Macrophage repolarization with targeted alginate nanoparticles containing IL-10 plasmid DNA for the treatment of experimental arthritis

Biomaterials

Volumn 61, Issue , 2015, Pages 162-177

  Jain, Shardool ^a   Tran, Thanh Huyen ^a   Amiji, Mansoor ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Alginate nanoparticles; IL 10 gene therapy; Inflammation; Macrophage repolarization; Rheumatoid arthritis; Targeted delivery

Indexed keywords

ALGINATE; ANIMALS; BIOMOLECULES; DNA; GENE THERAPY; GENES; MACROPHAGES; MAGNETIC RESONANCE IMAGING; NANOPARTICLES; PATHOLOGY; RATS;

CHRONIC INFLAMMATORY DISEASE; INFLAMMATION; INTRAPERITONEAL ADMINISTRATION; MACROPHAGE PHENOTYPES; PRO-INFLAMMATORY CYTOKINES; REPOLARIZATION; RHEUMATOID ARTHRITIS; TARGETED DELIVERY;

DISEASES;

ALGINATE NANOPARTICLE; ALGINIC ACID; CD163 ANTIGEN; INDOCYANINE GREEN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; NANOCARRIER; PLASMID DNA; TUFTSIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; GLUCURONIC ACID; HEXURONIC ACID; NANOCAPSULE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROSS LINKING; EXPERIMENTAL ARTHRITIS; GENE THERAPY; GENETIC TRANSFECTION; IMMUNE RESPONSE; LIVER HISTOLOGY; MACROPHAGE; MALE; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOCLAST ACTIVITY; OSTEOLYSIS; PARTICLE SIZE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RANDOMIZED CONTROLLED TRIAL; RAT; RELAXATION TIME; REPOLARIZATION; UPREGULATION; WATER CONTENT; WEIGHT CHANGE; ADMINISTRATION AND DOSAGE; ANIMAL; ARTHRITIS; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; LEWIS RAT; PATHOLOGY; PLASMID; PROCEDURES; TREATMENT OUTCOME; ULTRASTRUCTURE;

ANIMALIA; RATTUS;

ALGINATES; ANIMALS; ARTHRITIS; CYTOKINES; GLUCURONIC ACID; HEXURONIC ACIDS; INTERLEUKIN-10; MACROPHAGES; MALE; NANOCAPSULES; PLASMIDS; RATS; RATS, INBRED LEW; TRANSFECTION; TREATMENT OUTCOME;

EID: 84939133128     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.05.028     Document Type: Article

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