Coupling factor 6 as a novel vasoactive and proatherogenic peptide in vascular endothelial cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 3, 2009, Pages 205-214

  Osanai, Tomohiro ^a   Magota, Koji ^b   Okumura, Ken ^a  

^a HIROSAKI UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Coupling factor 6; Endothelial cells; Proatherogenic

Indexed keywords

CELL ADHESION MOLECULE; COUPLING FACTOR 6; CYTOSOLIC PHOSPHOLIPASE A2; ENDOTHELIN 2; ESTROGEN RECEPTOR BETA; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PROSTACYCLIN; PROTEIN KINASE C; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UROKINASE RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASOACTIVE AGENT;

ACIDOSIS; ACUTE HEART INFARCTION; ATHEROGENESIS; BETA CHAIN; BLOOD PRESSURE; CARBOXY TERMINAL SEQUENCE; CARDIOVASCULAR DISEASE; CELL MEMBRANE; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; KIDNEY FAILURE; PATHOGENESIS; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; SOLUBILITY; THROMBOCYTE ADHESION; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; ATHEROSCLEROSIS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; OXIDATIVE PHOSPHORYLATION COUPLING FACTORS; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

EID: 68349114997     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0431-y     Document Type: Review

References (42)

1. N Arakaki T Nagao R Niki A Toyofuku H Tanaka Y Kuramoto Y Emoto H Shibata K Magota T Higuti 2003 Possible role of cell surface H+-ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells Mol Cancer Res 1 931 939
2. 2 Prostag Other Lipid Mediat 71 217 234
3. K Berger U Sivars MS Winzell P Johansson U Hellman C Rippe C Erlanson-Albertsson 2002 Mitochondrial ATP synthase-a possible target protein in the regulation of energy metabolism in vitro and in vivo Nutr Neurosci 5 201 210
4. HE Burrell B Wlodarski BJ Foster KA Buckley GR Sharpe JM Quayle AW Simpson JA Gallagher 2005 Human keratinocytes release ATP and utilize three mechanisms for nucleotide interconversion at the cell surface J Biol Chem 280 29667 29676
5. NR Burwick ML Wahl J Fang Z Zhong TL Moser B Li RA Capaldi DJ Kenan SV Pizzo 2005 An inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface J Biol Chem 280 1740 1745
6. 6 from the peripheral stalk region of ATP synthase from bovine heart mitochondria J Mol Biol 342 593 603
7. SB Chai YM Hui XM Li CS Tang 2007 Plasma level of mitochondrial coupling factor 6 increases in patients with coronary heart disease Circ J 71 693 697
8. SY Chang SG Park S Kim CY Kang 2002 Interaction of the C-terminal domain of p43 and the alpha subunit of ATP synthase. Its functional implication in endothelial cell proliferation J Biol Chem 277 8388 8394
9. JK Chang P Scruggs J Yang M Ouyang A Duetzmann NJ Dun 2003 Total synthesis of human and rat coupling factor-6 amide and pressor effects in the rat Regul Pept 113 63 69
10. SL Chi SV Pizzo 2006 Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase Cancer Res 66 875 882
11. 1-ATPase and in its absence J Mol Biol 242 408 421
12. WH Ding SY Chu HF Jiang DY Cai YZ Pang CS Tang YF Qi 2004 Plasma mitochondrial coupling factor 6 in patients with acute myocardial infarction Hypertens Res 27 717 722
13. T Echizen T Osanai T Ashitate H Yokoyama S Shibutani M Tanaka H Tomita K Koji Magota K Okumura 2009 Upregulation of soluble vascular endothelial growth factor receptor type 1 by endogenous prostacyclin inhibitor coupling factor 6 in the vascular endothelial cells: a role of acidosis-induced c-Src activation Hypertens Res 32 182 187
14. +-ATP synthase in mitochondria Biochem Biophys Res Commun 178 793 799
15. H Itoh A Takahashi K Adachi H Noji R Yasuda Y Mand K Kinosita Jr 2004 Mechanically driven ATP synthesis by F1-ATPase Nature 427 465 468
16. A Kumagai T Osanai C Katoh M Tanaka H Tomita T Morimoto R Murakami K Magota K Okumura 2008 Coupling factor 6 downregulates platelet endothelial cell adhesion molecule-1 via c-Src activation and acts as a proatherogenic molecule Atherosclerosis 200 45 50
17. XL Li QC Xing B Dong YY Gao SS Xing YZ Pang HF Jiang CS Tang 2007 Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus Int J Cardiol 117 411 412
18. X Li S Xing L Zhang Q Xing S Yan H Dai S You Y Pang C Tang 2007 High glucose promotes the release and expression of novel vasoactive peptide, coupling factor 6, in human umbilical vein endothelial cells Peptides 28 683 690
19. LO Martinez S Jacquet JP Esteve C Rolland E Cabezon E Champagne T Pineau V Georgeaud JE Walker F Terce X Collet B Perret R Barbaras 2003 Ectopic β-chain of ATP synthase is an apolipoprotein A-I receptor in hepatic HDL endocytosis Nature 421 75 79
20. TL Moser MS Stack I Asplin JJ Enghild P Hojrup L Everitt S Hubchak HW Schnaper SV Pizzo 1999 Angiostatin binds ATP synthase on the surface of human endothelial cells Proc Natl Acad Sci U S A 96 2811 2816
21. o ATP synthase is active in ATP synthesis and is inhibited by angiostatin Proc Natl Acad Sci U S A 98 6656 6661
22. T Osanai T Kamada N Fujiwara T Katoh K Takahashi M Kimura K Satoh K Magota S Kodama T Tanaka K Okumura 1998 A novel inhibitory effect on prostacyclin synthesis of coupling factor 6 extracted from the heart of spontaneously hypertensive rats J Biol Chem 273 31778 31783
23. T Osanai S Okada K Sirato T Nakano M Saitoh K Magota K Okumura 2001 Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and released by shear stress Circulation 104 3132 3136
24. T Osanai M Tanaka T Kamada T Nakano K Takahashi S Okada K Sirato K Magota S Kodama K Okumara 2001 Mitochondrial coupling factor 6 as a novel endogenous vasoconstrictor J Clin Invest 108 1023 1030
25. T Osanai M Nakamura S Sasaki H Tomita M Saitoh H Osawa H Yamabe S Murakami K Magota K Okumura 2003 Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease Kidney Int 64 2291 2297
26. T Osanai S Sasaki T Kamada N Fujiwara T Nakano H Tomita T Matsunaga K Magota K Okumura 2003 Circulating coupling factor 6 in human hypertension: role of reactive oxygen species J Hypertens 21 2323 2328
27. T Osanai K Magota M Tanaka M Shimada R Murakami S Sasaki H Tomita N Maeda K Okumura 2005 Intracellular signaling for vasoconstrictor coupling factor 6: novel function of β-subunit of ATP synthase as receptor Hypertension 46 1140 1146
28. T Osanai H Tomita M Kushibiki M Yamada M Tanaka T Ashitate T Echizen C Katoh K Magota K Okumura 2009 Coupling factor 6 enhances Src-mediated responsiveness to angiotensin II in resistance arterioles and cells Cardiovasc Res 81 780 787
29. M Park L Lin S Thomas HD Braymer PM Smith DH Harrison DA York 2004 The F1-ATPase beta-subunit is the putative enterostatin receptor Peptides 25 2127 2133
30. JL Rubinstein VK Dickson MJ Runswick JE Walker 2005 ATP synthase from Saccharomyces cerevisiae: location of subunit h in the peripheral stalk region J Mol Biol 345 513 520
31. S Sasaki T Osanai H Tomita T Matsunaga K Magota K Okumura 2004 Tumor necrosis factor α as an endogenous stimulator for circulating coupling factor 6 Cardiovasc Res 62 578 586
32. C Schmidt E Lepsverdize SL Chi AM Das SV Pizzo A Dityatev M Schachner 2008 Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulates its activity at the surface of neural cells Mol Psychiatry 13 953 969
33. E Scotet LO Martinez E Grant R Barbaras P Jenö M Guiraud B Monsarrat X Saulquin S Maillet JP Estève F Lopez B Perret X Collet M Bonneville E Champagne 2005 Tumor recognition following Vgamma9Vdelta2 T cell receptor interactions with a surface F1-ATPase-related structure and apolipoprotein A-I Immunity 22 71 80
34. AE Senior 1992 Catalytic sites of Escherichia coli F1-ATPase J Bioenerg Biomembr 24 479 484
35. M Tanaka T Osanai R Murakami S Sasaki H Tomita N Maeda K Satoh K Magota K Okumura 2006 Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine J Hypertens 24 489 497
36. H Tomita T Osanai T Toki S Sasaki N Maeda R Murakami K Magota M Yasujima K Okumura 2005 Troglitazone and 15-deoxy-delta12, 14-prostaglandin J2 inhibit shear-induced coupling factor 6 release in endothelial cells Cardiovasc Res 67 134 141
37. E Tzima M Irani-Tehrani WB Kiosses E Dejana DA Schultz B Engelhardt G Cao H DeLisser MA Schwartz 2005 A mechanosensory complex that mediates the endothelial cell response to fluid shear stress Nature 437 426 431
38. P Vantourout LO Martinez A Fabre X Collet E Champagne 2008 Ecto-F1-ATPase and MHC-class I close association on cell membranes Mol Immunol 45 485 492
39. JE Walker VK Dickson 2006 The peripheral stalk of the mitochondrial ATP synthase Biochim Biophys Acta 1757 286 296
40. K Yamamoto N Shimizu S Obi S Kumagaya Y Taketani A Kamiya J Ando 2007 Involvement of cell surface ATP synthase in flow-induced ATP release by vascular endothelial cells Am J Physiol Heart Circ Physiol 293 H1646 H1653
41. SK Yonally RA Capaldi 2006 The F1Fo ATP synthase and mitochondrial respiratory chain complexes are present on the plasma membrane of an osteosarcoma cell line: an immunocytochemical study Mitochondrion 6 305 314
42. M Yoshida E Muneyuki T Hisabori 2001 ATP synthase-a marvellous rotary engine of the cell Nature Rev Mol Cell Biol 2 669 677 (Pubitemid 33674070)