An ELISA-based amperometric biosensor within a photo-patternable adhesive microfluidic channel

2015 IEEE 10th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2015

Volumn , Issue , 2015, Pages 76-81

  Li, Yan ^a,b,c   Van Roy, Willem ^a   Vereecken, Philippe M ^a,c   Lagae, Liesbet ^a,c  

^a IMEC   (Belgium)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

amperometric biosensor; convective redox cycling; microfluidics; photo patternable adhesive

Indexed keywords

ADHESIVES; CHEMICAL SENSORS; ENZYME ELECTRODES; FLUIDIC DEVICES; LAMINAR FLOW; MICROELECTRODES;

AMPEROMETRIC BIOSENSORS; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH QUALITY; INTERDIGITATED ELECTRODE ARRAYS; MICROFLUIDIC CHANNEL; REDOX CYCLING;

MICROFLUIDICS;

EID: 84939506471     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/NEMS.2015.7147377     Document Type: Conference Paper

References (21)

1. M. Hervas, M. A. Lopez, A. Escarpa, "Electrochemical immunosensing on board microfluidic chip platforms", Trends Anal. Chem., vol. 31, pp. 109-128, 2012.
2. M. A. G. Zevenbergen, D. Krapf, M. Zuiddam, S. G. Lemay, "Mesoscopic concentration fluctuations in a fluidic nanocavity detected by redox cycling, " Nano Lett., vol. 7, pp. 384-388, 2007.
3. O. Niwa, Y. Xu, H.B. Halsall, W.R. Heineman, "Small-volume voltammetric detection of 4-aminophenol with interdigitated array electrodes and its application to electrochemical enzyme immunoassay, " Anal. Chem., vol. 65, pp.1559-63, 1993.
4. A. J. Bard, J. A. Crayston, G. P. Kittlesen, T. V. Shea, M. S. Wrighton, "Digital Simulation of the Measured Electrochemical Response of Reversible Redox Couples at Microelectrode Arrays: Consequences Arising from Closely Spaced Ultramicroelectrodes, " Anal. Chem., vol. 58, pp.2321-2331, 1986.
5. M. A. G. Zevenbergen, B. L. Wolfrum, E. D. Goluch, P. S. Singh, S. G. Lemay, "Fast electron-transfer kinetics probed in nanofluidic channels, " J. Am. Chem. Soc., vol.131, pp.11471-11477, 2009.
6. A. René, C. Cugnet, D. Hauchard, and L. Authier, "Elaboration of screenprinted microelectrodes working as generator/collector and their use in a flow cell system, " Sensor. Actuat. B-Chem., vol. 174, pp. 225-230, 2012.
7. C. Amatore, N. Da Mota, C. Sella, and L. Thouin, "Theory and experiments of transport at channel microband electrodes under laminar flow. 3. Electrochemical detection at electrode arrays under steady state, " Anal. Chem., vol. 82, no. 19, pp. 2434-2440, 2010.
8. M. J. Anderson and R. M. Crooks, "High-efficiency generation-collection microelectrochemical platform for interrogating electroactive thin films, " Anal. Chem., vol. 86, pp. 9962-9969, 2014.
9. K. Ino, T. Goto, Y. Kanno, K.Y. Inoue, Y. Takahashi, H. Shiku, T. Matsue, "Droplet array on local redox cycling-based electrochemical (LRC-EC) chip device, " Lab Chip, vol. 14, pp. 787-794, 2014.
10. F. Hofmann, A. Frey, B. Holzapfl, M. Schienle, C. Paulus, P. Schindler-Bauer, D. Kuhlmeier, J. Krause, R. Hintsche, E. Nebling, J. Albers, W. Gumbrecht, K. Plehnert, G. Eckstein, R. Thewes, "Fully electronic DNA detection on a CMOS chip: device and process issues", in International Electron Devices Meeting (IEDM) Tech. Dig., 2002, pp. 488-491.
11. K. Hieda, T. Miyazaki, S. Peeters, B. Majeed, J. Loo, C. Liu, J. O. Callaghan, K. Jans, L. Lagae, P. Deshpande, "Photo-Patternable and Adhesive Polymer for Wafer-Scale Microfluidic Device Fabrication, " JSR Technical Review, vol. 121, pp. 16-21, 2014.
12. J. C. Mcdonald, D. C. Duffy, J. R. Anderson, D. T. Chiu, H. Wu, O. J. A. Schueller, and G. M. Whitesides, "Review General Fabrication of microfluidic systems in poly (dimethylsiloxane), " Electrophoresis, vol.21 , pp.27-40, 2000.
13. Y. Li, W. Van Roy, L. Lagae, P. M. Vereecken, "Effects of Counter Electrode Induced Redox Cycling on Fe (III) Reduction within Microfluidic Electrochemical Cells, " J. Electrochem. Soc., vol.161, pp.E128-E134, 2014.
14. E. V. Dydek, M. V. Petersen, D. G. Nocera, K. F. Jensen, Realization of a salt bridge-free microfluidic reference electrode, Lab Chip, vol.12, pp.1431-1433, 2012.
15. M. Jamal, A. S. Sarac, E. Magner, "Conductive copolymer-modified carbon fibre microelectrodes: electrode characterization and electrochemical detection of p-aminophenol, " Sensor. Actuat. B-Chem., vol.97, pp.59-66, 2004.
16. R. Thewes, F. Hofmann, A. Frey, B. Holzapfl, M. Schienle, C. Paulus, P. Schindler, G. Eckstein, C. Kassel, M. Stanzel, R. Hintsche, E. Nebling, J. Albers, J. Hassman, J. Schülein, W. Goemann, W. Gumbrecht, "Sensor arrays for fully electronic DNA detection on CMOS", in IEEE International Solid-State Circuits Conference (ISSCC) Dig. Tech. Papers, 2002, pp. 350-351.
17. M. Sen, K. Ino, K. Y. Inoue, T. Arai, T. Nishijo, A. Suda, R. Kunikata, H. Shiku, T. Matsue, "LSI-based amperometric sensor for real-time monitoring of embryoid bodies", Biosens. Bioelectron., vol. 48, pp.12-18, 2013.
18. T. M. Squires, R. J. Messinger, S. R. Manalis, "Making it stick: convection, reaction and diffusion in surface-based biosensors", Nat. Biotechnol., vol.26, pp.417-26, 2008.
19. M. Takeda, H. Shiku, K. Ino, and T. Matsue, "Electrochemical chip integrating scalable ring-ring electrode array to detect secreted alkaline phosphatase, " Analyst, vol. 136, pp. 4991-4996, 2011.
20. B. Esteban-Fernández De Ávila, V. Escamilla-Gómez, S. Campuzano, M. Pedrero, J. P. Salvador, M. P. Marco, and J. M. Pingarrón, "Ultrasensitive amperometric magnetoimmunosensor for human C-reactive protein quantification in serum, " Sensors Actuators, B Chem., vol. 188, pp. 212-220, 2013.
21. Y. J. Yoon, K. H. H. Li, Y. Z. Low, J. Yoon, and S. H. Ng, "Microfluidics biosensor chip with integrated screen-printed electrodes for amperometric detection of nerve agent, " Sensors Actuators, B Chem., vol. 198, pp. 233-238, 2014.