Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA

Journal of Infectious Diseases

Volumn 206, Issue 1, 2012, Pages 28-34

  Josefsson, Lina ^a,b   Eriksson, Susanne ^a,b   Sinclair, Elizabeth ^c   Ho, Terence ^c   Killian, Maudi ^c   Epling, Lorrie ^c   Shao, Wei ^e   Lewis, Bradley ^c   Bacchetti, Peter ^d   Loeb, Lisa ^c   Custer, Jeff ^c   Poole, Lauren ^c   Hecht, Frederick M ^c   Palmer, Sarah ^a,b  

^a Swedish Institute for Communicable Disease Control   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ARTICLE; BONE MARROW; CELL COMPARTMENTALIZATION; CLINICAL ARTICLE; DISEASE CONTROL; DNA SEQUENCE; GENETIC VARIABILITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOID CELL; MEMORY CD4+ T LYMPHOCYTE; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; VIRUS DETECTION; VIRUS GENOME; VIRUS ISOLATION; VIRUS LOAD;

ANTIGENS, CD34; BONE MARROW; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; DNA, VIRAL; HEMATOPOIETIC STEM CELLS; HIV INFECTIONS; HIV-1; HUMANS; PHYLOGENY; VIRAL LOAD;

EID: 84861559237     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis301     Document Type: Article

References (14)

1. Dornadula G, Zhang H, VanUitert B, et al. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. JAMA 1999; 282:1627-32.
2. Havlir DV, Koelsch KK, Strain MC, et al. Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine. J Infect Dis 2005; 191:1164-8.
3. Maldarelli F, Palmer S, King MS, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog 2007; 3:e46.
4. Zhang L, Ramratnam B, Tenner-Racz K, et al. Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 1999; 340:1605-13.
5. Lewin SR, Vesanen M, Kostrikis L, et al. Use of real-time PCR and molecular beacons to detect virus replication in human immunodeficiency virus type 1-infected individuals on prolonged effective antiretroviral therapy. J Virol 1999; 73:6099-103.
6. Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-300.
7. Marsden MD, Zack JA. Eradication of HIV: current challenges and new directions. J Antimicrob Chemother 2009; 63:7-10.
8. Brennan TP, Woods JO, Sedaghat AR, Siliciano JD, Siliciano RF, Wilke CO. Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J Virol 2009; 83:8470-81.
9. Bailey JR, Sedaghat AR, Kieffer T, et al. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 2006; 80:6441-57.
10. Carter CC, Onafuwa-Nuga A, McNamara LA, et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med 2010; 16:446-51.
11. Josefsson L, King MS, Makitalo B, et al. Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proc Natl Acad Sci USA 2011; 108:11199-204.
12. Brinchmann JE, Albert J, Vartdal F. Few infected CD4+ T cells but a high proportion of replication-competent provirus copies in asymptomatic human immunodeficiency virus type 1 infection. J Virol 1991; 65:2019-23.
13. Palmer S, Kearney M, Maldarelli F, et al. Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatmentexperienced patients are missed by standard genotype analysis. J Clin Microbiol 2005; 43:406-13.
14. Redd AD, Avalos A, Essex M. Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa. Blood 2007; 110:3143-9.