Trauma resuscitation requiring massive transfusion: A descriptive analysis of the role of ratio and time

World Journal of Emergency Surgery

Volumn 10, Issue 1, 2015, Pages

  Peralta, Ruben ^a   Vijay, Adarsh ^a   El Menyar, Ayman ^a,b   Consunji, Rafael ^a   Abdelrahman, Husham ^a   Parchani, Ashok ^a   Afifi, Ibrahim ^a   Zarour, Ahmad ^a,b   Al Thani, Hassan ^a   Latifi, Rifat ^a,c  

^a HAMAD GENERAL HOSPITAL   (Qatar)

^b WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Massive transfusion protocol; Outcome; Transfusion ratio; Trauma

Indexed keywords

EID: 84939165178     PISSN: None     EISSN: 17497922     Source Type: Journal    
DOI: 10.1186/s13017-015-0028-3     Document Type: Article

References (26)

1. Peng R, Chang C, Gilmore D, Bongard F. Epidemiology of immediate and early trauma deaths at an urban Level I trauma center. Am Surg. 1998;64:950-4.
2. Demetriades D, Murray J, Charalambides K, Alo K, Velmahos G, Rhee P, et al. Trauma fatalities: time and location of hospital deaths. J Am Coll Surg. 2004;198:20-6.
3. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127-30.
4. Borgman MA, Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma. 2007;63:805-13.
5. Sperry JL, Ochoa JB, Gunn SR, Alarcon LH, Minei JP, Cuschieri J, et al. Inflammation the Host Response to Injury Investigators: An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion. J Trauma. 2008;65:986-93.
6. Gajic O, Dzik WH, Toy P. Fresh frozen plasma and platelet transfusion for non-bleeding patients in the intensive care unit: benefit or harm? Crit Care Med. 2006;34 Suppl 5:170-3.
7. MacLennan S, Williamson LM. Risks of fresh frozen plasma and platelets. J Trauma. 2006;60 Suppl 6:46-50.
8. Silliman CC, Ambruso DR, Boshkov LK. Transfusion-related acute lung injury. Blood. 2005;105:2266-73.
9. Dutton RP. Resuscitative strategies to maintain homeostasis during damage control surgery. Br J Surg. 2012;99 Suppl 1:21-8.
10. Meißner A, Schlenke P. Massive Bleeding and Massive Transfusion. Transfus Med Hemother. 2012;39:73-84.
11. Minei JP, Nathens AB, West M, Harbrecht BG, Moore EE, Shapiro MB, et al. Inflammation and the Host Response to Injury Large Scale Collaborative Research Program Investigators. Inflammation and the Host Response to Injury, a Large-Scale Collaborative Project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP) in the trauma patient. J Trauma. 2006;60:1106-13.
12. Kashuk JL, Moore EE, Millikan JS, Moore JB. Major abdominal vascular trauma - a unified approach. J Trauma. 1982;22:672-9.
13. Kautza BC, Cohen MJ, Cuschieri J, Minei JP, Brackenridge SC, Maier RV, et al. Inflammation and the Host Response to Injury Investigators: Changes in massive transfusion over time: an early shift in the right direction? J Trauma Acute Care Surg. 2012;72:106-11.
14. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248:447-58.
15. Gunter Jr OL, Au BK, Isbell JM, Mowery NT, Young PP, Cotton BA. Optimizing outcomes in damage control resuscitation: identifying blood product ratios associated with improved survival. J Trauma. 2008;65:527-34.
16. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B. Working Group on Polytrauma of the German Society of Trauma Surgery (DGU). Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft für Unfallchirurgie. Vox Sang. 2008;95:112-19.
17. Snyder CW, Weinberg JA, McGwin Jr G, Melton SM, George RL, Reiff DA, et al. The relationship of blood product ratio to mortality: Survival benefit or survival bias? J Trauma. 2009;66:358-62.
18. Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, et al. Impact of plasma transfusion in massively transfused trauma patients. J Trauma. 2009;66:693-7.
19. Mitra B, Mori A, Cameron PA, Fitzgerald M, Paul E, Street A. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury. 2010;41:35-9.
20. Magnotti LJ, Zarzaur BL, Fischer PE, Williams RF, Myers AL, Bradburn EH, et al. Improved survival after hemostatic resuscitation: does the emperor have no clothes? J Trauma. 2011;70:97-102.
21. Lustenberger T, Frischknecht A, Brüesch M, Keel MJ. Blood component ratios in massively transfused blunt trauma patients a time-dependent covariate analysis. J Trauma. 2011;71:1144-50.
22. Brown JB, Cohen MJ, Minei JP, Maier RV, West MA, Billiar TR, et al. Inflammation and Host Response to Injury Investigators: Debunking the survival bias myth: characterization of mortality during the initial 24h for patients requiring massive transfusion. J Trauma Acute Care Surg. 2012;73:358-64.
23. Kudo D, Sasaki J, Akaishi S, Yamanouchi S, Koakutsu T, Endo T, et al. Efficacy of a high FFP:PRBC transfusion ratio on the survival of severely injured patients: a retrospective study in a single tertiary emergency center in Japan. Surg Today. 2014;44:653-61.
24. Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial. JAMA. 2015;313(5):471-82.
25. de Biasi AR, Stansbury LG, Dutton RP, Stein DM, Scalea TM, Hess JR. Blood product use in trauma resuscitation: plasma deficit versus plasma ratio as predictors of mortality in trauma (CME). Transfusion. 2011;51:1925-32.
26. Khan H, Belsher J, Yilmaz M, Afessa B, Winters JL, Moore SB, et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest. 2007;131:1308-14.