All-trans retinoic acid mitigates methotrexate-induced liver injury in rats; relevance of retinoic acid signaling pathway

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 9, 2015, Pages 931-938

  Ewees, Mohamed G ^a   Abdelghany, Tamer M ^a   Abdel Aziz, Abdel Aziz H ^a   Abdel Bakky, Mohamed S ^a,b  

^a Al Azhar University   (Egypt)

^b JOUF UNIVERSITY   (Saudi Arabia)

Author keywords

All trans retinoic acid; Hepatotoxicity; Methotrexate; Retinoic acid receptor; Retinoid X receptor

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; MALONALDEHYDE; METHOTREXATE; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; SUPEROXIDE DISMUTASE; IMMUNOSUPPRESSIVE AGENT; KERATOLYTIC AGENT; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER TOXICITY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; ANIMAL; DOWN REGULATION; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; DOWN-REGULATION; DRUG-INDUCED LIVER INJURY; IMMUNOSUPPRESSIVE AGENTS; KERATOLYTIC AGENTS; MALE; METHOTREXATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTOR ALPHA; SIGNAL TRANSDUCTION; TRETINOIN;

EID: 84939256351     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-015-1130-5     Document Type: Article

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