Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci of STAT4 and HLA-DQ in a Korean population

Infection, Genetics and Evolution

Volumn 33, Issue , 2015, Pages 72-76

  Kim, Lyoung Hyo ^a,b   Cheong, Hyun Sub ^b   Namgoong, Suhg ^a,b   Kim, Ji On ^b   Kim, Jeong Hyun ^a   Park, Byung Lae ^b   Cho, Sung Won ^c   Park, Neung Hwa ^d   Cheong, Jae Youn ^c   Koh, InSong ^e   Shin, Hyoung Doo ^a,b   Kim, Yoon Jun ^f  

^a Sogang University   (South Korea)

^b SNP Genetics Inc   (South Korea)

^c Ajou University School of Medicine   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e Hanyang University   (South Korea)

^f Seoul National University   (South Korea)

Author keywords

Chronic hepatitis B virus; Hepatocellular carcinoma; HLA DQ; STAT4

Indexed keywords

DNA; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; MESSENGER RNA; STAT4 PROTEIN; HLA DQ ANTIGEN;

ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HLA DQA1 GENE; HLA DQB1 GENE; HUMAN; HUMAN TISSUE; KOREAN (PEOPLE); LIVER CELL CARCINOMA; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; POPULATION GENETICS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STAT4 GENE; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CASE CONTROL STUDY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; LIVER NEOPLASMS; MALE; RISK FACTOR; SOUTH KOREA;

HEPATITIS B VIRUS;

ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REPUBLIC OF KOREA; RISK FACTORS; STAT4 TRANSCRIPTION FACTOR;

EID: 84939598950     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2015.04.013     Document Type: Article

References (16)

1. Brechot C., Gozuacik D., Murakami Y., Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin. Cancer Biol. 2000, 10:211-231.
2. But D.Y., Lai C.L., Yuen M.F. Natural history of hepatitis-related hepatocellular carcinoma. World J. Gastroenterol. 2008, 14:1652-1656.
3. Chen K., Shi W., Xin Z., Wang H., Zhu X., Wu X., Li Z., Li H., Liu Y. Replication of genome wide association studies on hepatocellular carcinoma susceptibility Loci in a Chinese population. PLoS One 2013, 8:e77315.
4. Clark A., Gerlach F., Tong H., Hoan N.X., Song le H., Toan N.L., Bock C.T., Kremsner P.G., Velavan T.P. A trivial role of STAT4 variant in chronic hepatitis B induced hepatocellular carcinoma. Infect. Genet. Evol. 2013, 18:257-261.
5. Jiang D.K., Sun J., Cao G., Liu Y., Lin D., Gao Y.Z., Ren W.H., Long X.D., Zhang H., Ma X.P., Wang Z., Jiang W., Chen T.Y., Gao Y., Sun L.D., Long J.R., Huang H.X., Wang D., Yu H., Zhang P., Tang L.S., Peng B., Cai H., Liu T.T., Zhou P., Liu F., Lin X., Tao S., Wan B., Sai-Yin H.X., Qin L.X., Yin J., Liu L., Wu C., Pei Y., Zhou Y.F., Zhai Y., Lu P.X., Tan A., Zuo X.B., Fan J., Chang J., Gu X., Wang N.J., Li Y., Liu Y.K., Zhai K., Hu Z., Liu J., Yi Q., Xiang Y., Shi R., Ding Q., Zheng W., Shu X.O., Mo Z., Shugart Y.Y., Zhang X.J., Zhou G., Shen H., Zheng S.L., Xu J., Yu L. Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat. Genet. 2013, 45:72-75.
6. Kamatani Y., Wattanapokayakit S., Ochi H., Kawaguchi T., Takahashi A., Hosono N., Kubo M., Tsunoda T., Kamatani N., Kumada H., Puseenam A., Sura T., Daigo Y., Chayama K., Chantratita W., Nakamura Y., Matsuda K. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nat. Genet. 2009, 41:591-595.
7. Kim Y.J., Kim H.Y., Lee J.H., Yu S.J., Yoon J.H., Lee H.S., Kim C.Y., Cheong J.Y., Cho S.W., Park N.H., Park B.L., Namgoong S., Kim L.H., Cheong H.S., Shin H.D. A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. Hum. Mol. Genet. 2013, 22:4233-4238.
8. Li S., Qian J., Yang Y., Zhao W., Dai J., Bei J.X., Foo J.N., McLaren P.J., Li Z., Yang J., Shen F., Liu L., Pan S., Wang Y., Li W., Zhai X., Zhou B., Shi L., Chen X., Chu M., Yan Y., Wang J., Cheng S., Shen J., Jia W., Liu J., Wen Z., Li A., Zhang Y., Zhang G., Luo X., Qin H., Chen M., Wang H., Jin L., Lin D., Shen H., He L., de Bakker P.I., Zeng Y.X., Wu M., Hu Z., Shi Y., Zhou W. GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers. PLoS Genet. 2012, 8:e1002791.
9. Mbarek H., Ochi H., Urabe Y., Kumar V., Kubo M., Hosono N., Takahashi A., Kamatani Y., Miki D., Abe H., Tsunoda T., Kamatani N., Chayama K., Nakamura Y., Matsuda K. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum. Mol. Genet. 2011, 20:3884-3892.
10. Nishida N., Sawai H., Matsuura K., Sugiyama M., Ahn S.H., Park J.Y., Hige S., Kang J.H., Suzuki K., Kurosaki M., Asahina Y., Mochida S., Watanabe M., Tanaka E., Honda M., Kaneko S., Orito E., Itoh Y., Mita E., Tamori A., Murawaki Y., Hiasa Y., Sakaida I., Korenaga M., Hino K., Ide T., Kawashima M., Mawatari Y., Sageshima M., Ogasawara Y., Koike A., Izumi N., Han K.H., Tanaka Y., Tokunaga K., Mizokami M. Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean. PLoS One 2012, 7:e39175.
11. Perz J.F., Armstrong G.L., Farrington L.A., Hutin Y.J., Bell B.P. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J. Hepatol. 2006, 45:529-538.
12. Pungpapong S., Kim W.R., Poterucha J.J. Natural history of hepatitis B virus infection: an update for clinicians. Mayo Clin. Proc. 2007, 82:967-975.
13. Thursz M. Genetic susceptibility in chronic viral hepatitis. Antiviral Res. 2001, 52:113-116.
14. Wang F.S. Current status and prospects of studies on human genetic alleles associated with hepatitis B virus infection. World J. Gastroenterol. 2003, 9:641-644.
15. Yang J.D., Roberts L.R. Hepatocellular carcinoma: a global view. Nat. Rev. Gastroenterol. Hepatol. 2010, 7:448-458.
16. Zhang H., Zhai Y., Hu Z., Wu C., Qian J., Jia W., Ma F., Huang W., Yu L., Yue W., Wang Z., Li P., Zhang Y., Liang R., Wei Z., Cui Y., Xie W., Cai M., Yu X., Yuan Y., Xia X., Zhang X., Yang H., Qiu W., Yang J., Gong F., Chen M., Shen H., Lin D., Zeng Y.X., He F., Zhou G. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nat. Genet. 2010, 42(9):755-758.