Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis

Applied Radiation and Isotopes

Volumn 105, Issue , 2015, Pages 66-71

  Coliva, A ^a   Monterisi, C ^b   Apollaro, A ^b   Gatti, D ^c   Penso, M ^b   Gianolli, L ^c   Perani, D ^a,b   Gilardi, M C ^b,c   Carpinelli, A ^b,c  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b CNR   (Italy)

^c SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Alzheimer's disease; Cyclotron; 11C MeOTf; 11C PIB; amyloid

Indexed keywords

ALKYLATION; CYCLOTRONS; DIAGNOSIS; GLYCOPROTEINS;

ALZHEIMER'S DISEASE; INITIAL CONCENTRATION; PURIFICATION METHOD; RADIOCHEMICAL YIELD; SPECIFIC ACTIVITY; SYNTHESIS OPTIMIZATION; [11C]MEOTF; [11C]PIB;

NEURODEGENERATIVE DISEASES;

2 BUTANONE; ACETONITRILE; ALCOHOL; CARBON 2 (4 N METHYLAMINOPHENYL) 6 HYDROXYBENZOTHIAZOLE C 11; CARBON METHYL TRIFLATE C 11; CITRIC ACID; SOLVENT; TRACER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; BENZOTHIAZOLE DERIVATIVE; CARBON; N-METHYL-2-(4'-METHYLAMINOPHENYL)-6-HYDROXYBENZOTHIAZOLE; RADIOPHARMACEUTICAL AGENT;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG FORMULATION; DRUG HALF LIFE; DRUG PURIFICATION; DRUG PURITY; DRUG SPECIFICITY; DRUG SYNTHESIS; FEASIBILITY STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; PHARMACOLOGICAL PARAMETERS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RADIOCHEMICAL PURITY; RADIOCHEMICAL YIELD; VALIDATION STUDY; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; PROCEDURES; QUALITY CONTROL; SCINTISCANNING; STANDARDS; SYNTHESIS;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BENZOTHIAZOLES; CARBON RADIOISOTOPES; HUMANS; POSITRON-EMISSION TOMOGRAPHY; QUALITY CONTROL; RADIOPHARMACEUTICALS;

EID: 84939429333     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2015.07.003     Document Type: Article

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