In silico structure-based design and synthesis of novel anti-RSV compounds

Antiviral Research

Volumn 122, Issue , 2015, Pages 46-50

  Cancellieri, Michela ^a   Bassetto, Marcella ^a   Widjaja, Ivy ^b   Van Kuppeveld, Frank ^b   De Haan, Cornelis A M ^b   Brancale, Andrea ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Antiviral; Respiratory syncytial virus; Structure based virtual screening; Zinc ejecting compounds

Indexed keywords

ANTIVIRUS AGENT; DITHIOCARBAMIC ACID; PIPERAZINE DERIVATIVE; PROTEIN M2; PROTEIN M2-1; UNCLASSIFIED DRUG; ZINC DERIVATIVE; ZINC ION; N,N' ETHYLENEBIS(DITHIOCARBAMIC ACID) DERIVATIVE; VIRUS PROTEIN; ZINC; ZINC FINGER PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; COMPUTER AIDED DESIGN; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN RESPIRATORY SYNCYTIAL VIRUS; IC50; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION; ZINC FINGER MOTIF; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; SYNTHESIS; TUMOR CELL LINE;

RESPIRATORY SYNCYTIAL VIRUS; RICE STRIPE VIRUS;

ANTIVIRAL AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; DRUG DESIGN; ETHYLENEBIS(DITHIOCARBAMATES); HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; VIRAL PROTEINS; VIRUS REPLICATION; ZINC; ZINC FINGERS;

EID: 84939138083     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2015.08.003     Document Type: Article

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