A novel alanine to serine substitution mutation in SoxS induces overexpression of efflux pumps and contributes to multidrug resistance in clinical Escherichia coli isolates

Journal of Antimicrobial Chemotherapy

Volumn 70, Issue 8, 2015, Pages 2228-2233

  Aly, Sherine A ^a   Boothe, Dawn M ^b   Suh, Sang Jin ^b  

^a Assiut University Faculty of Medicine   (Egypt)

^b AUBURN UNIVERSITY   (United States)

Author keywords

acrB; Fluoroquinolones; soxR; soxS

Indexed keywords

ACRB PROTEIN; ALANINE; CHLORAMPHENICOL; CIPROFLOXACIN; DOXYCYCLINE; ENROFLOXACIN; PARAQUAT; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SERINE; SOXR PROTEIN; SOXS PROTEIN; TRANSCRIPTION FACTOR SOX; UNCLASSIFIED DRUG; ACRB PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; MULTIDRUG RESISTANCE PROTEIN; SOXS PROTEIN, E COLI; TRANSACTIVATOR PROTEIN;

ALLELE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; CODON; CONTROLLED STUDY; DOG; ESCHERICHIA COLI; FECES MICROFLORA; GENE EXPRESSION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; MISSENSE MUTATION; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; PHYLOGENY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; ESCHERICHIA COLI INFECTION; FECES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; GENETIC SELECTION; GENETICS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; VETERINARY;

ALANINE; AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; DOGS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FECES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC COMPLEMENTATION TEST; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION, MISSENSE; REAL-TIME POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SELECTION, GENETIC; SERINE; TRANS-ACTIVATORS;

EID: 84939553148     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv105     Document Type: Article

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