Mitochondrial coupling factor 6 upregulation in hypertension-induced cardiac hypertrophy;Hochregulation von „mitochondrial coupling factor 6“ bei hypertonieinduzierter kardialer Hypertrophie

Herz

Volumn 40, Issue 5, 2015, Pages 783-787

  He, Tao ^a,b   Guan, Aili ^b   Shi, Yue ^b   Ge, Zhiming ^a   Dai, Hongyan ^b  

^a SHANDONG UNIVERSITY   (China)

^b QINGDAO MUNICIPAL HOSPITAL   (China)

Author keywords

Cardiac hypertrophy; Fibrosis; Hypertension; Mitochondrial coupling factor 6, CF6; Spontaneously hypertensive rat model

Indexed keywords

MEMBRANE PROTEIN; MITOCHONDRIAL COUPLING FACTOR 6; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; COUPLING FACTOR; F(6) ATPASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CF6 GENE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HEART HEMODYNAMICS; HEART VENTRICLE HYPERTROPHY; HYPERTENSION INDUCED CARDIAC HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; CARDIOMEGALY; COMPLICATION; COUPLING FACTOR; HYPERTENSION; METABOLISM; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR RAT;

ANIMALS; BIOMARKERS; CARDIOMEGALY; HYPERTENSION; MALE; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OXIDATIVE PHOSPHORYLATION COUPLING FACTORS; RATS, INBRED SHR; RATS, WISTAR;

EID: 84939253573     PISSN: 03409937     EISSN: 16156692     Source Type: Journal    
DOI: 10.1007/s00059-015-4301-8     Document Type: Article

References (25)

1. Osanai T, Tanaka M, Kamada T et al (2001) Mitochondrial coupling factor 6 as a potent endogenous vasoconstrictor. J Clin Invest 108:1023–1030
2. Osanai T, Saitoh M, Sasaki S et al (2003) Effect of shear stress on asymmetric dimethylarginine release from vascular endothelial cells. Hypertension 42:985–990
3. Izumiyama K, Osanai T, Sagara S et al (2012) Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice. Hypertens Res 35:539–546
4. Sukekawa T, Osanai T, Nishizaki F et al (2013) Coupling factor 6 enhances the spontaneous microaggregation of platelets by decreasing cytosolic cAMP irrespective of antiplatelet therapy. Hypertens Res 36:520–527
5. Sagara S, Osanai T, Itoh T et al (2012) Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice. J Hypertens 30:778–786
6. Osanai T, Tanaka M, Magota K et al (2012) Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice. Diabetologia 55:520–529
7. Osanai T, Fujiwara N, Sasaki S et al (2010) Novel pro-atherogenic molecule coupling factor 6 is elevated in patients with stroke: a possible linkage to homocysteine. Ann Med 42:79–86
8. Osanai T, Magota K, Okumura K et al (2009) Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells. Naunyn Schmiedebergs Arch Pharmacol 380:205–214
9. Osanai T, Tomita H, Yamada M et al (2009) Coupling factor 6-induced prostacyclin inhibition is enhanced in vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens 27:1823–1828
10. Echizen T, Osanai T, Ashitate T et al (2009) Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in vascular endothelial cells: a role of acidosis-induced c-Src activation. Hypertens Res 32:182–187
11. Bueno OF, Molkentin JD (2002) Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death. Circ Res 91:776–781
12. Sadoshima J, Izumo S (1993) Molecular characterization of angiotensin-II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts-critical role of the at (1) receptor subtype. Circ Res 73:413–423
13. Drazner MH (2011) The progression of hypertensive heart disease. Circulation 123:327–334
14. Nadruz W (2015) Myocardial remodeling in hypertension. J Hum Hypertens (published 2014/05/08.) doi:10.1038/jhh.2014.36
15. Cohn JN, Ferrari R, Sharpe N et al (2000) Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 35:569–582
16. Mann DL (2002) Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 91:988–998
17. Jia L, Li Y, Xiao C et al (2012) Angiotensin II induces inflammation leading to cardiac remodeling. Front Biosci (Landmark Ed) 17:221–231
18. Shahbaz AU, Sun Y, Bhattacharya SK et al (2010) Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens 28:25–32
19. Osanai T, Matsumura H, Kikuchi T et al (1990) Changes in vascular wall production of prostacyclin and thromboxane A2 in spontaneously hypertensive rats during maturation and the concomitant development of hypertension. Jpn Circ J 54:507–514
20. Falardeau P, Robillard M, Martineau A (1985) Urinary levels of 2, 3-dinor-6-oxo-PGF1 alpha: a reliable index of the production of PGI2 in the spontaneously hypertensive rat. Prostaglandins 29:621–628
21. Osanai T, Kamada T, Fujiwara N et al (1998) A novel inhibitory effect on prostacyclin synthesis of coupling factor 6 extracted from the heart of spontaneously hypertensive rats. J Biol Chem 273:31778–31783
22. Ando J, Tsuboi H, Korenaga R et al (1996) Differential display and cloning of shear stress-responsive messenger RNAs in human endothelial cells. Biochem Biophys Res Commun 225:347–351
23. Osanai T, Okada S, Sirato K et al (2001) Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and is released by shear stress. Circulation 104:3132–3136
24. Osanai T, Tomita H, Kushibiki M et al (2009) Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells. Cardiovasc Res 81:780–787
25. Sen S, Tarazi RC, Khairallah PA et al (1974) Cardiac hypertrophy in spontaneously hypertensive rats. Circ Res 35:775–781