Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats

Phytomedicine

Volumn 22, Issue 10, 2015, Pages 952-960

  Lekshmi, R K ^a   Rajesh, R ^a   Mini, S ^a  

^a UNIVERSITY OF KERALA   (India)

Author keywords

Antioxidants; Diabetes mellitus; Inflammation; Oxidative stress; Quercetin

Indexed keywords

2,4 BIS(1,1 DIMETHYLETHYL); ACETIC ACID ETHYL ESTER; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ARACHIDONATE 5 LIPOXYGENASE; ASPARTATE AMINOTRANSFERASE; CATALASE; CISSUS QUADRANGULARIS EXTRACT; CYCLOOXYGENASE 2; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEMOGLOBIN A1C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INTERLEUKIN 6; MESSENGER RNA; METFORMIN; NICOTINAMIDE; PHENOL; QUERCETIN; STREPTOZOCIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTIOXIDANT; CYTOKINE; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CISSUS QUADRANGULARIS; CONTROLLED STUDY; DIABETOGENESIS; DRUG IDENTIFICATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIPID PEROXIDATION; LIVER; MALE; MASS FRAGMENTOGRAPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PLANT STEM; PRIORITY JOURNAL; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BLOOD; CHEMISTRY; CISSUS; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; ENZYMOLOGY; INFLAMMATION; MEDICINAL PLANT; METABOLISM; OXIDATIVE STRESS; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

CISSUS QUADRANGULARIS; RATTUS;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CISSUS; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; HEMOGLOBIN A, GLYCOSYLATED; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INFLAMMATION; INSULIN; LIPID PEROXIDATION; LIVER; MALE; NIACINAMIDE; OXIDATIVE STRESS; PLANT STEMS; PLANTS, MEDICINAL; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

EID: 84939424558     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.06.014     Document Type: Article

References (31)

1. Ambavaram M.R., Vaka S.R., Brian E.S., Udo W., Arjula R.R. Novel transgenic rice over expressing anthocyanidin synthase accumulates a mixture of flavonoids leading to an increased antioxidant potential Metab. Eng. 9 2007 95 111
2. Axelrod B., Cheesbrough T.M., Laakso S. Lipoxygenases from soybeans Methods Enzymol. 71 1981 441 451
3. Bancroft G.D., Stevens A., Turner D.R. Theory and Practice of Technique 4th edition 1996 Churchill Livingston New York
4. Bhagath K.P., Muddanna, S.R. Gopalan, K.N. Mallikarjuna, R.K. Chamallamudi, Keerthana P., Soubhagya R.N., Praveen K.D., Vivekananda K., Kumar M.R.B. Evidence-based assessment of antiosteoporotic activity of petroleum-ether extract of Cissus quadrangularis Linn. on ovariectomy-induced osteoporosis Ups. J. Med. Sci 114 2009 140 148
5. Chomcynski P., Sacchi N. Single-step method of RNA isolation by acid guanidiniumthiocyanate-phenolchloroform extraction Anal. Biochem. 162 1995 156 159
6. David M., Richard J.S. Glutathione reductase Bermeyer Hans Ulrich. Methods of Enzymatic Analysis 1983 Academic Press New York, USA 258 265
7. Donath M.Y. Targeting inflammation in the treatment of type 2 diabetes Diabetes, Obes. Metab. 15 2013 193 196
8. Engval E., Perlman P. Enzyme-linked immunosorbent assay (ELISA) Quantitative assay of immunoglobulin G. Immunochemistry. 8 1971 871 874
9. Fernandes G., Banu J. Medicinal properties of plants from the genus Cissus: a review J. Med. Plant Res. 6 2012 3080 3086
10. Goldin A., Beckman J.A., Schmidt A.M., Creager M.A. Advanced glycation end products: sparking the development of diabetic vascular injury Circulation. 114 2006 597 605
11. Gratas-Delamarche A., Derbrie F., Vincent S., Cillard J. Physical inactivity, insulin resistance, and the oxidative inflammatory loop Free Radic. Res. 48 2014 93 108
12. Huch H.Y., Pearce S.F., Tersner J.M., Schindler I.L., Silverstein R.L. Regulated expression of CD36 in foam cell formation Blood. 87 1996 2020 2025
13. Jain S.K., Kannan K., Lim G., Matthew-Greer J., McVie R., Bocchini J.A. Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes Diabetes Care. 26 2003 2139 2143
14. Kakkar P., Dos B., Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase Indian J. Biochem. Biophys. 21 1984 130 132
15. Lekshmi R.K., Divya B.T., Mini S. Cissus quadrangularis extract attenuates hyperglycaemia-mediated oxidative stress in streptozotocin-induced diabetic rats Redox Report 19 2014 214 220
16. Lekshmi R.K., Mini S. Evaluation of antioxidant and antiglycation activities of various solvent fractions of Cissus quadrangularis stem Int. J. Pharm. Biosci. 4 2013 1259 1268
17. Lekshmi R.K., Sreekutty M.S., Mini S. The regulatory effects of Cissus quadrangularis on some enzymes involved in carbohydrate metabolism in Streptozotocin induced diabetic rats Pharm. Biol. 53 4 2015 1 7
18. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
19. Madar Z., Kalet L.S., Stark A.H. Inducible nitric oxide synthase activity and expression in liver and hepatocytes of diabetic rats Pharmacology. 73 2004 106 112
20. Maehly A.C., Chance B. The assay of catalases and peroxidises Glick D. Methods of Biochemical Analysis 1 1954 Interscience 357 424
21. Masiello P., Broca C., Gross R., Roye M., Manteghetti M., Hillaire-Buys D., Novelli M., Ribes G. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide Diabetes. 47 1998 224 229
22. Navarro C.M., Montilla P.M., Martin A. Free radicals scavenger and antihepatotoxic activity of Rosmarinus Planta Med 59 1993 312 314
23. Navarro-Gonzalez J.F., Mora-Fernandez C. The role of inflammatory cytokines in diabetic nephropathy J. Am. Soc. Nephrol. 19 2008 433 442
24. Oben J.E., Ngondi J.L., Momo C.N., Agbor G.A., Sobgui C.S.M. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double blind placebo-controlled study Lipids Health Dis. 7 2008 12
25. Okhawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric reaction Anal. Biochem. 95 1979 351 358
26. Patterson J.W., Lazarow A. Determination of glutathione Glick D. Methods of Biochemical Analysis 1955 Inter Science New York 259
27. Rotruck J.T., Pope A.L., Ganther H.E. Selenium: biochemical roles as a component of glutathione peroxidase Science. 179 1973 588 590
28. Shanmugam N., Todorov I.T., Nair I., Omori K., Reddy M.A., Natarajan R. Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER), and in islets from diabetic mice Diabetologia. 49 2006 100 107
29. Shil C.K., Prasad S., Suresh B.V., Kesavan P.K., Swapna G., Ravikumar J., Suhasini K., Ravindra K.C., Madhu G.S. Safety assessment of Cissus quadrangularis extracts (CQR-300): subchronic toxicity and mutagenicity studies Food Chem. Toxicol. 49 2011 3343 3357
30. Shimazu T., Kondo K., Hayaishi O. Role of prostaglandin endoperoxides in the serum thiobarbituric acid reaction Arch. Biochem. Biophys. 206 1981 271 276
31. Sunil C., Duraipandiyan V., Agastian P., Ignacimuthu S. Antidiabetic effect of plumbagin isolated from Plumbago zeylanica L. root and its effect on GLUT4 translocation in streptozotocin-induced diabetic rats Food Chem. Toxicol. 50 2012 4356 4363