Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 12, 2010, Pages 6431-6440

  Joos, Karen M ^a   Li, Chun ^b   Sappington, Rebecca M ^a  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AXOPLASM; CELL BODY; CELL SOMA NUMBER; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; DEVICE; HISTOPATHOLOGY; INTRAOCULAR PRESSURE ABNORMALITY; INTRAOCULAR PRESSURE ELEVATION; MALE; MORPHOMETRICS; MYELIN SHEATH; MYELINATION; NERVE FIBER; NERVE FIBER DEGENERATION; NERVE FIBER LAYER THICKNESS; NONHUMAN; OPTIC NERVE; PNEUMATONOMETER; PRESSURE MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETINA GANGLION CELL; THICKNESS;

ANIMALS; AXONS; CELL COUNT; DISEASE MODELS, ANIMAL; GLAUCOMA; INTRAOCULAR PRESSURE; MALE; NERVE DEGENERATION; OCULAR HYPERTENSION; OPTIC NERVE; OPTIC NERVE DISEASES; RATS; RATS, SPRAGUE-DAWLEY; RETINAL GANGLION CELLS; TONOMETRY, OCULAR;

EID: 79955961697     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5212     Document Type: Article

References (64)

1. Konstas AG, Maskaleris G, Gratsonidis S, Sardelli C. Compliance and viewpoint of glaucoma patients in Greece. Eye. 2000;14(5):752-756.
2. Sleath B, Robin AL, Covert D, Byrd JE, Tudor G, Svarstad B. Patient-reported behavior and problems in using glaucoma medications. Ophthalmology. 2006;113(3):431-436.
3. Henderer JD, Wilson RP, Moster MR, et al. Timolol/dorzolamide combination therapy as initial treatment for intraocular pressure over 30 mm Hg. J Glaucoma. 2005;14(4):267-270.
4. Carlson KH, McLaren JW, Topper JE, Brubaker RF. Effect of body position on intraocular pressure and aqueous flow. Invest Ophthalmol Vis Sci. 1987;28(8):1346-1352.
5. Weinreb RN, Cook J, Friberg TR. Effect of inverted body position on intraocular pressure. Am J Ophthalmol. 1984;98(6):784-787.
6. Drance SM. The significance of the diurnal tension variations in normal and glaucomatous eyes. Arch Ophthalmol. 1960;64:494-501.
7. Liu JH, Zhang X, Kripke DF, Weinreb RN. Twenty-four-hour intraocular pressure pattern associated with early glaucomatous changes. Invest Ophthalmol Vis Sci. 2003;44(4):1586-1590.
8. Mosaed S, Liu JH, Weinreb RN. Correlation between office and peak nocturnal intraocular pressures in healthy subjects and glaucoma patients. Am J Ophthalmol. 2005;139(2):320-324.
9. Hara T, Hara T, Tsuru T. Increase of peak intraocular pressure during sleep in reproduced diurnal changes by posture. Arch Ophthalmol. 2006;124(2):165-168.
10. Zeimer RC, Wilensky JT, Gieser DK, Viana MA. Association between intraocular pressure peaks and progression of visual field loss. Ophthalmology. 1991;98(1):64-69.
11. Hughes E, Spry P, Diamond J. 24-Hour monitoring of intraocular pressure in glaucoma management: a retrospective review. J Glaucoma. 2003;12(3):232-236.
12. Sung VC, Barton K. Management of inflammatory glaucomas. Curr Opin Ophthalmol. 2004;15(2):136-140.
13. Bui CM, Chen H, Shyr Y, Joos KM. Discontinuing nasal steroids might lower intraocular pressure in glaucoma. J Allergy Clin Immunol. 2005;116(5):1042-1047.
14. Kitazawa Y, Horie T. Diurnal variation of intraocular pressure in primary open-angle glaucoma. Am J Ophthalmol. 1975;79(4):557-566.
15. Konstas AG, Topouzis F, Leliopoulou O, et al. 24-hour intraocular pressure control with maximum medical therapy compared with surgery in patients with advanced open-angle glaucoma. Ophthalmology. 2006;113(5):761-765.
16. Bergea B, Bodin L, Svedbergh B. Impact of intraocular pressure regulation on visual fields in open-angle glaucoma. Ophthalmology. 1999;106(5):997-1004.
17. Nouri-Mahdavi K, Hoffman D, Coleman AL, et al. Advanced Glaucoma Intervention Study: predictive factors for glaucomatous visual field progression in the Advanced Glaucoma Intervention Study. Ophthalmology. 2004;111(9):1627-1623.
18. Shareef SR, Garcia-Valenzuela E, Salierno A, Walsh J, Sharma SC. Chronic ocular hypertension following episcleral venous occlusion in rats. Exp Eye Res. 1995;61(3):379-382.
19. Morrison JC, Moore CG, Deppmeier LMH, Gold BG, Meshul CK, Johnson EC. A rat model of chronic pressure-induced optic nerve damage. Exp Eye Res. 1997;64(1):85-96.
20. John SW, Smith RS, Savinova OV, et al. Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice. Invest Ophthalmol Vis Sci. 1998;39(6):951-962.
21. Johnson EC, Deppmeier LM, Wentzien SK, Hsu I, Morrison JC. Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest Ophthalmol Vis Sci. 2000;41(2):431-442.
22. Goldblum D, Mittag T. Prospects for relevant glaucoma models with retinal ganglion cell damage in the rodent eye. Vision Res. 2002;42(4):471-478.
23. Levkovitch-Verbin H, Quigley HA, Martin KR, Valenta D, Baumrind LA, Pease ME. Translimbal laser photocoagulation to the trabecular meshwork as a model of glaucoma in rats. Invest Ophthalmol Vis Sci. 2002;43(2):402-410.
24. Morrison JC. Elevated intraocular pressure and optic nerve injury models in the rat. J Glaucoma. 2005;14(4):315-317.
25. Inman DM, Sappington RM, Horner PJ, Calkins DJ. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2006;47(3):986-996.
26. Naskar R, Thanos S. Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure. Mol Vis. 2006;12:1199-1210.
27. Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and asymmetric. BMC Neurosci. 2006;7:66.
28. Pang IH, Clark AF. Rodent models for glaucoma retinopathy and optic neuropathy. J Glaucoma. 2007;16(5):483-505.
29. Nissirios N, Chanis R, Johnson E, et al. Comparison of anterior segment structures in two rat glaucoma models: an ultrasound biomicroscopic study. Invest Ophthalmol Vis Sci. 2008;49(6):2478-2482.
30. Buckingham BP, Inman DM, Lambert W, et al. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J Neurosci. 2008;28(11):2735-2744.
31. McKinnon SJ, Schlamp CL, Nickells RW. Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res. 2009;88(4):816-824.
32. Jia L, Cepurna WO, Johnson EC, Morrison JC. Patterns of intraocular pressure elevation after aqueous humor outflow obstruction in rats. Invest Ophthalmol Vis Sci. 2000;41(6):1380-1385.
33. Foulds WS, Johnson NF. Rabbit electroretinogram during recovery from induced ischemia. Trans Ophthalmol Soc UK. 1974;94(2):383-393.
34. Selles-Navarro I, Villegas-Perez MP, Salvador-Silva M, Ruiz-Gomez JM, Vidal-Sanz M. Retinal ganglion cell death after different transient periods of pressure-induced ischemia and survival intervals. Invest Ophthalmol Vis Sci. 1996;37(10):2002-2014.
35. Bui BV, Edmunds B, Cioffi GA, Fortune B. The gradient of retinal functional changes during acute intraocular pressure elevation. Invest Ophthalmol Vis Sci. 2005;46(1):202-213.
36. Morrison JC, Johnson EC, Cepurna W, Jia L. Understanding mechanisms of pressure-induced optic nerve damage. Prog Retin Eye Res. 2005;24(2):217-240.
37. Laquis S, Chaudhary P, Sharma SC. The patterns of retinal ganglion cell death in hypertensive eyes. Brain Res. 1998;784(1):100-104.
38. Kawaguchi I, Higashide T, Ohkubo S, et al. In vivo imaging and quantitative evaluation of the rat retinal nerve fiber layer using scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 2006;47:2911-2916.
39. Zhang X, Chintala SK. Influence of interleukin-1 beta induction and mitogen-activated protein kinase phosphorylation on optic nerve ligation-induced matrix metalloproteinase-9 activation in the retina. Exp Eye Res. 2004;78:849-860.
40. Sappington RM, Carlson BJ, Crish SD, Calkins DJ. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest Ophthalmol Vis Sci. 2010;51(1):207-216.
41. Baltan S, Inman DM, Danilov CA, Morrison RS, Calkins DJ, Horner PJ. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J Neurosci. 2010;30(16):5644-5652.
42. Cepurna WO, Kayton RJ, Johnson EC, Morrison JC. Age related optic nerve axonal loss in adult Brown Norway rats. Exp Eye Res. 2005;80(6):877-884.
43. Jonas JB, Schmidt AM, Müller-Bergh JA, Naumann GO. Optic nerve fiber count and diameter of the retrobulbar optic nerve in normal and glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol. 1995;233(7):421-424.
44. Mabuchi F, Aihara M, Mackey MR, Lindsey JD, Weinreb RN. Optic nerve damage in experimental mouse ocular hypertension. Invest Ophthalmol Vis Sci. 2003;44(10):4321-4330.
45. Ito Y, Shimazawa M, Chen YN, et al. Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. Exp Eye Res. 2009;89(2):246-255.
46. Vanezis P, Chan KK, Scholtz CL. White matter damage following acute head injury. Forensic Sci Int. 1987;35(1):1-10.
47. Takamiya Y, Kohsaka S, Toya S, Otani M, Tsukada Y. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats. Brain Res. 1988;466(2):201-210.
48. Hatten ME, Liem RK, Shelanski ML, Mason CA. Astroglia in CNS injury. Glia. 1991;4(2):233-243.
49. Varela HJ, Hernandez MR. Astrocyte responses in human optic nerve head with primary open-angle glaucoma. J Glaucoma. 1997;6(5):303-313.
50. Joos KM, Mawn LA, Shen JH, Casagrande VA. Chronic and acute analysis of optic nerve sheath fenestration with the free electron laser in monkeys. Lasers Surg Med. 2003;32(1):32-41.
51. Jia L, Cepurna WO, Johnson EC, Morrison JC. Effect of general anesthetics on IOP in rats with experimental aqueous outflow obstruction. Invest Ophthalmol Vis Sci. 2000;41(11):3415-3419.
52. Ueda J, Sawaguchi S, Hanyu T, et al. Experimental glaucoma model in the rat induced by laser trabecular photocoagulation after an intracameral injection of India ink. Jpn J Ophthalmol. 1998;42(5):337-344.
53. Pease ME, McKinnon SJ, Quigley HA, Kerrigan-Baumrind LA, Zack DJ. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci. 2000;41(3):764-774.
54. Saggu SK, Chotaliya HP, Cai Z, Blumbergs P, Casson RJ. The spatiotemporal pattern of soma and axonal pathology after perikaryal excitotoxic injury to retinal ganglion cells: a histological and morphometric study. Exp Neurol. 2008;211(1):52-58.
55. Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc Natl Acad Sci U S A. 2010;107(11):5196-5201.
56. Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci. 2006;47(7):2932-2942.
57. Schlamp CL, Li Y, Dietz JA, Janssen KT, Nickells RW. Progressive ganglion cell loss and optic nerve degeneration in DBA/2J mice is variable and progressive. BMC Neurosci. 2006;7:66.
58. Hunter A, Bedi KS. A quantitative morphological study of interstrain variation in the developing rat optic nerve. J Comp Neurol. 1986;245(2):160-166.
59. Ricci A, Bronzetti E, Amenta F. Effect of ageing on the nerve fibre population of rat optic nerve. Gerontology. 1988;34(5-6):231-235.
60. Sugimoto T, Fukuda Y, Wakakuwa K. Quantitative analysis of a cross-sectional area of the optic nerve: a comparison between albino and pigmented rats. Exp Brain Res. 1984;54(2):266-274.
61. Chauhan BC, LeVatte TL, Garnier KL, et al. Semiquantitative optic nerve grading scheme for determining axonal loss in experimental optic neuropathy. Invest Ophthalmol Vis Sci. 2006;47(2):634-640.
62. Lam TT, Kwong JM, Tso MO. Early glial responses after acute elevated intraocular pressure in rats. Invest Ophthalmol Vis Sci. 2003;44(2):638-645.
63. Hernandez MR. The optic nerve head in glaucoma: role of astrocytes in tissue remodeling. Prog Retin Eye Res. 2000;19(3):297-321.
64. Furuyoshi N, Furuyoshi M, May CA, Hayreh SS, Alm A, Lutjen-Drecoll E. Vascular and glial changes in the retrolaminar optic nerve in glaucomatous monkey eyes. Ophthalmologica. 2000;214(1):24-32.