Common genetic variation in cellular transport genes and epithelial ovarian cancer (EOC) risk

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Chornokur, Ganna ^a   Lin, Hui Yi ^a   Tyrer, Jonathan P ^b   Lawrenson, Kate ^c   Dennis, Joe ^b   Amankwah, Ernest K ^a,d   Qu, Xiaotao ^a   Tsai, Ya Yu ^a   Jim, Heather S L ^a   Chen, Zhihua ^a   Chen, Ann Y ^a   Permuth Wey, Jennifer ^a   Aben, Katja K H ^e,f   Anton Culver, Hoda ^g   Antonenkova, Natalia ^h   Bruinsma, Fiona ⁱ   Bandera, Elisa V ^j   Bean, Yukie T ^k,l   Beckmann, Matthias W ^m   Bisogna, Maria ⁿ   Bjorge, Line ^o,p   Bogdanova, Natalia ^q   Brinton, Louise A ^r   Brooks Wilson, Angela ^s,t   Bunker, Clareann H ^u   Butzow, Ralf ^v,w   Campbell, Ian G ^x,y   Carty, Karen ^z,aa   Chang Claude, Jenny ^ab   Cook, Linda S ^ac   Cramer, Daniel W ^ad   Cunningham, Julie M ^ae   Cybulski, Cezary ^af   Dansonka Mieszkowska, Agnieszka ^ag   Du Bois, Andreas ^ah,ai   Despierre, Evelyn ^aj   Dicks, Ed ^b   Doherty, Jennifer A ^al,am   Dörk, Thilo ^q   Dürst, Matthias ^an   Easton, Douglas F ^c,ak   Eccles, Diana M ^ao   Edwards, Robert P ^ap   Ekici, Arif B ^aq   Fasching, Peter A ^m,ar   Fridley, Brooke L ^as   Gao, Yu Tang ^at   Gentry Maharaj, Aleksandra ^au   Giles, Graham G ^i,y   Glasspool, Rosalind ^aa   Goodman, Marc T ^av   Gronwald, Jacek ^af   Harrington, Patricia ^ak   Harter, Philipp ^ah,ai   Hein, Alexander ^m   Heitz, Florian ^ah,ai   Hildebrandt, Michelle A T ^aw   Hillemanns, Peter ^q   Hogdall, Claus K ^ax   Hogdall, Estrid ^ax,ay   Hosono, Satoyo ^az   Jakubowska, Anna ^af   Jensen, Allan ^ay   Ji, Bu Tian ^r   Karlan, Beth Y ^av   Kelemen, Linda E ^ba   Kellar, Mellissa ^k,l   Kiemeney, Lambertus A ^e   Krakstad, Camilla ^o,p   Kjaer, Susanne K ^ax,ay   Kupryjanczyk, Jolanta ^ag   Lambrechts, Diether ^bb,bc   Lambrechts, Sandrina ^aj   Le, Nhu D ^s   Lee, Alice W ^c   Lele, Shashi ^bd   Leminen, Arto ^v   Lester, Jenny ^av   Levine, Douglas A ⁿ   Liang, Dong ^be   Lim, Boon Kiong ^bf   Lissowska, Jolanta ^ag   Lu, Karen ^aw   Lubinski, Jan ^af   Lundvall, Lene ^ax   Massuger, Leon F A G ^e   Matsuo, Keitaro ^az   McGuire, Valerie ^bg   McLaughlin, John R ^bh   McNeish, Iain ^bi   Menon, Usha ^au   Milne, Roger L ⁱ   Modugno, Francesmary ^u,ap,bj   Moysich, Kirsten B ^bd   Ness, Roberta B ^bk   Nevanlinna, Heli ^v   Eilber, Ursula ^ab   Odunsi, Kunle ^bd   Olson, Sara H ⁿ   Orlow, Irene ⁿ   Orsulic, Sandra ^av   Weber, Rachel Palmieri ^bl   Paul, James ^aa   Pearce, Celeste L ^c,bm   Pejovic, Tanja ^k,l   Pelttari, Liisa M ^v   Pike, Malcolm C ^c,n   Poole, Elizabeth M ^ad,bn   Risch, Harvey A ^bo   Rosen, Barry ^bp   Rossing, Mary Anne ^am   Rothstein, Joseph H ^bg   Rudolph, Anja ^ab   Runnebaum, Ingo B ^an   Rzepecka, Iwona K ^ag   Salvesen, Helga B ^o,p   Schernhammer, Eva ^ad,bn   Schwaab, Ira ^bq   Shu, Xiao Ou ^br   Shvetsov, Yurii B ^bs   Siddiqui, Nadeem ^z   Sieh, Weiva ^bg   Song, Honglin ^b   Southey, Melissa C ^y   Spiewankiewicz, Beata ^ag   Sucheston, Lara ^bd   Teo, Soo Hwang ^bf,bt   Terry, Kathryn L ^ad   Thompson, Pamela J ^av   Thomsen, Lotte ^ax   Tangen, Ingvild L ^o,p   Tworoger, Shelley S ^ad,bn   Van Altena, Anne M ^e   Vierkant, Robert A ^ae   Vergote, Ignace ^aj   Walsh, Christine S ^av   Wang Gohrke, Shan ^ab   Wentzensen, Nicolas ^r   Whittemore, Alice S ^bg   Wicklund, Kristine G ^am   Wilkens, Lynne R ^bs   Wu, Anna H ^c   Wu, Xifeng ^aw   Woo, Yin Ling ^bf   Yang, Hannah ^r   Zheng, Wei ^bu   Ziogas, Argyrios ^g   Hasmad, Hanis N ^bt   Berchuck, Andrew ^bl   Chenevix Trench, Georgia ^x,bv   Iversen, Edwin S ^bw   Schildkraut, Joellen M ^bx   Ramus, Susan J ^c   Goode, Ellen L ^ae   Monteiro, Alvaro N A ^a   Gayther, Simon A ^c   Narod, Steven A ^bp   Pharoah, Paul D P ^b,ak   Sellers, Thomas A ^a   Phelan, Catherine M ^a   more..

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d JOHNS HOPKINS ALL CHILDREN S HOSPITAL   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^f Netherlands Comprehensive Cancer Organisation   (Netherlands)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h Unit N N Alexandrov National Cancer   (Belarus)

ⁱ CANCER EPIDEMIOLOGY CENTRE   (Australia)

^j RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^k OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^l OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^m UNIVERSITY HOSPITAL ERLANGEN   (Germany)

ⁿ MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^o HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^p UNIVERSITY OF BERGEN   (Norway)

^q HANNOVER MEDICAL SCHOOL   (Germany)

^r NATIONAL CANCER INSTITUTE   (United States)

^s BRITISH COLUMBIA CANCER AGENCY   (Canada)

^t SIMON FRASER UNIVERSITY   (Canada)

^u UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^v UNIVERSITY OF HELSINKI   (Finland)

^w HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^x PETER MACCALLUM CANCER CENTRE   (Australia)

^y UNIVERSITY OF MELBOURNE   (Australia)

^z GLASGOW ROYAL INFIRMARY   (United Kingdom)

^aa BEATSON WEST OF SCOTLAND CANCER CENTRE   (United Kingdom)

^ab GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^ac UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^ad HARVARD MEDICAL SCHOOL   (United States)

^ae MAYO CLINIC   (United States)

^af POMERANIAN MEDICAL UNIVERSITY   (Poland)

^ag INSTITUTE OF ONCOLOGY   (Poland)

^ah KLINIKEN ESSEN MITTE   (Germany)

^ai DR HORST SCHMIDT KLINIKEN   (Germany)

^aj UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^ak UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^al DARTMOUTH MEDICAL SCHOOL   (United States)

^am UNIVERSITY OF WASHINGTON   (United States)

^an JENA UNIVERSITY HOSPITAL   (Germany)

^ao UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^ap UNIVERSITY OF PITTSBURGH   (United States)

^aq UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^ar UNIVERSITY OF CALIFORNIA   (United States)

^as UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^at SHANGHAI CANCER INSTITUTE   (China)

^au UNIVERSITY COLLEGE LONDON   (United Kingdom)

^av CEDARS SINAI MEDICAL CENTER   (United States)

^aw UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^ax UNIVERSITY OF COPENHAGEN   (Denmark)

^ay DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^az KYUSHU UNIVERSITY   (Japan)

^ba MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^bb DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^bc UNIVERSITY OF LEUVEN   (Belgium)

^bd ROSWELL PARK CANCER INSTITUTE   (United States)

^be TEXAS SOUTHERN UNIVERSITY   (United States)

^bf UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^bg STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bh PUBLIC HEALTH ONTARIO   (Canada)

^bi UNIVERSITY OF GLASGOW   (United Kingdom)

^bj UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^bk UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^bl DUKE UNIVERSITY MEDICAL CENTER   (United States)

^bm UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^bn HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^bo YALE UNIVERSITY   (United States)

^bp UNIVERSITY OF TORONTO   (Canada)

^bq Institut Für Humangenetik Wiesbaden   (Germany)

^br VANDERBILT INGRAM CANCER CENTER   (United States)

^bs UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^bt CANCER RESEARCH INITIATIVES FOUNDATION   (Malaysia)

^bu VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^bv QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^bw DUKE UNIVERSITY   (United States)

^bx DUKE CANCER INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HEPHAESTIN; CARRIER PROTEIN;

ARTICLE; CANCER RISK; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HEPH GENE; HUMAN; MAJOR CLINICAL STUDY; MGST1 GENE; OVARY CARCINOMA; SERPINA GENE; SERPINA7 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; SLC25A45 GENE; SLC39A11 GENE; UGT1A GENE; AFRICAN AMERICAN; ALLELE; ASIAN AMERICAN; CASE CONTROL STUDY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; METABOLISM; NEOPLASMS, GLANDULAR AND EPITHELIAL; ODDS RATIO; OVARIAN NEOPLASMS; PATHOLOGY; RISK; TRANSPORT AT THE CELLULAR LEVEL;

AFRICAN AMERICANS; ALLELES; ASIAN AMERICANS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; NEOPLASMS, GLANDULAR AND EPITHELIAL; ODDS RATIO; OVARIAN NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84939197812     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0128106     Document Type: Article

References (70)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011). Global cancer statistics. CA Cancer J Clin 61: 69-90. doi: 10.3322/caac.20107 PMID: 21296855
2. Buys SS, Partridge E, Black A, Johnson CC, Lamerato L, Isaacs C, et al. (2011) Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 305: 2295-2303. doi: 10.1001/jama.2011.766 PMID: 21642681
3. Ries LAG, Young Jr JL, Keel GE, Eisner MP, Lin YD, Horner MJD. (2007) Cancer survival among adults: US SEER program, 1988-2001. Patient and tumor characteristics SEER Survival Monograph Publication: 07-6215.
4. Macheda ML, Rogers S, Best JD (2005) Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202: 654-662. PMID: 15389572
5. Guilbert A, Gautier M, Dhennin-Duthille I, Haren N, Sevestre H, Ouadid-Ahidouch H. (2009) Evidence that TRPM7 is required for breast cancer cell proliferation. Am J Physiol Cell Physiol 297: C493-502. doi: 10.1152/ajpcell.00624.2008 PMID: 19515901
6. Pinheiro C, Sousa B, Albergaria A, Paredes J, Dufloth R, Vieira D, et al. (2011) GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression. Histol Histopathol 26: 1279-1286. PMID: 21870331
7. Ota I, Sakurai A, Toyoda Y, Morita S, Sasaki T, Chishima T, et al. (2010) Association between Breast Cancer Risk and the Wild-type Allele of Human ABC Transporter ABCC11. Anticancer Research 30(12): 5189-5194 PMID: 21187511
8. Pertega-Gomes N, Vizcaino JR, Miranda-Goncalves V, Pinheiro C, Silva J, Pereira H, et al. (2011) Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer. BMC Cancer 11: 312. doi: 10.1186/1471-2407-11-312 PMID: 21787388
9. Chen J, Chloupkova M (2009) Abnormal iron uptake and liver cancer. Cancer Biol Ther 8: 1699-1708. PMID: 19571663
10. Kurzawski M, Droździk M, Suchy J, Kurzawski G, Białecka M, Górnik W, et al. (2005) Polymorphism in the P-glycoprotein drug transporter MDR1 gene in colon cancer patients. European Journal of Clinical Pharmacology 61(5-6): 389-394
11. Zhang H, Liao L- H, Liu S- M, Lau KW, Lai AK, Zhang JH, et al. (2007) Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. International Journal of Colorectal Disease 22(10): 1185-1194 PMID: 17483957
12. Cross AJ, Sinha R, Wood RJ, Xue X, Huang WY, et al. (2011) Iron homeostasis and distal colorectal adenoma risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Prev Res (Phila) 4: 1465-1475. doi: 10.1158/1940-6207.CAPR-11-0103 PMID: 21685236
13. Filetti S, Bidart JM, Arturi F, Caillou B, Russo D, Schlumberger M. (1999) Sodium/iodide symporter: a key transport system in thyroid cancer cell metabolism. Eur J Endocrinol 141: 443-457. PMID: 10576759
14. Ishihara T, Inoue J, Kozaki K, Imoto I, Inazawa J (2011) HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death. J Biol Chem 286: 44086-44094. doi: 10.1074/jbc.M111.251694 PMID: 22009753
15. Nemeth E (2008) Iron regulation and erythropoiesis. Curr Opin Hematol 15: 169-175. doi: 10.1097/MOH.0b013e3282f73335 PMID: 18391780
16. Lenaz G, Baracca A, Barbero G, Bergamini C, Dalmonte ME, Del Sole M, et al. (2010) Mitochondrial respiratory chain super-complex I-III in physiology and pathology. Biochim Biophys Acta 1797: 633-640. doi: 10.1016/j.bbabio.2010.01.025 PMID: 20116362
17. Foy SP, Labhasetwar V (2011) Oh the irony: Iron as a cancer cause or cure? Biomaterials 32: 9155-9158. doi: 10.1016/j.biomaterials.2011.09.047 PMID: 21963282
18. Iron Atlas. Available: http://wwwironatlascom.
19. Huang X (2003) Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 533(1-2): 153-171
20. Lin SF, Wei H, Maeder D, Franklin RB, Feng P (2009) Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study. J Nutr Biochem 20: 1000-1012. doi: 10.1016/j.jnutbio.2008.09.004 PMID: 19071009
21. Kurian AW, Balise RR, McGuire V, Whittemore AS (2005) Histologic types of epithelial ovarian cancer: have they different risk factors? Gyn Oncol 96: 520-530. PMID: 15661246
22. Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, et al. (2013) GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 45: 362-370, 370e361-362. doi: 10.1038/ng.2564 PMID: 23535730
23. "Gene" database by NCBI: http://www.ncbi.nlm.nih.gov/gene
24. "BioCarta" database: http://www.biocarta.com/
25. "GenomeNet" database: http://www.genome.jp/
26. Howie BN, Donnelly P, Marchini J (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genetics 5(6): e1000529. doi: 10.1371/journal.pgen.1000529 PMID: 19543373
27. Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis GR (2012) Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nature Genetics 44(8): 955-959. doi: 10.1038/ng.2354 PMID: 22820512
28. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. Sep 2007; 81(3):559-575. PMID: 17701901
29. Petitti D. Meta-analysis decision analysis and cost-effectiveness analysis. New York: Oxford; 1994.
30. Sankararaman S, Sridhar S, Kimmel G, Halperin E. Estimating local ancestry in admixed populations. Am. J. Hum. Genet. Feb 2008; 82(2):290-303. doi: 10.1016/j.ajhg.2007.09.022 PMID: 18252211
31. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. Aug 2006; 38(8):904-909. PMID: 16862161
32. Storey JD. A direct approach to false discovery rates. Journal of the Royal Statistical Society: Series B 2002; 64:479-98.
33. Anderson AS, Roberts PC, Frisard MI, McMillan RP, Brown TJ, Lawless MH (2013) Metabolic changes during ovarian cancer progression as targets for sphingosine treatment. Exp Cell Res. 10; 319(10):1431-42. doi: 10.1016/j.yexcr.2013.02.017 PMID: 23518387
34. Fleming RE, Sly WS (2003) The iron gatekeeper: keys to the front and back doors. Blood 102: 1567-1567.
35. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, et al. (1999) Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 21: 195-199. PMID: 9988272
36. Li L, Vulpe CD, Kaplan J (2003) Functional studies of hephaestin in yeast: evidence for multicopper oxidase activity in the endocytic pathway. Biochem J 375: 793-798. PMID: 12921533
37. Sebastiani G, Pantopoulos K (2010) Iron Metabolism and Disease. In: Zalups RK, Koropatnick DJ, editors. Cellular and molecular biology of metals: CRC Press.
38. Yeh KY, Yeh M, Glass J (2011) Interactions between ferroportin and hephaestin in rat enterocytes are reduced after iron ingestion. Gastroenterology 141: 292-299. e291. doi: 10.1053/j.gastro.2011.03.059 PMID: 21473866
39. Merlot AM, Kalinowski DS, Richardson DR (2013) Novel chelators for cancer treatment: where are we now? Antioxid Redox Signal 18: 973-1006. doi: 10.1089/ars.2012.4540 PMID: 22424293
40. Galaris D, Pantopoulos K (2008) Oxidative stress and iron homeostasis: mechanistic and health aspects. Crit Rev Clin Lab Sci 45: 1-23. doi: 10.1080/10408360701713104 PMID: 18293179
41. E Abu Z Dayem Ullah, Nicholas R Lemoine and Claude Chelala, A practical guide for the functional annotation of genetic variations using SNPnexus 〈http://bib.oxfordjournals.org/content/early/2013/02/08/bib.bbt004.abstract〉, Briefings in Bioinformatics, 2013, doi: 10.1093/bib/bbt004
42. Zongli Xu, Jack A. Taylor (2009). SNPinfo: Integrating GWAS and Candidate Gene Information into Functional SNP Selection for Genetic Association Studies. Nucleic Acids Research
43. Wang K, Li M, Hakonarson H. ANNOVAR: Functional annotation of genetic variants from next-generation sequencing data 〈http://nar.oxfordjournals.org/content/38/16/e164〉 Nucleic Acids Research, 38: e164, 2010
44. Brookes MJ, Hughes S, Turner FE, Reynolds G, Sharma N, Ismail T, et al. (2006) Modulation of iron transport proteins in human colorectal carcinogenesis. Gut 55: 1449-1460. PMID: 16641131
45. The Cancer Genome Atlas: http://cancergenome.nih.gov/
46. Eide DJ (2004) The SLC39 family of metal ion transporters. Pflugers Arch 447: 796-800. PMID: 12748861
47. Taylor KM, Morgan HE, Smart K, Zahari NM, Pumford S, Ellis IO, et al. (2007) The emerging role of the LIV-1 subfamily of zinc transporters in breast cancer. Mol Med 13: 396-406. PMID: 17673939
48. Palmieri F (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 447: 689-709. PMID: 14598172
49. Haitina T, Lindblom J, Renstrom T, Fredriksson R (2006) Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Genomics 88: 779-790. PMID: 16949250
50. Palmieri F (2013) The mitochondrial transporter family SLC25: identification, properties and physiopathology. Mol Aspects Med 34: 465-484. doi: 10.1016/j.mam.2012.05.005 PMID: 23266187
51. Iacobazzi V, Invernizzi F, Baratta S, Pons R, Chung W, Garavaqlia B, et al. (2004) Molecular and functional analysis of SLC25A20 mutations causing carnitine-acylcarnitine translocase deficiency. Hum Mutat 24: 312-320. PMID: 15365988
52. Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, et al. (2006) An overview of the serpin superfamily. Genome Biol 7: 216. PMID: 16737556
53. Domingues R, Font P, Sobrinho L, Bugalho MJ (2009) A novel variant in Serpina7 gene in a family with thyroxine-binding globulin deficiency. Endocrine 36: 83-86. doi: 10.1007/s12020-009-9202-2 PMID: 19415532
54. Lacka K, Nizankowska T, Ogrodowicz A, Lacki JK (2007) A Novel Mutation (del 1711 G) in the TBG Gene as a Cause of Complete TBG Deficiency. Thyroid 17(11): 1143-1146. PMID: 17887925
55. Kobayashi H, Sakurai A, Katai M, Hashizume K (1999) Autosomally Transmitted Low Concentration of Thyroxine-Binding Globulin Thyroid 9(2): 159-163. PMID: 10090316
56. Cristofanilli M, Yamamura Y, Kau SW, Bevers T, Strom S, Patangan M, et al. (2005) Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer 103: 1122-1128. PMID: 15712375
57. Frumovitz M, Schmeler KM, Malpica A, Sood AK, Gershenson DM (2010) Unmasking the complexities of mucinous ovarian carcinoma. Gynecol Oncol 117: 491-496. doi: 10.1016/j.ygyno.2010.02.010 PMID: 20332054
58. Shimada M, Kigawa J, Ohishi Y, Yasuda M, Suzuki M, Hiura M, et al. (2009) Clinicopathological characteristics of mucinous adenocarcinoma of the ovary. Gynecol Oncol 113: 331-334. doi: 10.1016/j.ygyno.2009.02.010 PMID: 19275957
59. Risch HA, Marrett LD, Jain M, Howe GR. Differences in Risk Factors for Epithelial Ovarian Cancer by Histologic Type. Am J Epidemiol 1996; 144(4):363-72. PMID: 8712193
60. Levesque E, Girard H, Journault K, Lepine J, Guillemette C (2007) Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 45: 128-138. PMID: 17187418
61. Tukey RH, Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40: 581-616. PMID: 10836148
62. Araki J, Kobayashi Y, Iwasa M, Urawa N, Gabazza EC, Taquchi O, et al. (2005) Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer. Eur J Cancer 41: 2360-2365. PMID: 16143514
63. Duguay Y, McGrath M, Lepine J, Gagne JF, Hankinson SE, Colditz GA, et al. (2004) The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk. Cancer Res 64: 1202-1207. PMID: 14871858
64. Ockenga J, Vogel A, Teich N, Keim V, Manns MP, Strassburg CP. (2003) UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer. Gastroenterology 124: 1802-1808. PMID: 12806614
65. Giuliani L, Ciotti M, Stoppacciaro A, Pasquini A, Silvestri I, De Matteis A, et al. (2005) UDP-glucuronosyltransferases1A expression in human urinary bladder and colon cancer by immunohistochemistry. Oncol Rep 13: 185-191. PMID: 15643497
66. Morgenstern R, Zhang J, Johansson K (2011) Microsomal glutathione transferase 1: mechanism and functional roles. Drug Metab Rev 43: 300-306. doi: 10.3109/03602532.2011.558511 PMID: 21495795
67. Nicolle M. Linnerth, Kelly Sirbovan, Roger A. Moorehead. Use of a transgenic mouse model to identify markers of human lung tumors. International Journal of Cancer Volume 114, Issue 6, pages 977-982, 10 May 2005 PMID: 15645424
68. H Chaib EK Cockrell, MA Rubin, JA Macoska. Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis. Neoplasia 3(1), 2001, p 42-52
69. Thea Eline Hetland Dag Andre Nymoen, Emilsen Elisabeth, Kaern J, et al. (2012) MGST1 expression in serous ovarian carcinoma differs at various anatomic sites, but is unrelated to chemoresistance or survival. Gyn oncol 126 (3):460-5 doi: 10.1016/j.ygyno.2012.05.029 PMID: 22652154
70. Chornokur G, Amankwah EK, Schildkraut JM, Phelan CM (2013) Global ovarian cancer health disparities. Gynecol Oncol 129: 258-264. doi: 10.1016/j.ygyno.2012.12.016 PMID: 23266352