Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy: Insights From Wall Shear Stress Mapping

Journal of the American College of Cardiology

Volumn 66, Issue 8, 2015, Pages 892-900

  Guzzardi, David G ^a   Barker, Alex J ^b   Van Ooij, Pim ^b,c   Malaisrie, S Chris ^b   Puthumana, Jyothy J ^b   Belke, Darrell D ^a   Mewhort, Holly E M ^a   Svystonyuk, Daniyil A ^a   Kang, Sean ^a   Verma, Subodh ^d   Collins, Jeremy ^b   Carr, James ^b   Bonow, Robert O ^b   Markl, Michael ^b,e   Thomas, James D ^b   Mccarthy, Patrick M ^b,e   Fedak, Paul W M ^a,b  

^a UNIVERSITY OF CALGARY   (Canada)

^b NORTHWESTERN UNIVERSITY   (United States)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d ST MICHAEL'S HOSPITAL   (Canada)

^e Northwestern University   (United States)

Author keywords

aneurysm; imaging; remodeling

Indexed keywords

ELASTIN; GELATINASE A; INTERSTITIAL COLLAGENASE; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE;

ADULT; AORTA DISEASE; ARTICLE; ASCENDING AORTA SURGERY; BICUSPID AORTIC VALVE; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; FLOW RATE; HEART HEMODYNAMICS; HISTOLOGY; HUMAN; MALE; MIDDLE AGED; MOLECULAR DYNAMICS; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SHEAR STRESS; AORTA; AORTA VALVE; CASE CONTROL STUDY; CONGENITAL MALFORMATION; HEMODYNAMICS; MECHANICAL STRESS; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; VALVULAR HEART DISEASE;

ADULT; AORTA; AORTIC VALVE; CASE-CONTROL STUDIES; ELASTIN; FEMALE; HEART VALVE DISEASES; HEMODYNAMICS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; STRESS, MECHANICAL; TISSUE INHIBITOR OF METALLOPROTEINASES;

EID: 84939485996     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.06.1310     Document Type: Article

References (33)

1. P.W. Fedak, S. Verma, T.E. David, and et al. Clinical and pathophysiological implications of a bicuspid aortic valve Circulation 106 2002 900 904
2. S. Verma, and S.C. Siu Aortic dilatation in patients with bicuspid aortic valve N Engl J Med 370 2014 1920 1929
3. S. Verma, B. Yanagawa, S. Kalra, and et al. Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons J Thorac Cardiovasc Surg 146 2013 1033 1040.e4
4. D. Rinewalt, P.M. McCarthy, S.C. Malaisrie, and et al. Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: Validation of contemporary guidelines J Thorac Cardiovasc Surg 148 2014 2060 2069
5. E. Girdauskas, M.A. Borger, M.A. Secknus, and et al. Is aortopathy in bicuspid aortic valve disease a congenital defect or a result of abnormal hemodynamics? A critical reappraisal of a one-sided argument Eur J Cardiothorac Surg 39 2011 809 814
6. A. Della Corte, S.C. Body, A.M. Booher, and et al. Surgical treatment of bicuspid aortic valve disease: knowledge gaps and research perspectives J Thorac Cardiovasc Surg 147 2014 1749 1757 1757.e1
7. A.J. Barker, M. Markl, J. Burk, and et al. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta Circ Cardiovasc Imaging 5 2012 457 466
8. S. Lehoux, and A. Tedgui Cellular mechanics and gene expression in blood vessels J Biomech 36 2003 631 643
9. R. Mahadevia, A.J. Barker, S. Schnell, and et al. Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy Circulation 129 2014 673 682
10. J.W. Kang, H.G. Song, D.H. Yang, and et al. Association between bicuspid aortic valve phenotype and patterns of valvular dysfunction and bicuspid aortopathy: comprehensive evaluation using MDCT and echocardiography J Am Coll Cardiol Img 6 2013 150 161
11. A. Della Corte, C. Bancone, G. Dialetto, and et al. Towards an individualized approach to bicuspid aortopathy: different valve types have unique determinants of aortic dilatation Eur J Cardiothorac Surg 45 2014 e118 e124 discussion e124
12. P. van Ooij, W.V. Potters, J. Collins, and et al. Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy Ann Biomed Eng 43 2015 1385 1397
13. R.A. Nishimura, C.M. Otto, R.O. Bonow, and et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 63 2014 e57 e185
14. M. Markl, A. Harloff, T.A. Bley, and et al. Time-resolved 3D MR velocity mapping at 3T: improved navigator-gated assessment of vascular anatomy and blood flow J Magn Reson Imaging 25 2007 824 831
15. P. van Ooij, W.V. Potters, A.J. Nederveen, and et al. A methodology to detect abnormal relative wall shear stress on the full surface of the thoracic aorta using four-dimensional flow MRI Magn Reson Med 73 2015 1216 1227
16. W.V. Potters, P. van Ooij, H. Marquering, E. van Bavel, and A.J. Nederveen Volumetric arterial wall shear stress calculation based on cine contrast MRI J Magn Reson Imaging 41 2015 505 516
17. M. Bauer, M. Pasic, R. Meyer, and et al. Morphometric analysis of aortic media in patients with bicuspid and tricuspid aortic valve Ann Thorac Surg 74 2002 58 62
18. M.M. Bissell, A.T. Hess, L. Biasiolli, and et al. Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type Circ Cardiovasc Imaging 6 2013 499 507
19. M.D. Hope, T.A. Hope, A.K. Meadows, and et al. Bicuspid aortic valve: four-dimensional MR evaluation of ascending aortic systolic flow patterns Radiology 255 2010 53 61
20. A. Forte, A. Della Corte, M. Grossi, and et al. Early cell changes and TGFbeta pathway alterations in the aortopathy associated with bicuspid aortic valve stenosis Clin Sci 124 2013 97 108
21. M. Cotrufo, A. Della Corte, L.S. De Santo, and et al. Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results J Thorac Cardiovasc Surg 130 2005 504 511
22. A. Della Corte The conundrum of aortic dissection in patients with bicuspid aortic valve: the tissue, the mechanics and the mathematics Eur J Cardiothorac Surg 48 2015 150 151
23. M. de Sa, Y. Moshkovitz, J. Butany, and T.E. David Histologic abnormalities of the ascending aorta and pulmonary trunk in patients with bicuspid aortic valve disease: clinical relevance to the Ross procedure J Thorac Cardiovasc Surg 118 1999 588 594
24. E. Girdauskas, M. Rouman, K. Disha, and et al. Correlation between systolic transvalvular flow and proximal aortic wall changes in bicuspid aortic valve stenosis Eur J Cardiothorac Surg 46 2014 234 239 discussion 239
25. M. Ohno, J.P. Cooke, V.J. Dzau, and G.H. Gibbons Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade J Clin Invest 95 1995 1363 1369
26. T.M. Holm, J.P. Habashi, J.J. Doyle, and et al. Noncanonical TGFbeta signaling contributes to aortic aneurysm progression in Marfan syndrome mice Science 332 2011 358 361
27. J.S. Ikonomidis, J.M. Ruddy, S.M. Benton Jr., and et al. Aortic dilatation with bicuspid aortic valves: cusp fusion correlates to matrix metalloproteinases and inhibitors Ann Thorac Surg 93 2012 457 463
28. A.W. Chung, K. Au Yeung, G.G. Sandor, and et al. Loss of elastic fiber integrity and reduction of vascular smooth muscle contraction resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in the thoracic aortic aneurysm in Marfan syndrome Circ Res 101 2007 512 522
29. F. Tronc, Z. Mallat, S. Lehoux, and et al. Role of matrix metalloproteinases in blood flow-induced arterial enlargement: interaction with NO Arterioscler Thromb Vasc Biol 20 2000 E120 E126
30. S.K. Atkins, K. Cao, N.M. Rajamannan, and P. Sucosky Bicuspid aortic valve hemodynamics induces abnormal medial remodeling in the convexity of porcine ascending aortas Biomech Model Mechan 13 2014 1209 1225
31. P.W. Fedak, M.P. de Sa, S. Verma, and et al. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation J Thorac Cardiovasc Surg 126 2003 797 806
32. S.W. Rabkin Differential expression of MMP-2, MMP-9 and TIMP proteins in thoracic aortic aneurysm: comparison with and without bicuspid aortic valve: a meta-analysis VASA 43 2014 433 442
33. M. Markl, W. Wallis, and A. Harloff Reproducibility of flow and wall shear stress analysis using flow-sensitive four-dimensional MRI J Magn Res Imaging 33 2011 988 994