Assessment of chemokine receptor function on monocytes in whole blood: In vitro and ex vivo evaluations of a CCR2 antagonist

Journal of Immunological Methods

Volumn 352, Issue 1-2, 2010, Pages 101-110

  Wisniewski, T ^a   Bayne, E ^a   Flanagan, J ^a   Shao, Q ^a   Wnek, R ^a   Matheravidathu, S ^a   Fischer, P ^a   Forrest, M J ^a   Peterson, L ^a   Song, X ^a   Yang, L ^a   DeMartino, J A ^a   Struthers, M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CCR1; CCR2; CCR5; Cell recruitment; Cell shape change; MCP 1

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; MK 0812; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL MIGRATION; CELL SHAPE; CONTINUOUS INFUSION; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DRUG MECHANISM; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOADING DRUG DOSE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPRODUCIBILITY; RHESUS MONKEY; SENSITIVITY ANALYSIS;

ANIMALS; CELL MIGRATION ASSAYS, LEUKOCYTE; CELL MOVEMENT; CELL SHAPE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INJECTIONS, INTRAVENOUS; MACACA MULATTA; MONOCYTES; PHARMACEUTICAL PREPARATIONS; RECEPTORS, CCR2; SENSITIVITY AND SPECIFICITY; SKIN; SMALL MOLECULE LIBRARIES;

MACACA MULATTA;

EID: 71749102587     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2009.10.010     Document Type: Article

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