Limited Efficacy of Antibacterial Vaccination Against Secondary Serotype 3 Pneumococcal Pneumonia Following Influenza Infection

Journal of Infectious Diseases

Volumn 212, Issue 3, 2015, Pages 445-452

  Metzger, Dennis W ^a   Furuya, Yoichi ^a   Salmon, Sharon L ^a   Roberts, Sean ^a   Sun, Keer ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

adaptive immunity; coinfection; influenza virus; innate immunity; pneumococcus; pneumonia; vaccination

Indexed keywords

FC RECEPTOR; PNEUMOCOCCUS VACCINE; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; BACTERIAL GROWTH; BONE MARROW CELL; CELL COUNT; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFICACY; FLOW CYTOMETRY; HUMORAL IMMUNITY; INFLUENZA; INFLUENZA VIRUS; INNATE IMMUNITY; LUNG CLEARANCE; MIXED INFECTION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; SURVIVAL; VACCINATION; ANIMAL; C57BL MOUSE; IMMUNOLOGY; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMONIA, PNEUMOCOCCAL; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID CELLS; ORTHOMYXOVIRIDAE INFECTIONS; PNEUMOCOCCAL VACCINES; PNEUMONIA, PNEUMOCOCCAL; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS;

EID: 84939518332     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv066     Document Type: Article

References (29)

1. Stiver HG. The threat and prospects for control of an influenza pandemic. Expert Rev Vaccines 2004; 3:35-42.
2. McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev 2006; 19:571-82.
3. Morens DM, Taubenberger JK, Fauci AS. Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J Infect Dis 2008; 198:962-70.
4. Kuiken T, Taubenberger JK. Pathology of human influenza revisited. Vaccine 2008; 26:D59-66.
5. Oswald NC, Shooter RA, Curwen MP. Pneumonia complicating Asian influenza. Br Med J 1958; 2:1305-11.
6. Hers JF, Masurel N, Mulder J. Bacteriology and histopathology of the respiratory tract and lungs in fatal Asian influenza. Lancet 1958; 2:1141-3.
7. Potter TA, Pabst LJ, Fiore AE. Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1)-United States, May-August 2009. MMWR Morb Mortal Wkly Rep 2009; 58:1071-4.
8. Fleming-Dutra KE, Taylor T, Link-Gelles R, et al. Effect of the 2009 influenza A (H1N1) pandemic on invasive pneumococcal pneumonia. J Infect Dis 2013; 207:1135-43.
9. Klugman KP, Madhi SA. Pneumococcal vaccines and flu preparedness. Science 2007; 316:49-50.
10. Sun K, Metzger DW. Inhibition of pulmonary antibacterial defense by interferon-? during recovery from influenza infection. Nat Med 2008; 14:558-64.
11. Sun K, Metzger DW. Influenza infection suppresses NADPH oxidasedependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant Staphylococcus aureus infection. J Immunol 2014; 192:3301-7.
12. Shahangian A, Chow EK, Tian X, et al. Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice. J Clin Invest 2009; 119:1910-20.
13. Nakamura S, Davis KM,Weiser JN. Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice. J Clin Invest 2011; 121:3657-65.
14. Didierlaurent A, Goulding J, Patel S, et al. Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med 2008; 205:323-9.
15. Goulding J, Godlee A, Vekaria S, Hilty M, Snelgrove R, Hussell T. Lowering the threshold of lung innate immune cell activation alters susceptibility to secondary bacterial superinfection. J Infect Dis 2011; 204: 1086-94.
16. Ghoneim HE, Thomas PG, McCullers JA. Depletion of alveolar macrophages during influenza infection facilitates bacterial super-infections. J Immunol 2013; 191:1250-9.
17. Kudva A, Scheller EV, Robinson KM, et al. Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice. J Immunol 2011; 186:1666-74.
18. Madhi SA, Klugman KP. A role for Streptococcus pneumoniae in virusassociated pneumonia. Nat Med 2004; 10:811-3.
19. Lynch JM, Briles DE, Metzger DW. Increased protection against pneumococcal disease by mucosal administration of conjugate vaccine plus interleukin-12. Infect Immun 2003; 71:4780-8.
20. Who Expert Committee on Biological Standardization. World Health Organ Tech Rep Ser 2005; 927:1-154.
21. Mina MJ, Klugman KP, McCullers JA. Live attenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice. J Infect Dis 2013; 208: 1281-5.
22. Janssen WJ, Barthel L, Muldrow A, et al. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med 2011; 184:547-60.
23. Seo SU, Kwon HJ, Ko HJ, et al. Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice. PLOS Pathog 2011; 7:e1001304.
24. Arredouani M, Yang Z, Ning Y, et al. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med 2004; 200:267-72.
25. Breslow-Deckman JM, Mattingly CM, Birket SE, et al. Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-?. J Immunol 2013; 191:1792-9.
26. Huber VC, Peltola V, Iverson AR, McCullers JA. Contribution of vaccine-induced immunity toward either the HA or the NA component of influenza viruses limits secondary bacterial complications. J Virol 2010; 84:4105-8.
27. Sun K, Ye J, Perez DR, Metzger DW. Seasonal FluMist vaccination induces cross-reactive T cell immunity against H1N1 (2009) influenza and secondary bacterial infections. J Immunol 2011; 186: 987-93.
28. Haynes L, Szaba FM, Eaton SM, et al. Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections. J Immunol 2012; 189:4921-9.
29. Mina MJ, McCullers JA, Klugman KP. Live attenuated influenza vaccine enhances colonization of Streptococcus pneumoniae and Staphylococcus aureus in mice. mBio 2014; 5:e01040-13.