res. 1986;43:653–660
37. Johansson JO. Inhibition and recovery of retrograde axoplasmic transport in rat optic nerve during and after elevated IOP in vivo. Exp Eye Res. 1988;46:223–227
38. Quigley HA, McKinnon SJ, Zack DJ, et al. Retrograde axonal transport of BDNF in retinal ganglion cells is blocked by acute IOP elevation in rats. Invest Ophthalmol Vis Sci. 2000;41: 3460–3466
39. Jiang J, Tyssebotn I. Measurement of cerebrospinal fluid pressure in conscious rats. Undersea Hyperb Med. 1997;24: 39–43
40. Lin JS, Liu JH. Circadian variations in intracranial pressure and translaminar pressure difference in Sprague-Dawley rats. Invest Ophthalmol Vis Sci. 2010;51:5739–5743
41. Killer HE, Laeng HR, Flammer J, Groscurth P. Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations. Br J Ophthalmol. 2003;87:777–781
42. Pache M, Meyer P. Morphological changes of the retrobulbar optic nerve and its meningeal sheaths in glaucoma. Ophthalmologica. 2006;220:393–396
43. Urade Y, Hayaishi O. Prostaglandin D synthase: structure and function. Vitam Horm. 2000;58:89–120.