Normalization of T2 relaxation time and apparent diffusion coefficient in relation to the inflammatory changes in the substantia nigra of rats with focal cerebral ischemia

Acta Radiologica

Volumn 56, Issue 7, 2015, Pages 837-843

  Yang, Yan Mei ^a   Li, Chan Chan ^a   Yin, Le Kang ^a   Feng, Xiao Yuan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Immunohistochemistry; Inflammation; Magnetic resonance imaging (MRI); Substantia nigra

Indexed keywords

BLOOD VESSELS; CHEMICAL ACTIVATION; COMPUTERIZED TOMOGRAPHY; DIFFUSION; MAGNETIC RESONANCE IMAGING; RATS; RELAXATION TIME; SURFACE DIFFUSION;

APPARENT DIFFUSION COEFFICIENT; CEREBRAL ISCHEMIA; FOCAL CEREBRAL ISCHEMIAS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MIDDLE CEREBRAL ARTERY OCCLUSIONS; PATHOPHYSIOLOGICAL CHANGES; SUBSTANTIA NIGRA;

BRAIN;

ANIMAL; BRAIN ISCHEMIA; COMPLICATION; ENCEPHALITIS; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT; SUBSTANTIA NIGRA;

ANIMALS; BRAIN ISCHEMIA; ENCEPHALITIS; MAGNETIC RESONANCE IMAGING; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 84939440058     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.1177/0284185114549496     Document Type: Article

References (16)

1. Block F, Dihne M, Loos M. Inflammation in areas of remote changes following focal brain lesion. Prog Neurobiol 2005;75:342-365.
2. Uchida H, Yokoyama H, Kimoto H, et al. Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. Int J Exp Path 2010;91: 256-266.
3. Rodriguez-Grande B, Blackabey V, Gittens B, et al. Loss of substance P and inflammation precede delayed neurodegeneration in the substantia nigra after cerebral ischemia. Brain Behav Immun 2013;29:51-61.
4. Leiva-Salinas C, Wintermark M, Kidwell CS. Neuroimaging of cerebral ischemia and infarction. Neurotherapeutics 2011;8:19-27.
5. Yang YM, Feng XY, Yin le K, et al. In vivo USPIO-enhanced MR signal characteristics of secondary degeneration in the ipsilateral substantia nigra after middle cerebral artery occlusion at 3T. J Neuroradiol 2013;40: 198-203.
6. Brecht S, Waetzig V, Hidding U, et al. FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. Anat Rec (Hoboken) 2009;292:1993-2001.
7. Bihel E, Pro-Sistiaga P, Letourneur A, et al. Permanent or transient chronic ischemic stroke in the non-human primate: behavioral, neuroimaging, histological, and immunohistochemical investigations. J Cereb Blood Flow Metab 2010;30:273-285.
8. Nakane M, Tamura A, Miyasaka N, et al. Astrocytic swelling in the ipsilateral substantia nigra after occlusion of the middle cerebral artery in rats. Am J Neuroradiol 2001;22:660-663.
9. Yang YM, Feng XY, Yao ZW, et al. Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner. J Neurosci Meth 2008;167: 176-183.
10. Zhao F, Kuroiwa T, Miyasaka N, et al. Characteristic changes in T(2)-value, apparent diffusion coefficient, and ultrastructure of substantia nigra evolving exofocal postischemic neuronal death in rats. Brain Res 2001;895: 238-244.
11. Nakane M, Tamura A, Nagaoka T, et al. MR detection of secondary changes remote from ischemia: preliminary observations after occlusion of the middle cerebral artery in rats. Am J Neuroradiol 1997;18:945-950.
12. Abe O, Nakane M, Aoki S, et al. MR imaging of post-ischemic neuronal death in the substantia nigra and thalamus following middle cerebral artery occlusion in rats. NMR Biomed 2003;16:152-159.
13. Schroeter M, Franke C, Stoll G, et al. Dynamic changes of MRI abnormalities in relation to inflammation and glial responses after photothrombotic cerebral infarction in the rat brain. Acta Neuropathol 2001;101:114-122.
14. Wagner DC, Deten A, Hartig W, et al. Changes in T2 relaxation time after stroke reflect clearing processes. NeuroImage 2012;61:780-785.
15. Wegener S, Weber R, Ramos-Cabrer P, et al. Temporal profile of T2-weighted MRI distinguishes between pannecrosis and selective neuronal death after transient focal cerebral ischemia in the rat. J Cereb Blood Flow Metab 2006;26:38-47.
16. Weber R, Wegener S, Ramos-Cabrer P, et al. MRI detection of macrophage activity after experimental stroke in rats: new indicators for late appearance of vascular degradation? Magn Reson Med 2005;54:59-66.