In vivo USPIO-enhanced MR signal characteristics of secondary degeneration in the ipsilateral substantia nigra after middle cerebral artery occlusion at 3T

Journal of Neuroradiology

Volumn 40, Issue 3, 2013, Pages 198-203

  Yang, Yan Mei ^a   Feng, Xiao Yuan ^a   Yin, Le Kang ^a   Li, Chan Chan ^a   Li, An Ning ^a   Jia, Jie ^a   Wang, Xiao Lou ^a   Du, Zun Guo ^a   Jin, Li Xin ^b  

^a FUDAN UNIVERSITY   (China)

^b SIEMENS LTD   (China)

Author keywords

Focal cerebral ischemia; MRI; Secondary degeneration; Substantia nigra; USPIO

Indexed keywords

FERRIC FERROCYANIDE; GADOLINIUM PENTETATE; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DEGENERATION; BRAIN ISCHEMIA; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE ASSOCIATION; HISTOPATHOLOGY; IMAGE ANALYSIS; IMAGE DISPLAY; IMAGE PROCESSING; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SUBSTANTIA NIGRA;

BBB; BLOOD-BRAIN BARRIER; FOCAL CEREBRAL ISCHEMIA; H&E; HEMATOXYLIN AND EOSIN; MCAO; MIDDLE CEREBRAL ARTERY OCCLUSION; MRI; PB; PRUSSIAN BLUE; REGION OF INTEREST; ROI; SD; SECONDARY DEGENERATION; SN; ST; STANDARD DEVIATION; STRIATUM; SUBSTANTIA NIGRA; T1-WEIGHTED IMAGING; T1WI; T2-WEIGHTED IMAGING; T2WI; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; USPIO;

ANIMALS; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANTIA NIGRA;

EID: 84880036743     PISSN: 01509861     EISSN: 17730406     Source Type: Journal    
DOI: 10.1016/j.neurad.2012.11.002     Document Type: Article

References (24)

1. Nakane M., Tamura A., Miyasaka N., et al. Astrocytic swelling in the ipsilateral substantia nigra after occlusion of the middle cerebral artery in rats. AJNR Am J Neuroradiol 2001, 22:660-663.
2. Zhao F., Kuroiwa T., Miyasaka N., et al. Characteristic changes in T(2)-value, apparent diffusion coefficient, and ultrastructure of substantia nigra evolving exofocal postischemic neuronal death in rats. Brain Res 2001, 895:238-244.
3. Nakane M., Tamura A., Nagaoka T., et al. MR detection of secondary changes remote from ischemia: preliminary observations after occlusion of the middle cerebral artery in rats. AJNR Am J Neuroradiol 1997, 18:945-950.
4. Abe O., Nakane M., Aoki S., et al. MR imaging of post-ischemic neuronal death in the substantia nigra and thalamus following middle cerebral artery occlusion in rats. NMR Biomed 2003, 16:152-159.
5. Ogawa T., Okudera T., Inugami A., et al. Degeneration of the ipsilateral substantia nigra after striatal infarction: evaluation with MR imaging. Radiology 1997, 204:847-851.
6. Nakane M., Teraoka A., Asato R., et al. Degeneration of the ipsilateral substantia nigra following cerebral infarction in the striatum. Stroke 1992, 23:328-332.
7. Dihne M., Block F. Focal ischemia induces transient expression of IL-6 in the substantia nigra pars reticulata. Brain Res 2001, 889:165-173.
8. Loos M., Dihne M., Block F. Tumor necrosis factor-expression in areas of remote degeneration following middle cerebral artery occlusion of the rat. Neuroscience 2003, 122:373-380.
9. Huh Y., Jung J.W., Park C., et al. Microglial activation and tyrosine hydroxylase immunoreactivity in the substantia nigral region following transient focal ischemia in rats. Neurosci Lett 2003, 349:63-67.
10. Saleh A., Wiedermann D., Schroeter M., et al. Central nervous system inflammatory response after cerebral infarction as detected by magnetic resonance imaging. NMR Biomed 2004, 17:163-169.
11. Farr T.D., Seehafer J.U., Nelles M., et al. Challenges towards MR imaging of the peripheral inflammatory response in the subacute and chronic stages of transient focal ischemia. NMR Biomed 2011, 24:35-45.
12. Desestret V., Brisset J.C., Moucharrafie S., et al. Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice. Stroke 2009, 40:1834-1841.
13. Wiart M., Davoust N., Pialat J.B., et al. MRI monitoring of neuroinflammation in mouse focal ischemia. Stroke 2007, 38:131-137.
14. Denes A., Vidyasagar R., Feng J., et al. Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab 2007, 27:1941-1953.
15. Kleinschnitz C., Bendszus M., Frank M., et al. In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging. J Cereb Blood Flow Metab 2003, 23:1356-1361.
16. Saleh A., Schroeter M., Ringelstein A., et al. Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke. Stroke 2007, 38:2733-2737.
17. Nighoghossian N., Wiart M., Cakmak S., et al. Inflammatory response after ischemic stroke - a USPIO-Enhanced MRI study in patients. Stroke 2007, 38:303-307.
18. Yang Y.M., Feng X., Yao Z.W., et al. Magnetic resonance angiography of carotid and cerebral arterial occlusion in rats using a clinical scanner. J Neurosci Methods 2008, 167:176-183.
19. Zhang Z., Dharmakumar R., Mascheri N., et al. Comparison of superparamagnetic and ultrasmall superparamagnetic iron oxide cell labelling for tracking green fluorescent protein gene marker with negative and positive contrast magnetic resonance imaging. Mol Imaging 2009, 8:148-155.
20. Schilling M., Besselmann M., Muller M., et al. Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol 2005, 196:290-297.
21. Kleinschnitz C., Schutz A., Nolte I., et al. In vivo detectation of developing vessel occlusion in photothrombotic ischemic brain lesions in the rat by iron particle enhanced MRI. J Cereb Blood Flow Metab 2005, 25:1548-1555.
22. Stroh A., Zimmer C., Werner N., et al. Tracking of systematically administrated mononuclear cells in the ischemic brain by high-field magnetic resonance imaging. Neuroimage 2006, 33:886-897.
23. Uchida H., Yokoyama H., Kimoto H., et al. Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. Int J Exp Pathol 2010, 91:256-266.
24. Brecht S., Waetzig V., Hidding U., et al. FK506 protects against various immune responses and secondary degeneration following cerebral ischemia. Anat Rec (Hoboken) 2009, 292:1993-2001.