Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa

Journal of Ophthalmology

Volumn 2015, Issue , 2015, Pages

  Sacchetti, Marta ^a   Mantelli, Flavio ^b   Merlo, Daniela ^c   Lambiase, Alessandro ^d  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Temple University   (United States)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84939511600     PISSN: 2090004X     EISSN: 20900058     Source Type: Journal    
DOI: 10.1155/2015/737053     Document Type: Review

References (35)

1. D. T. Hartong, E. L. Berson, and T. P. Dryja,"Retinitis pigmentosa"The Lancet, vol. 368, no. 9549, pp. 1795-1809, 2006
2. S. Grover, G. A. Fishman, R. J. Anderson et al. ,"Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older"Ophthalmology, vol. 106, no. 9, pp. 1780-1785, 1999
3. E. L. Berson, M. A. Sandberg, B. Rosner, D. G. Birch, and A. H. Hanson,"Natural course of retinitis pigmentosa over a threeyear interval"American Journal of Ophthalmology, vol. 99, no. 3, pp. 240-251, 1985
4. M. L. Naash, N. S. Peachey, Z.-Y. Li et al. ,"Light-induced acceleration of photoreceptor degeneration in transgenic mice expressingmutant rhodopsin"Investigative Ophthalmology and Visual Science, vol. 37, no. 5, pp. 775-782, 1996
5. E. M. Vingolo, M. Rocco, P. L. Grenga, S. Salvatore, and P. Pelaia,"Slowing the degenerative process, long lasting effect of hyperbaric oxygen therapy in retinitis pigmentosa"Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 246, no. 1, pp. 93-98, 2008
6. E. M. Vingolo, P. Pelaia, R. Forte, M. Rocco, C. Giusti, and E. Rispoli,"Does hyperbaric oxygen (HBO) delivery rescue retinal photoreceptors in retinitis pigmentosa?" Documenta Ophthalmologica, vol. 97, no. 1, pp. 33-39, 1998
7. C. Hamel,"Retinitis pigmentosa"Orphanet Journal of Rare Diseases, vol. 1, no. 1, article 40, 2006
8. E. L. Berson, B. Rosner, M. A. Sandberg et al. ,"A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa"Archives of Ophthalmology, vol. 111, no. 6, pp. 761-772, 1993
9. H. Bahrami, M. Melia, and G. Dagnelie,"Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]"BMC Ophthalmology, vol. 6, article 23, 2006
10. E. L. Berson, B. Rosner, M. A. Sandberg et al. ,"Clinical trial of lutein in patientswith retinitis pigmentosa receiving vitamin A"Archives of Ophthalmology, vol. 128, no. 4, pp. 403-411, 2010
11. Y. Rotenstreich, M. Belkin, S. Sadetzki et al. ,"Treatment with 9-cis beta-carotene-rich powder in patients with retinitis pigmentosa a randomized crossover trial"JAMA Ophthalmology, vol. 131, no. 8, pp. 985-992, 2013
12. A. Kumar, N. Midha, V. Gogia, S. Gupta, S. Sehra, and A. Chohan,"Efficacy of oral valproic acid in patients with retinitis pigmentosa"Journal of Ocular Pharmacology and Therapeutics, vol. 30, no. 7, pp. 580-586, 2014
13. M. Nakazawa, H. Ohguro, K. Takeuchi, Y. Miyagawa, T. Ito, and T. Metoki,"Effect of nilvadipine on central visual field in retinitis pigmentosa: a 30-month clinical trial"Ophthalmologica, vol. 225, no. 2, pp. 120-126, 2011
14. S. Merin, A. Obolensky, M. D. Farber, and I. Chowers,"A pilot study of topical treatment with an alpha2-Agonist in patients with retinal dystrophies"Journal of Ocular Pharmacology and Therapeutics, vol. 24, no. 1, pp. 80-86, 2008
15. D. G. Birch, R. G. Weleber, J. L. Duncan, G. J. Jaffe, andW. Tao,"Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa"American Journal of Ophthalmology, vol. 156, no. 2, pp. 283. e1-292. e1, 2013
16. M. Akiyama, Y. Ikeda, N. Yoshida et al. ,"Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa"Acta Ophthalmologica, vol. 92, no. 3, pp. e229-e234, 2014
17. E. L. Berson, B. Rosner, M. A. Sandberg, C. Weigel-DiFranco, and W. C. Willett,"γ-3 Intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A"Archives of Ophthalmology, vol. 130, no. 6, pp. 707-711, 2012
18. S. Yamamoto, T. Sugawara, A. Murakami et al. ,"Topical isopropyl unoprostone for retinitis pigmentosa: microperimetric results of the phase 2 clinical study"Ophthalmology and Therapy, vol. 1, no. 1, article 5, 2012
19. T. S. Aleman, J. L. Duncan, M. L. Bieber et al. ,"Macular pigment and lutein supplementation in retinitis pigmentosa and usher syndrome"Investigative Ophthalmology and Visual Science, vol. 42, no. 8, pp. 1873-1881, 2001
20. C. O. Harding, M. B. Gillingham, S. C. van Calcar, J. A. Wolff, J. N. Verhoeve, and M. D. Mills,"Docosahexaenoic acid and retinal function in children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency"Journal of Inherited Metabolic Disease, vol. 22, no. 3, pp. 276-280, 1999
21. V. Khavinson, M. Razumovsky, S. Trofimova, R. Grigorian, and A. Razumovskaya,"Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa"Neuroendocrinology Letters, vol. 23, no. 4, pp. 365-368, 2002
22. H. Pasantes-Morales, H. Quiroz, and O. Quesada,"Treatment with taurine, diltiazem, and vitamin E retards the progressive visual field reduction in retinitis pigmentosa: a 3-year follow-up study"Metabolic Brain Disease, vol. 17, no. 3, pp. 183-197, 2002
23. Y. Rotenstreich, D. Harats, A. Shaish, E. Pras, and M. Belkin,"Treatment of a retinal dystrophy, fundus albipunctatus, with oral 9-cis-γ-carotene"The British Journal of Ophthalmology, vol. 94, no. 5, pp. 616-621, 2010
24. S. L. Saltzman and C. Haig,"Treatment of retinitis pigmentosa with cod liver oil injection and placental implantation"Archives of Ophthalmology, vol. 43, no. 3, pp. 419-430, 1950
25. M. Nakazawa, Y. Suzuki, T. Ito, T. Metoki, T. Kudo, and H. Ohguro,"Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study"BioMed Research International, vol. 2013, Article ID 585729, 6 pages, 2013
26. E. L. Berson, B. Rosner, M. A. Sandberg et al. ,"Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses"Archives of Ophthalmology, vol. 122, no. 9, pp. 1306-1314, 2004
27. E. L. Berson, B. Rosner, M. A. Sandberg et al. ,"Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment"Archives of Ophthalmology, vol. 122, no. 9, pp. 1297-1305, 2004
28. A. Chatzinoff, E. Nelson, N. Stahl, and A. Clahane,"Eleven-CIS vitamin A in the treatment of retinitis pigmentosa. A negative study"Archives of Ophthalmology, vol. 80, no. 4, pp. 417-419, 1968
29. D. R. Hoffman, D. K. Hughbanks-Wheaton, N. S. Pearson et al. ,"Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX Trial): a randomized clinical trial"JAMA Ophthalmology, vol. 132, no. 7, pp. 866-873, 2014
30. D. R. Hoffman, K. G. Locke, D. H. Wheaton, G. E. Fish, R. Spencer, and D. G. Birch,"A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for Xlinked retinitis pigmentosa"The American Journal of Ophthalmology, vol. 137, no. 4, pp. 704-718, 2004
31. D. K. Hughbanks-Wheaton, D. G. Birch, G. E. Fish et al. ,"Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: the 4-year DHAX trial"Investigative Ophthalmology and Visual Science, vol. 55, no. 8, pp. 4958-4966, 2014
32. D. A. Newsome, F. C. Dorsey, J. G. May, D. R. Bergsma, andN. G. Bazan,"Ganglioside administration in retinitis pigmentosa"Journal of Ocular Pharmacology, vol. 3, no. 4, pp. 323-332, 1987
33. L. Sibulesky, K. C. Hayes, A. Pronczuk, C. Weigel-DiFranco, B. Rosner, and E. L. Berson," 7500 RE (25000 IU) vitamin A daily in adults with retinitis pigmentosa The American Journal of Clinical Nutrition 69. 4, 656-663, 1999
34. E. L. Berson, B. Rosner, M. A. Sandberg et al. ,"Vitamin A supplementation for retinitis pigmentosa"Archives of Ophthalmology, vol. 111, no. 11, pp. 1456-1459, 1993
35. D. R. Hoffman, J. C. DeMar, W. C. Heird, D. G. Birch, and R. E. Anderson,"Impaired synthesis of DHA in patients with Xlinked retinitis pigmentosa"Journal of Lipid Research, vol. 42, no. 9, pp. 1395-1401, 2001