Osteoblast-specific loss of IGF1R signaling results in impaired endochondral bone formation during fracture healing

Journal of Bone and Mineral Research

Volumn 30, Issue 9, 2015, Pages 1572-1584

  Wang, Tao ^a,b   Wang, Yongmei ^a   Menendez, Alicia ^a   Fong, Chak ^a   Babey, Muriel ^a   Tahimic, Candice G T ^a   Cheng, Zhiqiang ^a   Li, Alfred ^a   Chang, Wenhan ^a   Bikle, Daniel D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Civil Aviation General Hospital   (China)

Author keywords

angiogenesis; endochondral bone formation; fracture healing; IGF1 receptor; osteoblasts

Indexed keywords

ALKALINE PHOSPHATASE; COLLAGEN 10ALPHA1; COLLAGEN 1ALPHA1; COLLAGEN 2ALPHA1; COLLAGEN TYPE 1; COLLAGEN TYPE 10; COLLAGEN TYPE 2; NUCLEAR FACTOR OF ACTIVATED T CELL CYTOPLASMIC 1; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SOMATOMEDIN C RECEPTOR; TAMOXIFEN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; COLLAGEN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE MINERALIZATION; CALLUS; CARTILAGE; CARTILAGE CELL; CELL COUNT; CELL DIFFERENTIATION; CONTROLLED STUDY; CORTICAL BONE; ENCHONDRAL OSSIFICATION; FEMALE; FRACTURE HEALING; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MICRO-COMPUTED TOMOGRAPHY; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PROTEIN DEPLETION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TIBIA FRACTURE; TRABECULAR BONE; ANIMAL; BIOMECHANICS; BONE; BONE DEVELOPMENT; CYTOLOGY; GENETICS; GENOTYPE; KNOCKOUT MOUSE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TIBIA;

ANIMALS; BIOMECHANICAL PHENOMENA; BONE AND BONES; BONY CALLUS; CELL DIFFERENTIATION; COLLAGEN; FEMALE; FRACTURE HEALING; GENOTYPE; MICE; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; OSTEOBLASTS; OSTEOCLASTS; OSTEOGENESIS; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; TIBIA; TIBIAL FRACTURES; X-RAY MICROTOMOGRAPHY;

EID: 84939493896     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2510     Document Type: Article

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