Hydrodynamic Effects on Drug Dissolution and Deaggregation in the Small Intestine - A Study with Felodipine as a Model Drug

Journal of Pharmaceutical Sciences

Volumn 104, Issue 9, 2015, Pages 2969-2976

  Lindfors, Lennart ^a   Jonsson, Malin ^a   Weibull, Emelie ^a   Brasseur, James G ^b   Abrahamsson, Bertil ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b The Pennsylvania State University   (United States)

Author keywords

ab initio calculations; de aggregation; dissolution; felodipine; Fick's first law; gastrointestinal; in silico modeling; in vitro models; particle sizing

Indexed keywords

FELODIPINE; SURFACTANT; SUSPENSION;

AB INITIO CALCULATION; ARTICLE; CALCULATION; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CRITICAL MICELLE CONCENTRATION; DEAGGREGATION; DISSOLUTION; DRUG SOLUBILITY; HYDRODYNAMICS; IN VIVO STUDY; PARTICLE SIZE; PHARMACOLOGICAL PARAMETERS; SHEAR STRESS; SMALL INTESTINE; SURFACE TENSION; ZETA POTENTIAL; ANIMAL; CHEMISTRY; COMPUTER SIMULATION; DRUG RELEASE; INTESTINE ABSORPTION; MEDICINAL CHEMISTRY; METABOLISM; PHARMACOKINETICS; PHYSIOLOGY; PROCEDURES; RAT; SOLUBILITY; SUSPENSION; THEORETICAL MODEL;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; COMPUTER SIMULATION; DRUG LIBERATION; FELODIPINE; HYDRODYNAMICS; INTESTINAL ABSORPTION; INTESTINE, SMALL; MODELS, THEORETICAL; RATS; SOLUBILITY; SURFACE-ACTIVE AGENTS; SUSPENSIONS;

EID: 84939270639     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24487     Document Type: Article

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