Changes in mitochondrial morphology and bioenergetics in human lymphoblastoid cells with four novel opa1 mutations

Investigative Ophthalmology and Visual Science

Volumn 56, Issue 4, 2015, Pages 2269-2278

  Kao, Shu Huei ^a   Yen, May Yung ^b,c   Wang, An Guor ^b,c   Yeh, Yi Ling ^a   Lin, An Lo ^a,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Autosomal dominant optic atrophy; Mitochondrial bioenergetics; Mitochondrial network; OPA1

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHAPERONIN 60; ISOPROTEIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; GUANOSINE TRIPHOSPHATASE; OPA1 PROTEIN, HUMAN;

ARTICLE; AUTOSOMAL DOMINANT OPTIC ATROPHY; BIOENERGY; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FLOW CYTOMETRY; GENE; GENE MUTATION; GENETIC VARIABILITY; GLYCOLYSIS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; MALE; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OPTIC ATROPHY 1 GENE; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PEDIGREE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; APOPTOSIS; CELL CULTURE; ENERGY METABOLISM; GENETICS; METABOLISM; MIDDLE AGED; MITOCHONDRION; MUTATION; PATHOLOGY; PEDIGREE;

APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; ENERGY METABOLISM; FEMALE; FLOW CYTOMETRY; GTP PHOSPHOHYDROLASES; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MITOCHONDRIA; MUTATION; OPTIC ATROPHY, AUTOSOMAL DOMINANT; PEDIGREE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84939623351     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.14-16288     Document Type: Article

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