Elastomeric Cell-Laden Nanocomposite Microfibers for Engineering Complex Tissues

Cellular and Molecular Bioengineering

Volumn 8, Issue 3, 2015, Pages 404-415

  Peak, Charles W ^a   Carrow, James K ^a   Thakur, Ashish ^a   Singh, Ankur ^b   Gaharwar, Akhilesh K ^a,c  

^a Texas A M University   (United States)

^b School of Operations Research and Industrial Engineering   (United States)

^c Department of Electrical and Computer Engineering   (United States)

Author keywords

Bioadhesive; Cell matrix interactions; Microfibers; Nanocomposite hydrogels; Nanoparticles; Tissue engineering

Indexed keywords

DIACRYLATE; ELASTOMER; MACROGOL; METHACRYLIC ACID; MOLECULAR SCAFFOLD; NANOCOMPOSITE; NANOPARTICLE; SILICATE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL PROLIFERATION; CELL SPREADING; CELL SURVIVAL; CHEMICAL INTERACTION; CROSS LINKING; DEGRADATION; MECHANICAL STRESS; NANOFABRICATION; PRIORITY JOURNAL; TISSUE ENGINEERING; VISCOELASTICITY;

EID: 84939565838     PISSN: 18655025     EISSN: 18655033     Source Type: Journal    
DOI: 10.1007/s12195-015-0406-7     Document Type: Article

References (42)

1. Annabi, N., J. W. Nichol, X. Zhong, C. Ji, S. Koshy, A. Khademhosseini, and F. Dehghani. Controlling the porosity and microarchitecture of hydrogels for tissue engineering. Tissue Eng. B 16(4):371–383, 2010.
2. Carrow, J. K., and A. K. Gaharwar. Bioinspired polymeric nanocomposites for regenerative medicine. Macromol. Chem. Phys. 216(3):248, 2015.
3. Cayrol, F., M. C. Diaz Flaque, T. Fernando, S. N. Yang, H. A. Sterle, M. Bolontrade, M. Amoros, B. Isse, R. N. Farias, H. Ahn, Y. F. Tian, F. Tabbo, A. Singh, G. Inghirami, L. Cerchietti, and G. A. Cremaschi. Integrin alphavbeta3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells. Blood 125(5):841–851, 2015.
4. Chan, B. K., C. C. Wippich, C.-J. Wu, P. M. Sivasankar, and G. Schmidt. Robust and semi-interpenetrating hydrogels from poly(ethylene glycol) and collagen for elastomeric tissue scaffolds. Macromol. Biosci. 12(11):1490–1501, 2012.
5. Chaudhuri, O., S. T. Koshy, C. B. da Cunha, J. W. Shin, C. S. Verbeke, K. H. Allison, and D. J. Mooney. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat. Mater. 13(10):970–978, 2014.
6. Coyer, S. R., A. Singh, D. W. Dumbauld, D. A. Calderwood, S. W. Craig, E. Delamarche, and A. J. García. Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J. Cell Sci. 125(21):5110–5123, 2012.
7. Dumbauld, D. W., T. T. Lee, A. Singh, J. Scrimgeour, C. A. Gersbach, E. A. Zamir, J. Fu, C. S. Chen, J. E. Curtis, and S. W. Craig. How vinculin regulates force transmission. Proc. Natl. Acad. Sci. 110(24):9788–9793, 2013.
8. Dvir, T., B. P. Timko, D. S. Kohane, and R. Langer. Nanotechnological strategies for engineering complex tissues. Nat. Nanotechnol. 6(1):13–22, 2011.
9. Gaharwar, A. K., R. K. Avery, A. Assmann, A. Paul, G. H. McKinley, A. Khademhosseini, and B. D. Olsen. Shear-thinning nanocomposite hydrogels for the treatment of hemorrhage. ACS Nano 8(10):9833–9842, 2014.
10. Gaharwar, A. K., V. Kishore, C. Rivera, W. Bullock, C. J. Wu, O. Akkus, and G. Schmidt. Physically crosslinked nanocomposites from silicate-crosslinked peo: mechanical properties and osteogenic differentiation of human mesenchymal stem cells. Macromol. Biosci. 12(6):779–793, 2012.
11. Gaharwar, A. K., S. M. Mihaila, A. Swami, A. Patel, S. Sant, R. L. Reis, A. P. Marques, M. E. Gomes, and A. Khademhosseini. Bioactive silicate nanoplatelets for osteogenic differentiation of human mesenchymal stem cells. Adv. Mater. 25(24):3329–3336, 2013.
12. Gaharwar, A. K., N. A. Peppas, and A. Khademhosseini. Nanocomposite hydrogels for biomedical applications. Biotechnol. Bioeng. 111(3):441–453, 2014.
13. Gaharwar, A. K., P. J. Schexnailder, A. Dundigalla, J. D. White, C. R. Matos-Pérez, J. L. Cloud, S. Seifert, J. J. Wilker, and G. Schmidt. Highly extensible bio-nanocomposite fibers. Macromol. Rapid Commun. 32(1):50–57, 2011.
14. Gaharwar, A. K., P. J. Schexnailder, B. P. Kline, and G. Schmidt. Assessment of using Laponite® cross-linked poly(ethylene oxide) for controlled cell adhesion and mineralization. Acta Biomater. 7(2):568–577, 2011.
15. Giano, M. C., Z. Ibrahim, S. H. Medina, K. A. Sarhane, J. M. Christensen, Y. Yamada, G. Brandacher, and J. P. Schneider. Injectable bioadhesive hydrogels with innate antibacterial properties. Nat. Commun. 5:4095, 2014.
16. Hern, D. L., and J. A. Hubbell. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J. Biomed. Mater. Res. 39(2):266–276, 1998.
17. Hoffman, A. S. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 64:18–23, 2012.
18. Hoffman, A. S. Stimuli-responsive polymers: Biomedical applications and challenges for clinical translation. Adv Drug Deliv Rev. 65(1):10–16, 2013.
19. Hutson, C. B., J. W. Nichol, H. Aubin, H. Bae, S. Yamanlar, S. Al-Haque, S. T. Koshy, and A. Khademhosseini. Synthesis and characterization of tunable poly(ethylene glycol): gelatin methacrylate composite hydrogels. Tissue Eng. A 17(13–14):1713–1723, 2011.
20. Karimi, A., and M. Navidbakhsh. Material properties in unconfined compression of gelatin hydrogel for skin tissue engineering applications. Biomed. Eng. Biomed. Tech. 59(6):479–486, 2014.
21. Kerativitayanan, P., J. K. Carrow, and A. K. Gaharwar. Nanomaterials for engineering stem cell responses. Adv. Healthc. Mater. 2015. doi:10.1002/adhm.201500272.
22. Lee, T. T., J. R. Garcia, J. I. Paez, A. Singh, E. A. Phelps, S. Weis, Z. Shafiq, A. Shekaran, A. Del Campo, and A. J. Garcia. Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials. Nat. Mater. 14(3):352–360, 2014.
23. Lee, K. Y., and D. J. Mooney. Hydrogels for tissue engineering. Chem. Rev. 101(7):1869–1880, 2001.
24. Liu, Y., H. Meng, S. Konst, R. Sarmiento, R. Rajachar, and B. P. Lee. Injectable dopamine-modified poly(ethylene glycol) nanocomposite hydrogel with enhanced adhesive property and bioactivity. Acs Appl. Mater. Interfaces 6(19):16982–16992, 2014.
25. Mellott, M. B., K. Searcy, and M. V. Pishko. Release of protein from highly cross-linked hydrogels of poly(ethylene glycol) diacrylate fabricated by UV polymerization. Biomaterials 22(9):929–941, 2001.
26. Mihaila, S. M., A. K. Gaharwar, R. L. Reis, A. Khademhosseini, A. P. Marques, and M. E. Gomes. The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets. Biomaterials 35(33):9087–9099, 2014.
27. Mooney, D. T., C. L. Mazzoni, C. Breuer, K. McNamara, D. Hern, J. P. Vacanti, and R. Langer. Stabilized polyglycolic acid fibre based tubes for tissue engineering. Biomaterials 17(2):115–124, 1996.
28. Nguyen, K. T., and J. L. West. Photopolymerizable hydrogels for tissue engineering applications. Biomaterials 23(22):4307–4314, 2002.
29. Nichol, J. W., S. T. Koshy, H. Bae, C. M. Hwang, S. Yamanlar, and A. Khademhosseini. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 31(21):5536–5544, 2010.
30. Patel, R. G., A. Purwada, L. Cerchietti, G. Inghirami, A. Melnick, A. K. Gaharwar, and A. Singh. microscale bioadhesive hydrogel arrays for cell engineering applications. Cell. Mol. Bioeng. 7(3):394–408, 2014.
31. Peak, C. W., S. Nagar, R. D. Watts, and G. Schmidt. Robust and degradable hydrogels from poly(ethylene glycol) and semi-interpenetrating collagen. Macromolecules 47(18):6408–6417, 2014.
32. Peak, C. W., J. J. Wilker, and G. Schmidt. A review on tough and sticky hydrogels. Colloid Polym. Sci. 291(9):2031–2047, 2013.
33. Peppas, N. A., P. Bures, W. Leobandung, and H. Ichikawa. Hydrogels in pharmaceutical formulations. Eur. J. Pharm. Biopharm. 50(1):27–46, 2000.
34. Peppas, N. A., J. Z. Hilt, A. Khademhosseini, and R. Langer. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv. Mater. 18(11):1345–1360, 2006.
35. Peppas, N. A., K. B. Keys, M. Torres-Lugo, and A. M. Lowman. Poly(ethylene glycol)-containing hydrogels in drug delivery. J. Control. Release 62(1–2):81–87, 1999.
36. Purwada, A., M. K. Jaiswal, H. Ahn, T. Nojima, D. Kitamura, A. K. Gaharwar, L. Cerchietti, and A. Singh. Ex vivo engineered immune organoids for controlled germinal center reactions. Biomaterials 63:24–34, 2015.
37. Qiu, Y., and K. Park. Environment-sensitive hydrogels for drug delivery. Adv Drug Deliv Rev. 64:49–60, 2012.
38. Santos, M. I., K. Tuzlakoglu, S. Fuchs, M. E. Gomes, K. Peters, R. E. Unger, E. Piskin, R. L. Reis, and C. J. Kirkpatrick. Endothelial cell colonization and angiogenic potential of combined nano- and micro-fibrous scaffolds for bone tissue engineering. Biomaterials 29(32):4306–4313, 2008.
39. Shingleton, W. D., D. J. Hodges, P. Brick, and T. E. Cawston. Collagenase: a key enzyme in collagen turnover. Biochem. Cell Biol. 74(6):759–775, 1996.
40. Singh, A., and N. A. Peppas. Hydrogels and scaffolds for immunomodulation. Adv. Mater. 26(38):6530–6541, 2014.
41. Ullm, S., A. Kruger, C. Tondera, T. P. Gebauer, A. T. Neffe, A. Lendlein, F. Jung, and J. Pietzsch. Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties. Biomaterials 35(37):9755–9766, 2014.
42. Xavier, J. R., T. Thakur, P. Desai, M. K. Jaiswal, N. Sears, E. Cosgriff-Hernandez, R. Kaunas, and A. K. Gaharwar. Bioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach. ACS Nano 9(3):3109–3118, 2015.