Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool during Effective HIV Therapy

Journal of Infectious Diseases

Volumn 212, Issue 4, 2015, Pages 596-607

  Von Stockenstrom, Susanne ^a,b   Odevall, Lina ^a   Lee, Eunok ^c,d   Sinclair, Elizabeth ^e   Bacchetti, Peter ^f   Killian, Maudi ^e   Epling, Lorrie ^e   Shao, Wei ^g   Hoh, Rebecca ^e   Ho, Terence ^e   Faria, Nuno R ⁱ   Lemey, Philippe ⁱ   Albert, Jan ^a,b   Hunt, Peter ^e   Loeb, Lisa ^e   Pilcher, Christopher ^e   Poole, Lauren ^e   Hatano, Hiroyu ^e   Somsouk, Ma ^e   Douek, Daniel ^h   Boritz, Eli ^h   Deeks, Steven G ^e   Hecht, Frederick M ^e   Palmer, Sarah ^a,c,d   more..

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c WESTMEAD HOSPITAL   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e Department of Medicine ^*  (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^h NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

ⁱ REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

HIV 1 persistence; HIV 1 reservoir; memory T cells

Indexed keywords

VIRUS DNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ARTICLE; BLOOD; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INTESTINE LYMPHATIC TISSUE; LONGEVITY; LONGITUDINAL STUDY; LYMPH NODE; MEMORY T LYMPHOCYTE; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIRUS GENOME; VIRUS REPLICATION; CYTOLOGY; GENETICS; HIV INFECTIONS; ISOLATION AND PURIFICATION; PHYSIOLOGY; VIROLOGY;

ANTI-HIV AGENTS; CELL PROLIFERATION; DNA, VIRAL; HIV INFECTIONS; HIV-1; HUMANS; LONGITUDINAL STUDIES; LYMPH NODES; PHYLOGENY; T-LYMPHOCYTE SUBSETS;

EID: 84939625364     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv092     Document Type: Article

References (18)

1. Buzon MJ, Massanella M, Llibre JM, et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAARTsuppressed subjects. Nat Med 2010; 16:460-5.
2. Yukl SA, Shergill AK, McQuaid K, et al. Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapy. AIDS 2010; 24:2451-60.
3. Josefsson L, von Stockenstrom S, Faria NR, et al. The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci USA 2013; 110:E4987-96.
4. Chomont N, Da Fonseca S, Vandergeeten C, Ancuta P, Sekaly RP. Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV. Curr Opin HIV AIDS 2011; 6:30-6.
5. Chomont N, El-Far M, Ancuta P, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009; 15:893-900.
6. Josefsson L, Eriksson S, Sinclair E, et al. Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis 2012; 206:28-34.
7. Palmer S, Kearney M, Maldarelli F, et al. Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatmentexperienced patients are missed by standard genotype analysis. J Clin Microbiol 2005; 43:406-13.
8. Kearney M, Maldarelli F, Shao W, et al. Human immunodeficiency virus type 1 population genetics and adaptation in newly infected individuals. J Virol 2009; 83:2715-27.
9. Kearney M, Palmer S, Maldarelli F, et al. Frequent polymorphism at drug resistance sites in HIV-1 protease and reverse transcriptase. AIDS 2008; 22:497-501.
10. Drummond AJ, Suchard MA, Xie D, Rambaut A. Bayesian phylogenetics with BEAUti and the BEAST 1.7. Mol Biol Evol 2012; 29:1969-73.
11. Gunthard HF, Havlir DV, Fiscus S, et al. Residual human immunodeficiency virus (HIV) Type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years. J Infect Dis 2001; 183:1318-27.
12. Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4+ T cells. Pathol Biol 2003; 51:64-6.
13. Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med 2003; 198:1797-806.
14. Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V. Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS Pathog 2011; 7:e1002288.
15. Macallan DC, Wallace D, Zhang Y, et al. Rapid turnover of effectormemory CD4(+) T cells in healthy humans. J Exp Med 2004; 200: 255-60.
16. Breton G, Chomont N, Takata H, et al. Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection. J Immunol 2013; 191:2194-204.
17. Maldarelli F, Wu X, Su L, et al. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. Science 2014; 345:179-83.
18. Wagner TA, McLaughlin S, Garg K, et al. HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection. Science 2014; 345:570-3.