Massive bleeding and massive transfusion

Transfusion Medicine and Hemotherapy

Volumn 39, Issue 2, 2012, Pages 73-84

  Meißner, Andreas ^a   Schlenke, Peter ^b  

^a Schmerztherapie und Palliativmedizin Klinikum Stadt Soest   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Bleeding complication; Coagulation factors; Colloids; Erythrocyte transfusion; Fresh frozen plasma; Massive transfusion; Thrombocytes; Volume replacement

Indexed keywords

BLOOD CLOTTING FACTOR 13; BLOOD CLOTTING FACTOR 7A; BLOOD CLOTTING FACTOR 8; DESMOPRESSIN; FIBRINOGEN; FRESH FROZEN PLASMA; HETASTARCH; PADGEM PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TRANEXAMIC ACID;

ACIDOSIS; ANAEROBIC METABOLISM; BLEEDING; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BLOOD TRANSFUSION; CONTINUOUS INFUSION; CRYOPRECIPITATE; DISEASE SEVERITY; DISEASE TRANSMISSION; ENZYME ACTIVITY; ERYTHROCYTE TRANSFUSION; FIBRINOLYSIS; FLUID RESUSCITATION; HEALTH CARE ORGANIZATION; HOSPITAL ADMISSION; HUMAN; INJURY; INTENSIVE CARE; INTERNATIONAL NORMALIZED RATIO; META ANALYSIS (TOPIC); MORTALITY; PARTIAL THROMBOPLASTIN TIME; PATIENT MONITORING; PERIOPERATIVE PERIOD; PH; PROTEIN EXPRESSION; PROTHROMBIN TIME; REVIEW; SURVIVAL; THROMBOCYTE; TISSUE PERFUSION; VASCULARIZATION;

EID: 84859906995     PISSN: 16603796     EISSN: 16603818     Source Type: Journal    
DOI: 10.1159/000337250     Document Type: Review

References (96)

1. Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR: Blood transfusion rates in the care of acute trauma. Transfusion 2004;44:809-813. (Pubitemid 38738407)
2. Committee on Trauma ACoS: The Advanced Trauma Life Support Program, Instructors Manual. Chicago, American College of Surgeons, 1988, pp 59-62.
3. Theusinger OM, Spahn DR, Ganter MT: Transfusion in trauma: Why and how should we change our current practice? Curr Opin Anaesthesiol 2009;22: 305-312.
4. Thomas D, Wee M, Clyburn P, Walker I, Brohi K, Collins P, Doughty H, Isaac J, Mahoney PM, Shewry L: Blood transfusion and the anaesthetist: Management of massive haemorrhage. Anaesthesia 2010;65:1153-1161.
5. Deutsche Gesellschaft für Unfallchirurgie e.V. (DGU): S3 -Leitlinie Polytrauma/Schwerverletzten-Behandlung. Berlin, 2011. www.awmf.org/leitlinien/ detail/ll/012-019.html.
6. Bunn F, Trivedi D, Ashraf S: Colloid solutions for fluid resuscitation. Cochrane Database Syst Rev 2011;3:CD001319.
7. Garner J, Watts S, Parry C, Bird J, Cooper G, Kirkman E: Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage. Ann Surg 2010;251:1131-1139.
8. Hartog CS, Kohl M, Reinhart K: A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: Safety not adequately addressed. Anesth Analg 2011;112:635-645.
9. Westphal M, James MF, Kozek-Langenecker S, Stocker R, Guidet B, Van Aken H: Hydroxyethyl starches: Different products -different effects. Anesthesiology 2009;111:187-202.
10. Bickell WH, Wall MJ Jr., Pepe PE, Martin RR, Ginger VF, Allen MK, Mattox KL: Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994;331:1105-1109. (Pubitemid 24321214)
11. Holcomb JB: The 2004 Fitts Lecture: Current perspective on combat casualty care. J Trauma 2005;59:990-1002. (Pubitemid 43048723)
12. Li T, Zhu Y, Hu Y, Li L, Diao Y, Tang J, Liu L: Ideal permissive hypotension to resuscitate uncontrolled hemorrhagic shock and the tolerance time in rats. Anesthesiology 2011;114:111-119.
13. Stahel PF, Smith WR, Moore EE: Hypoxia and hypotension, the 'lethal duo' in traumatic brain injury: Implications for prehospital care. Intensive Care Med 2008;34:402-404. (Pubitemid 351623022)
14. Ganter MT, Pittet JF: New insights into acute coagulopathy in trauma patients. Best Pract Res Clin Anaesthesiol 2010;24:15-25.
15. Esmon CT: The protein C pathway. Chest 2003; 124(3 suppl):26S-32S. (Pubitemid 37128433)
16. Rezaie AR: Vitronectin functions as a cofactor for rapid inhibition of activated protein C by plasminogen activator inhibitor-1. Implications for the mechanism of profibrinolytic action of activated protein C. J Biol Chem 2001;276:15567-15570.
17. Brohi K, Cohen MJ, Ganter MT, Schultz MJ, Levi M, Mackersie RC, Pittet JF: Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma 2008;64:1211-1217. (Pubitemid 351671214)
18. Cotton BA, Gunter OL, Isbell J, Au BK, Robertson AM, Morris JA Jr., St Jacques P, Young PP: Damage control hematology: The impact of a trauma exsanguination protocol on survival and blood product utilization. J Trauma 2008;64:1177-1182. (Pubitemid 351671208)
19. Djaldetti M, Fishman P, Bessler H, Chaimoff C: PH-induced platelet ultrastructural alterations. A possible mechanism for impaired platelet aggregation. Arch Surg 1979;114:707-710. (Pubitemid 9228857)
20. Martini WZ: Coagulopathy by hypothermia and acidosis: Mechanisms of thrombin generation and fibrinogen availability. J Trauma 2009;67:202-208.
21. Zander R: Anaemia and massive bleeding apart from the aspect of oxygenation. Wien Klin Wochenschr 2010;122(suppl 5):S6-8.
22. Furie B, Furie BC: Thrombus formation in vivo. J Clin Invest 2005;115:3355-3362. (Pubitemid 43121819)
23. Lier H, Krep H, Schroeder S, Stuber F: Preconditions of hemostasis in trauma: A review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 2008;65:951-960.
24. Zander R: Association between plasma ionized calcium and lactate concentration. Intensive Care Med 1993;19:362-363.
25. Vivien B, Langeron O, Morell E, Devilliers C, Carli PA, Coriat P, Riou B: Early hypocalcemia in severe trauma. Crit Care Med 2005;33:1946-1952. (Pubitemid 41306514)
26. Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A: Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. Lancet 1996;347:289-292. (Pubitemid 26041040)
27. Watts DD, Trask A, Soeken K, Perdue P, Dols S, Kaufmann C: Hypothermic coagulopathy in trauma: Effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity. J Trauma 1998;44:846-854. (Pubitemid 28233032)
28. Wolberg AS, Meng ZH, Monroe DM 3rd, Hoffman M: A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004;56:1221-1228. (Pubitemid 38901832)
29. Dirkmann D, Hanke AA, Gorlinger K, Peters J: Hypothermia and acidosis synergistically impair coagulation in human whole blood. Anesth Analg 2008;106:1627-1632.
30. Meng ZH, Wolberg AS, Monroe DM 3rd, Hoffman M: The effect of temperature and pH on the activity of factor VIIa: Implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients. J Trauma 2003;55:886-891. (Pubitemid 38004660)
31. Keller-Stanislawski B, Lohmann A, Gunay S, Heiden M, Funk MB: The German Haemovigilance System -reports of serious adverse transfusion reactions between 1997 and 2007. Transfus Med 2009;19:340-349.
32. Silliman CC, Fung YL, Ball JB, Khan SY: Transfusion-related acute lung injury (TRALI): Current concepts and misconceptions. Blood Rev 2009;23: 245-255.
33. Peiniger S, Nienaber U, Lefering R, Braun M, Wafaisade A, Wutzler S, Borgmann M, Spinella PC, Maegele M: Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury. Crit Care 2011;15:R68.
34. Borgman MA, Spinella PC, Holcomb JB, Blackbourne LH, Wade CE, Lefering R, Bouillon B, Maegele M: The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang 2011;101: 44-54.
35. Maegele M, Lefering R, Paffrath T, Tjardes T, Simanski C, Bouillon B: Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: A retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 2008;95:112-119. (Pubitemid 351951900)
36. Ho AM, Dion PW, Cheng CA, Karmakar MK, Cheng G, Peng Z, Ng YW: A mathematical model for fresh frozen plasma transfusion strategies during major trauma resuscitation with ongoing hemorrhage. Can J Surg 2005;48:470-478. (Pubitemid 43117097)
37. Hiippala ST, Myllyla GJ, Vahtera EM: Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesth Analg 1995;81:360-365.
38. Spahn DR, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Gordini G, Stahel PF, Hunt BJ, Komadina R, Neugebauer E, Ozier Y, Riddez L, Schultz A, Vincent JL, Rossaint R: Management of bleeding following major trauma: A European guideline. Crit Care 2007;11:R17.
39. Hiippala ST: Dextran and hydroxyethyl starch interfere with fibrinogen assays. Blood Coagul Fibrinolysis 1995;6:743-746. (Pubitemid 26047204)
40. Singbartl K, Innerhofer P, Radvan J, Westphalen B, Fries D, Stogbauer R, Van Aken H: Hemostasis and hemodilution: A quantitative mathematical guide for clinical practice. Anesth Analg 2003;96:929-935. (Pubitemid 36359018)
41. Meyer MA, Ostrowski SR, Windelov NA, Johansson PI: Fibrinogen concentrates for bleeding trauma patients: What is the evidence? Vox Sang 2011;101:185-190.
42. Stinger HK, Spinella PC, Perkins JG, Grathwohl KW, Salinas J, Martini WZ, Hess JR, Dubick MA, Simon CD, Beekley AC, Wolf SE, Wade CE, Holcomb JB: The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital. J Trauma 2008;64(2 suppl):S79-85.
43. Blome M, Isgro F, Kiessling AH, Skuras J, Haubelt H, Hellstern P, Saggau W: Relationship between factor XIII activity, fibrinogen, haemostasis screening tests and postoperative bleeding in cardiopulmonary bypass surgery. Thromb Haemost 2005;93: 1101-1107. (Pubitemid 40823515)
44. Charbit B, Mandelbrot L, Samain E, Baron G, Haddaoui B, Keita H, Sibony O, Mahieu-Caputo D, Hurtaud-Roux MF, Huisse MG, Denninger MH, de Prost D: The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. J Thromb Haemost 2007;5:266-273. (Pubitemid 46139450)
45. Huissoud C, Carrabin N, Audibert F, Levrat A, Massignon D, Berland M, Rudigoz RC: Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry. BJOG 2009;116: 1097-1102.
46. Tian HL, Chen H, Wu BS, Cao HL, Xu T, Hu J, Wang G, Gao WW, Lin ZK, Chen SW: D-dimer as a predictor of progressive hemorrhagic injury in patients with traumatic brain injury: Analysis of 194 cases. Neurosurg Rev 2010;33:359-365.
47. Rossaint R, Bouillon B, Cerny V, Coats TJ, Duranteau J, Fernandez-Mondejar E, Hunt BJ, Komadina R, Nardi G, Neugebauer E, Ozier Y, Riddez L, Schultz A, Stahel PF, Vincent JL, Spahn DR: Management of bleeding following major trauma: An updated European guideline. Crit Care 2010;14:R52.
48. Procoagulators. Transfus Med Hemother 2009; 36:419-436.
49. Callum JL, Karkouti K, Lin Y: Cryoprecipitate: The current state of knowledge. Transfus Med Rev 2009;23:177-88.
50. Bolliger D, Gorlinger K, Tanaka KA: Pathophysiology and treatment of coagulopathy in massive hemorrhage and hemodilution. Anesthesiology 2010;113:1205-1219.
51. Sorensen B, Bevan D: A critical evaluation of cryoprecipitate for replacement of fibrinogen. Br J Haematol 2010;149:834-843.
52. Levy JH, Tanaka KA, Dietrich W: Perioperative hemostatic management of patients treated with vitamin K antagonists. Anesthesiology 2008;109:918-926.
53. Dickneite G, Doerr B, Kaspereit F: Characterization of the coagulation deficit in porcine dilutional coagulopathy and substitution with a prothrombin complex concentrate. Anesth Analg 2008;106:1070-1077. (Pubitemid 351450528)
54. Dickneite G, Dorr B, Kaspereit F, Tanaka KA: Prothrombin complex concentrate versus recombinant factor VIIa for reversal of hemodilutional coagulopathy in a porcine trauma model. J Trauma 2010;68:1151-1157.
55. Tanaka KA, Szlam F, Dickneite G, Levy JH: Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulation. Thromb Res 2008;122:117-123. (Pubitemid 351601847)
56. Dusel CH, Grundmann C, Eich S, Seitz R, Konig H: Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates. Blood Coagul Fibrinolysis 2004;15:405-411. (Pubitemid 38901611)
57. Leissinger CA, Blatt PM, Hoots WK, Ewenstein B: Role of prothrombin complex concentrates in reversing warfarin anticoagulation: A review of the literature. Am J Hematol 2008;83:137-143.
58. Tien HC, Gough MR, Farrell R, Macdonald J: Successful use of recombinant activated coagulation factor VII in a patient with massive hemoptysis from a penetrating thoracic injury. Ann Thorac Surg 2007;84:1373-1374. (Pubitemid 47432649)
59. Ranucci M, Isgro G, Soro G, Conti D, De Toffol B: Efficacy and safety of recombinant activated factor VII in major surgical procedures: Systematic review and meta-analysis of randomized clinical trials. Arch Surg 2008;143:296-304. (Pubitemid 351439290)
60. Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet 1999;354:1879.
61. Mitra B, Cameron PA, Parr MJ, Phillips L: Recombinant factor VIIa in trauma patients with the 'triad of death'. Injury 2011; DOI: 10.1016/j.injury. 2011.01.033.
62. Levi M, Levy JH, Andersen HF, Truloff D: Safety of recombinant activated factor VII in randomized clinical trials. N Engl J Med 2010;363:1791-1800.
63. Spinella PC, Perkins JG, McLaughlin DF, Niles SE, Grathwohl KW, Beekley AC, Salinas J, Mehta S, Wade CE, Holcomb JB: The effect of recombinant activated factor VII on mortality in combatrelated casualties with severe trauma and massive transfusion. J Trauma 2008;64:286-293; discussion 293-294. (Pubitemid 351640428)
64. Ferraris VA, Brown JR, Despotis GJ, Hammon JW, Reece TB, Saha SP, Song HK, Clough ER, Shore-Lesserson LJ, Goodnough LT, Mazer CD, Shander A, Stafford-Smith M, Waters J, Baker RA, Dickinson TA, FitzGerald DJ, Likosky DS, Shann KG: 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg 2011;91:944-982.
65. Knudson MM, Cohen MJ, Reidy R, Jaeger S, Bacchetti P, Jin C, Wade CE, Holcomb JB: Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma Association. J Am Coll Surg 2011;212:87-95.
66. Korte W: F. XIII in perioperative coagulation management. Best Pract Res Clin Anaesthesiol 2010;24:85-93.
67. Mittermayr M, Streif W, Haas T, Fries D, Velik-Salchner C, Klingler A, Oswald E, Bach C, Schnapka-Koepf M, Innerhofer P: Hemostatic changes after crystalloid or colloid fluid administration during major orthopedic surgery: The role of fibrinogen administration. Anesth Analg 2007;105: 905-917. (Pubitemid 47479300)
68. Marti-Fabregas J, Borrell M, Silva Y, Delgado-Mederos R, Martinez-Ramirez S, de Juan-Delago M, Tirado I, Alejaldre A, Marin R, Marti-Vilalta JL, Fontcuberta J: Hemostatic proteins and their association with hematoma growth in patients with acute intracerebral hemorrhage. Stroke 2010;41:2976-2978.
69. Potzsch B, Ivaskevicius V: Haemostasis management of massive bleeding. Hamostaseologie 2011; 31:15-20.
70. Fergusson DA, Hebert PC, Mazer CD, Fremes S, MacAdams C, Murkin JM, Teoh K, Duke PC, Arellano R, Blajchman MA, Bussieres JS, Cote D, Karski J, Martineau R, Robblee JA, Rodger M, Wells G, Clinch J, Pretorius R: A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med 2008;358:2319-2331. (Pubitemid 351749156)
71. Shaw AD, Stafford-Smith M, White WD, Phillips-Bute B, Swaminathan M, Milano C, Welsby IJ, Aronson S, Mathew JP, Peterson ED, Newman MF: The effect of aprotinin on outcome after coronary-artery bypass grafting. N Engl J Med 2008;358:784-793. (Pubitemid 351284456)
72. Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejia-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S: Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2010;376:23-32.
73. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W: Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: A systematic review of randomized trials. Thromb Res 2009;123:687-696.
74. Carless PA, Henry DA, Moxey AJ, O'Connell D, McClelland B, Henderson KM, Sly K, Laupacis A, Fergusson D: Desmopressin for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2004:CD001884.
75. Barletta JF, Cooper B, Ohlinger MJ: Adverse drug events associated with disorders of coagulation. Crit Care Med 2010;38(6 suppl):S198-218.
76. Crescenzi G, Landoni G, Biondi-Zoccai G, Pappalardo F, Nuzzi M, Bignami E, Fochi O, Maj G, Calabro MG, Ranucci M, Zangrillo A: Desmopressin reduces transfusion needs after surgery: A metaanalysis of randomized clinical trials. Anesthesiology 2008;109:1063-1076.
77. Afshari A, Wikkelso A, Brok J, Moller AM, Wetterslev J: Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion. Cochrane Database Syst Rev 2011;3:CD007871.
78. Johansson PI, Stensballe J: Hemostatic resuscitation for massive bleeding: The paradigm of plasma and platelets -a review of the current literature. Transfusion 2010;50:701-710.
79. Carless PA, Henry DA, Carson JL, Hebert PP, Mc-Clelland B, Ker K: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev 2010: CD002042.
80. Kaufman R: A fresh take on whole blood. Transfusion 2011;51:230-233.
81. Uijttewaal WS, Nijhof EJ, Bronkhorst PJ, Den Hartog E, Heethaar RM: Near-wall excess of platelets induced by lateral migration of erythrocytes in flowing blood. Am J Physiol 1993;264:H1239-1244. (Pubitemid 23115299)
82. Valles J, Santos MT, Aznar J, Martinez M, Moscardo A, Pinon M, Broekman MJ, Marcus AJ: Platelet-erythrocyte interactions enhance alpha(IIb) beta(3) integrin receptor activation and P-selectin expression during platelet recruitment: Down-regulation by aspirin ex vivo. Blood 2002;99:3978-3984. (Pubitemid 35332037)
83. AlMomani T, Udaykumar HS, Marshall JS, Chandran KB: Micro-scale dynamic simulation of erythrocyte-platelet interaction in blood flow. Ann Biomed Eng 2008;36:905-920.
84. Hardy JF, de Moerloose P, Samama CM: Massive transfusion and coagulopathy: Pathophysiology and implications for clinical management. Can J Anaesth 2006;53(6 suppl):S40-58. (Pubitemid 44150884)
85. Spinella PC, Perkins JG, Grathwohl KW, Repine T, Beekley AC, Sebesta J, Jenkins D, Azarow K, Holcomb JB: Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital. World J Surg 2008;32:2-6. (Pubitemid 50001733)
86. Spinella PC, Perkins JG, Grathwohl KW, Beekley AC, Holcomb JB: Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries. J Trauma 2009(4 suppl);66:S69-76.
87. Perkins JG, Cap AP, Spinella PC, Shorr AF, Beekley AC, Grathwohl KW, Rentas FJ, Wade CE, Holcomb JB: Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME). Transfusion 2011;51:242-252.
88. Ho KM, Leonard AD: Lack of effect of unrefrigerated young whole blood transfusion on patient outcomes after massive transfusion in a civilian setting. Transfusion 2011;51:1669-1675.
89. Teixeira PG, Inaba K, Shulman I, Salim A, Demetriades D, Brown C, Browder T, Green D, Rhee P: Impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009;66:693-69.
90. Yucel N, Lefering R, Maegele M, Vorweg M, Tjardes T, Ruchholtz S, Neugebauer EA, Wappler F, Bouillon B, Rixen D: Trauma Associated Severe Hemorrhage (TASH)-Score: Probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma 2006;60:1228-1236.
91. Hirshberg A, Dugas M, Banez EI, Scott BG, Wall MJ Jr., Mattox KL: Minimizing dilutional coagulopathy in exsanguinating hemorrhage: A computer simulation. J Trauma 2003;54:454-463. (Pubitemid 36383741)
92. Holcomb JB, Wade CE, Michalek JE, Chisholm GB, Zarzabal LA, Schreiber MA, Gonzalez EA, Pomper GJ, Perkins JG, Spinella PC, Williams KL, Park MS: Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 2008;248:447-458.
93. Miller RD: Massive blood transfusions: The impact of Vietnam military data on modern civilian transfusion medicine. Anesthesiology 2009;110:1412-1416.
94. Leslie SD, Toy PT: Laboratory hemostatic abnormalities in massively transfused patients given red blood cells and crystalloid. Am J Clin Pathol 1991;96:770-773.
95. Johansson PI, Stensballe J, Rosenberg I, Hilslov TL, Jorgensen L, Secher NH: Proactive administration of platelets and plasma for patients with a ruptured abdominal aortic aneurysm: Evaluating a change in transfusion practice. Transfusion 2007;47:593-598. (Pubitemid 46449619)
96. Lecompte T, Hardy JF: Antiplatelet agents and perioperative bleeding. Can J Anaesth 2006;53 (6 suppl):S103-112. (Pubitemid 44150888)