메뉴 건너뛰기




Volumn 3, Issue 3, 2015, Pages 245-253

CD25 identifies a subset of CD4 FoxP3 TIL that are exhausted yet prognostically favorable in Human Ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3; CYTOKINE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN;

EID: 84939446621     PISSN: 23266066     EISSN: 23266074     Source Type: Journal    
DOI: 10.1158/2326-6066.CIR-14-0146     Document Type: Article
Times cited : (32)

References (50)
  • 1
    • 84858800620 scopus 로고    scopus 로고
    • The immune contexture in human tumours: Impact on clinical outcome
    • Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer 2012;12: 298-306.
    • (2012) Nat Rev Cancer , vol.12 , pp. 298-306
    • Fridman, W.H.1    Pages, F.2    Sautes-Fridman, C.3    Galon, J.4
  • 2
    • 84856021596 scopus 로고    scopus 로고
    • Prognostic significance of tumor-infiltrating T cells in ovarian cancer: A meta-analysis
    • Hwang WT, Adams SF, Tahirovic E, Hagemann IS, Coukos G. Prognostic significance of tumor-infiltrating T cells in ovarian cancer: a meta-analysis. Gynecol Oncol 2012;124:192-8.
    • (2012) Gynecol Oncol , vol.124 , pp. 192-198
    • Hwang, W.T.1    Adams, S.F.2    Tahirovic, E.3    Hagemann, I.S.4    Coukos, G.5
  • 3
    • 84885724091 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
    • Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 2013;39:782-95.
    • (2013) Immunity , vol.39 , pp. 782-795
    • Bindea, G.1    Mlecnik, B.2    Tosolini, M.3    Kirilovsky, A.4    Waldner, M.5    Obenauf, A.C.6
  • 4
    • 79959745851 scopus 로고    scopus 로고
    • The prognostic influence of tumour-infiltrating lymphocytes in cancer: A systematic review with meta-analysis
    • Gooden MJ, de Bock GH, Leffers N, Daemen T, Nijman HW. The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer 2011;105:93-103.
    • (2011) Br J Cancer , vol.105 , pp. 93-103
    • Gooden, M.J.1    De Bock, G.H.2    Leffers, N.3    Daemen, T.4    Nijman, H.W.5
  • 5
    • 84924348637 scopus 로고    scopus 로고
    • CD4 T-cell subsets and tumor immunity: The helpful and the not-so-helpful
    • Kim HJ, Cantor H. CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpful. Cancer Immunol Res 2014;2:91-8.
    • (2014) Cancer Immunol Res , vol.2 , pp. 91-98
    • Kim, H.J.1    Cantor, H.2
  • 7
    • 68149141666 scopus 로고    scopus 로고
    • Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
    • Milne K, Kobel M, Kalloger SE, Barnes RO, Gao D, Gilks CB, et al. Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS ONE 2009;4: e6412.
    • (2009) PLoS ONE , vol.4
    • Milne, K.1    Kobel, M.2    Kalloger, S.E.3    Barnes, R.O.4    Gao, D.5    Gilks, C.B.6
  • 8
    • 84893573894 scopus 로고    scopus 로고
    • The ratios of CD8+T cells to CD4+CD25+ FOXP3+ and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian cancer
    • Preston CC, Maurer MJ, Oberg AL, Visscher DW, Kalli KR, Hartmann LC, et al. The ratios of CD8+T cells to CD4+CD25+ FOXP3+ and FOXP3 - T cells correlate with poor clinical outcome in human serous ovarian cancer. PLoS One 2013;8:e80063.
    • (2013) PLoS One , vol.8
    • Preston, C.C.1    Maurer, M.J.2    Oberg, A.L.3    Visscher, D.W.4    Kalli, K.R.5    Hartmann, L.C.6
  • 9
    • 84896294304 scopus 로고    scopus 로고
    • CD4+ T effectors specific for the tumor antigen NY-ESO-1 are highly enriched at ovarian cancer sites and coexist with, but are distinct from, tumor-associated treg
    • Ayyoub M, Pignon P, Classe JM, Odunsi K, Valmori D. CD4+ T effectors specific for the tumor antigen NY-ESO-1 are highly enriched at ovarian cancer sites and coexist with, but are distinct from, tumor-associated Treg. Cancer Immunol Res 2013;1:303-8.
    • (2013) Cancer Immunol Res , vol.1 , pp. 303-308
    • Ayyoub, M.1    Pignon, P.2    Classe, J.M.3    Odunsi, K.4    Valmori, D.5
  • 10
    • 79951815749 scopus 로고    scopus 로고
    • Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer
    • Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, et al. Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res 2011;71:1263-71.
    • (2011) Cancer Res , vol.71 , pp. 1263-1271
    • Tosolini, M.1    Kirilovsky, A.2    Mlecnik, B.3    Fredriksen, T.4    Mauger, S.5    Bindea, G.6
  • 11
    • 69849107597 scopus 로고    scopus 로고
    • Phenotype, distribution, generation, and functional and clinical relevance of th17 cells in the human tumor environments
    • Kryczek I, Banerjee M, Cheng P, Vatan L, Szeliga W, Wei S, et al. Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood 2009;114:1141-9.
    • (2009) Blood , vol.114 , pp. 1141-1149
    • Kryczek, I.1    Banerjee, M.2    Cheng, P.3    Vatan, L.4    Szeliga, W.5    Wei, S.6
  • 12
    • 79952465385 scopus 로고    scopus 로고
    • Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients
    • Chen JG, Xia JC, Liang XT, Pan K, Wang W, Lv L, et al. Intratumoral expression of IL-17 and its prognostic role in gastric adenocarcinoma patients. Int J Biol Sci 2011;7:53-60.
    • (2011) Int J Biol Sci , vol.7 , pp. 53-60
    • Chen, J.G.1    Xia, J.C.2    Liang, X.T.3    Pan, K.4    Wang, W.5    Lv, L.6
  • 13
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol 2012;30:531-64.
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 14
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004;10:942-9.
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 15
    • 29444442811 scopus 로고    scopus 로고
    • Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    • Sato E, Olson SH, Ahn J, Bundy B, Nishikawa H, Qian F, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. Proc Natl Acad Sci USA 2005;102:18538-43.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18538-18543
    • Sato, E.1    Olson, S.H.2    Ahn, J.3    Bundy, B.4    Nishikawa, H.5    Qian, F.6
  • 16
    • 42749092358 scopus 로고    scopus 로고
    • Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: Association with p53 mutations, circulating tumor DNA and survival in women with ovarian cancer
    • Shah CA, Allison KH, Garcia RL, Gray HJ, Goff BA, Swisher EM. Intratumoral T cells, tumor-associated macrophages, and regulatory T cells: association with p53 mutations, circulating tumor DNA and survival in women with ovarian cancer. Gynecol Oncol 2008;109:215-9.
    • (2008) Gynecol Oncol , vol.109 , pp. 215-219
    • Shah, C.A.1    Allison, K.H.2    Garcia, R.L.3    Gray, H.J.4    Goff, B.A.5    Swisher, E.M.6
  • 17
    • 84861783871 scopus 로고    scopus 로고
    • The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: A critical review of the literature
    • deLeeuw RJ, Kost SE, Kakal JA, Nelson BH. The prognostic value of FoxP3+ tumor-infiltrating lymphocytes in cancer: a critical review of the literature. Clin Cancer Res 2012;18:3022-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 3022-3029
    • DeLeeuw, R.J.1    Kost, S.E.2    Kakal, J.A.3    Nelson, B.H.4
  • 18
    • 77955890953 scopus 로고    scopus 로고
    • Interleukin-2 receptor signaling: At the interface between tolerance and immunity
    • Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity 2010;33:153-65.
    • (2010) Immunity , vol.33 , pp. 153-165
    • Malek, T.R.1    Castro, I.2
  • 19
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 2005;115:3623-33.
    • (2005) J Clin Invest , vol.115 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3    Yang, B.K.4    Coleman, D.5    Yancey, D.6
  • 20
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigenspecific immune responses to cancer vaccines
    • Morse MA, Hobeika AC, Osada T, Serra D, Niedzwiecki D, Lyerly HK, et al. Depletion of human regulatory T cells specifically enhances antigenspecific immune responses to cancer vaccines. Blood 2008;112:610-8.
    • (2008) Blood , vol.112 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6
  • 21
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells
    • Rech AJ, Vonderheide RH. Clinical use of anti-CD25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory T cells. Ann N Y Acad Sci 2009;1174:99-106.
    • (2009) Ann N y Acad Sci , vol.1174 , pp. 99-106
    • Rech, A.J.1    Von Der Heide, R.H.2
  • 22
    • 84892702492 scopus 로고    scopus 로고
    • The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis
    • Milo R. The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis. Ther Adv Neurol Disord 2014;7:7-21.
    • (2014) Ther Adv Neurol Disord , vol.7 , pp. 7-21
    • Milo, R.1
  • 23
    • 0036604208 scopus 로고    scopus 로고
    • Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses
    • D'Souza WN, Schluns KS, Masopust D, Lefrancois L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol 2002;168:5566-72.
    • (2002) J Immunol , vol.168 , pp. 5566-5572
    • D'Souza, W.N.1    Schluns, K.S.2    Masopust, D.3    Lefrancois, L.4
  • 24
    • 0345447666 scopus 로고    scopus 로고
    • IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
    • D'Souza WN, Lefrancois L. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol 2003;171:5727-35.
    • (2003) J Immunol , vol.171 , pp. 5727-5735
    • D'Souza, W.N.1    Lefrancois, L.2
  • 25
    • 37249046879 scopus 로고    scopus 로고
    • CD8+ T cells induce complete regression of advanced ovarian cancers by an interleukin (IL)-2/IL-15 dependent mechanism
    • Yang T, Wall EM, Milne K, Theiss P, Watson P, Nelson BH. CD8+ T cells induce complete regression of advanced ovarian cancers by an Interleukin (IL)-2/IL-15 dependent mechanism. Clin Cancer Res 2007;13:7172-80.
    • (2007) Clin Cancer Res , vol.13 , pp. 7172-7180
    • Yang, T.1    Wall, E.M.2    Milne, K.3    Theiss, P.4    Watson, P.5    Nelson, B.H.6
  • 26
    • 84902191817 scopus 로고    scopus 로고
    • IL-2: The first effective immunotherapy for human cancer
    • Rosenberg SA IL-2: the first effective immunotherapy for human cancer. J Immunol 2014;192:5451-8.
    • (2014) J Immunol , vol.192 , pp. 5451-5458
    • Rosenberg, S.A.1
  • 27
    • 9844256432 scopus 로고    scopus 로고
    • Comparison of toxicity and survival following intraperitoneal recombinant interleukin-2 for persistent ovarian cancer after platinum: Twenty-four-hour versus 7-day infusion
    • Edwards RP, Gooding W, Lembersky BC, Colonello K, Hammond R, Paradise C, et al. Comparison of toxicity and survival following intraperitoneal recombinant interleukin-2 for persistent ovarian cancer after platinum: twenty-four-hour versus 7-day infusion. J Clin Oncol 1997;15:3399-407.
    • (1997) J Clin Oncol , vol.15 , pp. 3399-3407
    • Edwards, R.P.1    Gooding, W.2    Lembersky, B.C.3    Colonello, K.4    Hammond, R.5    Paradise, C.6
  • 28
    • 71849090003 scopus 로고    scopus 로고
    • A phase II trial of intraperitoneal interleukin-2 in patients with platinumresistant or platinum-refractory ovarian cancer
    • Vlad AM, Budiu RA, Lenzner DE, Wang Y, Thaller JA, Colonello K, et al. A phase II trial of intraperitoneal interleukin-2 in patients with platinumresistant or platinum-refractory ovarian cancer. Cancer Immunol Immun other 2009;59:293-301.
    • (2009) Cancer Immunol Immun Other , vol.59 , pp. 293-301
    • Vlad, A.M.1    Budiu, R.A.2    Lenzner, D.E.3    Wang, Y.4    Thaller, J.A.5    Colonello, K.6
  • 29
    • 61349151645 scopus 로고    scopus 로고
    • Intraepithelial T cells and prognosis in ovarian carcinoma: Novel associations with stage, tumor type, and BRCA1 loss
    • Clarke B, Tinker AV, Lee CH, Subramanian S, van de Rijn M, Turbin D, et al. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. Mod Pathol 2009;22:393-402.
    • (2009) Mod Pathol , vol.22 , pp. 393-402
    • Clarke, B.1    Tinker, A.V.2    Lee, C.H.3    Subramanian, S.4    Van De Rijn, M.5    Turbin, D.6
  • 30
    • 84872608638 scopus 로고    scopus 로고
    • Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptornegative breast cancer
    • West NR, Kost SE, Martin SD, Milne K, Deleeuw RJ, Nelson BH, et al. Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptornegative breast cancer. Br J Cancer 2012;108:155-62.
    • (2012) Br J Cancer , vol.108 , pp. 155-162
    • West, N.R.1    Kost, S.E.2    Martin, S.D.3    Milne, K.4    Deleeuw, R.J.5    Nelson, B.H.6
  • 31
    • 67649216549 scopus 로고    scopus 로고
    • Antibody elution method for multiple immunohistochemistry on primary antibodies raised in the same species and of the same subtype
    • Pirici D, Mogoanta L, Kumar-Singh S, Pirici I, Margaritescu C, Simionescu C, et al. Antibody elution method for multiple immunohistochemistry on primary antibodies raised in the same species and of the same subtype. J Histochem Cytochem 2009;57:567-75.
    • (2009) J Histochem Cytochem , vol.57 , pp. 567-575
    • Pirici, D.1    Mogoanta, L.2    Kumar-Singh, S.3    Pirici, I.4    Margaritescu, C.5    Simionescu, C.6
  • 32
    • 33745813929 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells
    • Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 2006;203:1693-700.
    • (2006) J Exp Med , vol.203 , pp. 1693-1700
    • Seddiki, N.1    Santner-Nanan, B.2    Martinson, J.3    Zaunders, J.4    Sasson, S.5    Landay, A.6
  • 33
    • 84900301377 scopus 로고    scopus 로고
    • Cancer immunotherapy basedonmutation-specific CD4+ tcellsin apatient with epithelial cancer
    • Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, et al. Cancer immunotherapy basedonmutation-specific CD4+ Tcellsin apatient with epithelial cancer. Science 2014;344:641-5.
    • (2014) Science , vol.344 , pp. 641-645
    • Tran, E.1    Turcotte, S.2    Gros, A.3    Robbins, P.F.4    Lu, Y.C.5    Dudley, M.E.6
  • 34
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood 2009;114:1537-44.
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6
  • 35
    • 84899748384 scopus 로고    scopus 로고
    • PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors
    • Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, et al. PD-1 identifies the patient-specific CD8(+) tumor-reactive repertoire infiltrating human tumors. J Clin Invest 2014;124:2246-59.
    • (2014) J Clin Invest , vol.124 , pp. 2246-2259
    • Gros, A.1    Robbins, P.F.2    Yao, X.3    Li, Y.F.4    Turcotte, S.5    Tran, E.6
  • 37
    • 65949111746 scopus 로고    scopus 로고
    • FOXP3 defines regulatory T cells in human tumor and autoimmune disease
    • Kryczek I, Liu R, Wang G, Wu K, Shu X, Szeliga W, et al. FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Res 2009;69:3995-4000.
    • (2009) Cancer Res , vol.69 , pp. 3995-4000
    • Kryczek, I.1    Liu, R.2    Wang, G.3    Wu, K.4    Shu, X.5    Szeliga, W.6
  • 38
    • 63649120341 scopus 로고    scopus 로고
    • Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells
    • Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, et al. Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells. J Immunother 2009;32:101-8.
    • (2009) J Immunother , vol.32 , pp. 101-108
    • Leveque, L.1    Deknuydt, F.2    Bioley, G.3    Old, L.J.4    Matsuzaki, J.5    Odunsi, K.6
  • 41
    • 84872872011 scopus 로고    scopus 로고
    • Dynamics of T-cell infiltration during the course of ovarian cancer: The gradual shift from a th17 effector cell response to a predominant infiltration by regulatory T-cells
    • Fialova A, Partlova S, Sojka L, Hromadkova H, Brtnicky T, Fucikova J, et al. Dynamics of T-cell infiltration during the course of ovarian cancer: the gradual shift from a Th17 effector cell response to a predominant infiltration by regulatory T-cells. Int J Cancer 2012;132:1070-9.
    • (2012) Int J Cancer , vol.132 , pp. 1070-1079
    • Fialova, A.1    Partlova, S.2    Sojka, L.3    Hromadkova, H.4    Brtnicky, T.5    Fucikova, J.6
  • 42
    • 79960905304 scopus 로고    scopus 로고
    • NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ treg compartment
    • Redjimi N, Duperrier-Amouriaux K, Raimbaud I, Luescher I, Dojcinovic D, Classe JM, et al. NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment. PLoS One 2011;6:e22845.
    • (2011) PLoS One , vol.6
    • Redjimi, N.1    Duperrier-Amouriaux, K.2    Raimbaud, I.3    Luescher, I.4    Dojcinovic, D.5    Classe, J.M.6
  • 43
    • 84907190276 scopus 로고    scopus 로고
    • Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction
    • Kurktschiev PD, Raziorrouh B, Schraut W, Backmund M, Wachtler M, Wendtner CM, et al. Dysfunctional CD8+ T cells in hepatitis B and C are characterized by a lack of antigen-specific T-bet induction. J Exp Med 2014;211:2047-59.
    • (2014) J Exp Med , vol.211 , pp. 2047-2059
    • Kurktschiev, P.D.1    Raziorrouh, B.2    Schraut, W.3    Backmund, M.4    Wachtler, M.5    Wendtner, C.M.6
  • 44
    • 84872790689 scopus 로고    scopus 로고
    • Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
    • Liao W, Lin JX, Leonard WJ. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity 2013;38:13-25.
    • (2013) Immunity , vol.38 , pp. 13-25
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 45
    • 84962284148 scopus 로고    scopus 로고
    • TGF-b1 enhances T-cell PD-1 expression through a smad3-dependant increase in transcription. (IRM4P.499)
    • Park B, Chattergoon M, Pan F, Pardoll D, Cox A. TGF-b1 enhances T-cell PD-1 expression through a Smad3-dependant increase in transcription. (IRM4P.499). J Immunol 2014. p. 1 Supplement-61.6.
    • (2014) J Immunol , pp. 1
    • Park, B.1    Chattergoon, M.2    Pan, F.3    Pardoll, D.4    Cox, A.5
  • 46
    • 84887862839 scopus 로고    scopus 로고
    • A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
    • Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol 2013;14:1212-8.
    • (2013) Nat Immunol , vol.14 , pp. 1212-1218
    • Okazaki, T.1    Chikuma, S.2    Iwai, Y.3    Fagarasan, S.4    Honjo, T.5
  • 47
    • 84879703551 scopus 로고    scopus 로고
    • Strength of PD-1 signaling differentially affects T-cell effector functions
    • Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, et al. Strength of PD-1 signaling differentially affects T-cell effector functions. Proc Natl Acad Sci U S A 2013;110:E2480-9.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. E2480-E2489
    • Wei, F.1    Zhong, S.2    Ma, Z.3    Kong, H.4    Medvec, A.5    Ahmed, R.6
  • 48
    • 84884271914 scopus 로고    scopus 로고
    • Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma
    • Simpson TR, Li F, Montalvo-Ortiz W, Sepulveda MA, Bergerhoff K, Arce F, et al. Fc-dependent depletion of tumor-infiltrating regulatory T cells codefines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med 2013;210:1695-710.
    • (2013) J Exp Med , vol.210 , pp. 1695-1710
    • Simpson, T.R.1    Li, F.2    Montalvo-Ortiz, W.3    Sepulveda, M.A.4    Bergerhoff, K.5    Arce, F.6
  • 50
    • 14744285671 scopus 로고    scopus 로고
    • Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: A novel regulatory role for OX40 and its comparison with GITR
    • Valzasina B, Guiducci C, Dislich H, Killeen N, Weinberg AD, Colombo MP. Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood 2005;105:2845-51.
    • (2005) Blood , vol.105 , pp. 2845-2851
    • Valzasina, B.1    Guiducci, C.2    Dislich, H.3    Killeen, N.4    Weinberg, A.D.5    Colombo, M.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.