Emerging roles for macrophages in cardiac injury: Cytoprotection, repair, and regeneration

Journal of Clinical Investigation

Volumn 125, Issue 8, 2015, Pages 2927-2930

  Frangogiannis, Nikolaos G ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL INFILTRATION; CELL PROTECTION; CELL SURVIVAL; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART REGENERATION; MACROPHAGE FUNCTION; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; TISSUE REGENERATION; ANIMAL; APOPTOSIS; FEMALE; HEART INFARCTION; MACROPHAGE; METABOLISM; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; FEMALE; MACROPHAGES; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC;

EID: 84939228160     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI83191     Document Type: Note

References (24)

1. Epelman S, et al. Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity. 2014;40(1):91-104.
2. Heidt T, et al. Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res. 2014;115(2):284-295.
3. Mylonas KJ, et al. The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment adopts an 'M2' phenotype in response to Th2 immunologic challenge. Immunobiology. 2015;220(7):924-933.
4. Dewald O, et al. CCL2/Monocyte chemoattractant protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res. 2005;96(8):881-889.
5. Hilgendorf I, et al. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res. 2014;114(10):1611-1622.
6. Simms MG, Walley KR. Activated macrophages decrease rat cardiac myocyte contractility: importance of ICAM-1-dependent adhesion. Am J Physiol. 1999;277(1 pt 2):H253-H260.
7. Trial J, Rossen RD, Rubio J, Knowlton AA. Inflammation and ischemia: macrophages activated by fibronectin fragments enhance the survival of injured cardiac myocytes. Exp Biol Med. 2004;229(6):538-545.
8. Marban E. Breakthroughs in cell therapy for heart disease: focus on cardiosphere-derived cells. Mayo Clin Proc. 2014;89(6):850-858.
9. de Couto G, et al. Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J Clin Invest. 2015;125(8):3147-3162.
10. Aurora AB, et al. Macrophages are required for neonatal heart regeneration. J Clin Invest. 2014;124(3):1382-1392.
11. Lavine KJ, et al. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. Proc Natl Acad Sci U S A. 2014;111(45):16029-16034.
12. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977;56(5):786-794.
13. Korf-Klingebiel M, et al. Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med. 2015;21(2):140-149.
14. Dhingra S, Sharma AK, Arora RC, Slezak J, Singal PK. IL-10 attenuates TNF-α-induced NFκB pathway activation and cardiomyocyte apoptosis. Cardiovasc Res. 2009;82(1):59-66.
15. Zen K, Masuda J, Ogata J. Monocyte-derived macrophages prime peripheral T cells to undergo apoptosis by cell-cell contact via ICAM-1/ LFA-1-dependent mechanism. Immunobiology. 1996;195(3):323-333.
16. Meszaros AJ, Reichner JS, Albina JE. Macrophage-induced neutrophil apoptosis. J Immunol. 2000;165(1):435-441.
17. Okada H, et al. Integrins protect cardiomyocytes from ischemia/reperfusion injury. J Clin Invest. 2013;123(10):4294-4308.
18. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol. 2010;48(3):504-511.
19. Frangogiannis NG. Matricellular proteins in cardiac adaptation and disease. Physiol Rev. 2012;92(2):635-688.
20. Frantz S, et al. Monocytes/macrophages prevent healing defects and left ventricular thrombus formation after myocardial infarction. FASEB J. 2013;27(3):871-881.
21. Dutta P, Nahrendorf M. Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol. 2015;35(5):1066-1070.
22. Wan E, et al. Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid-epithelial-reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction. Circ Res. 2013;113(8):1004-1012.
23. Porrello ER, et al. Transient regenerative potential of the neonatal mouse heart. Science. 2011;331(6020):1078-1080.
24. Frangogiannis NG, et al. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol. 2003;285(2):H483-H492.