Efficient synthesis of the intermediate of abacavir and carbovir using a novel (+)-γ-lactamase as a catalyst

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 18, 2015, Pages 3878-3881

  Gao, Shuaihua ^a   Zhu, Shaozhou ^b   Huang, Rong ^a   Lu, Yingxiu ^a   Zheng, Guojun ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

(+) Lactamas; 2 Azabicyclo 2.2.1 hept 5 en 3 one; Enzymatic resolution; Site specific mutagenesis

Indexed keywords

ABACAVIR; CARBOVIR; GAMMA LACTAM DERIVATIVE; GAMMA LACTAMASE; METAL ION; PENICILLINASE; UNCLASSIFIED DRUG; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; AMIDASE; GAMMA-LACTAMASE;

ARTICLE; BACTERIAL GENOME; BRADYRHIZOBIUM JAPONICUM; CATALYST; CHIRALITY; CONTROLLED STUDY; DNA SEQUENCE; ENANTIOMER; ENZYME ACTIVITY; ENZYME CHEMISTRY; ENZYME STABILITY; ENZYME STRUCTURE; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PREDICTION; SITE DIRECTED MUTAGENESIS; SYNTHESIS; TEMPERATURE; THERMOSTABILITY; WILD TYPE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; STEREOISOMERISM;

BRADYRHIZOBIUM JAPONICUM;

AMIDOHYDROLASES; BIOCATALYSIS; DIDEOXYNUCLEOSIDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM;

EID: 84939264003     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.07.054     Document Type: Article

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