Effect of electroacupuncture on P2X3 receptor regulation in the peripheral and central nervous systems of rats with visceral pain caused by irritable bowel syndrome

Purinergic Signalling

Volumn 11, Issue 3, 2015, Pages 321-329

  Weng, Z J ^a   Wu, L Y ^b   Zhou, C L ^a   Dou, C Z ^a   Shi, Y ^a   Liu, H R ^a   Wu, H G ^a  

^a SHANGHAI RESEARCH INSTITUTE OF ACUPUNCTURE AND MERIDIAN   (China)

^b Shanghai Qigong Institute   (China)

Author keywords

Brain gut axis; Electroacupuncture; Irritable bowel syndrome; P2X3; Visceral pain

Indexed keywords

MESSENGER RNA; NEUROTRANSMITTER RECEPTOR; PURINERGIC P2X3 RECEPTOR;

ANIMAL MODEL; ANTERIOR CINGULATE; ARTICLE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; ELECTROACUPUNCTURE; HYPERALGESIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IRRITABLE COLON; MALE; MYENTERIC PLEXUS; NEWBORN; NOCICEPTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; RAT; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR DOWN REGULATION; SPINAL CORD; SPINAL GANGLION; VISCERAL PAIN; WITHDRAWAL REFLEX; ACUPUNCTURE; ANIMAL; BIOSYNTHESIS; COMPLICATION; DOWN REGULATION; GENETICS; INTESTINE INNERVATION; PAIN MEASUREMENT; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACUPUNCTURE POINTS; ANIMALS; ANIMALS, NEWBORN; CENTRAL NERVOUS SYSTEM; DOWN-REGULATION; ELECTROACUPUNCTURE; ENTERIC NERVOUS SYSTEM; IRRITABLE BOWEL SYNDROME; MALE; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X3; RNA, MESSENGER; VISCERAL PAIN;

EID: 84938992240     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-015-9447-6     Document Type: Article

References (43)

1. O’Mahony L, McCarthy J, Kelly P et al (2005) Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128(3):541–551
2. Kim DY, Camilleri M (2000) Serotonin: a mediator of the brain-gut connection. Am J Gastroenterol 95(10):2698–2709
3. Fukudo S, Nomura T, Muranaka M et al (1993) Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study. J Clin Gastroenterol 17(2):133–141
4. Burnstock G, Kennedy C (2011) P2X receptors in health and disease. Adv Pharmacol 61:333–372
5. Burnstock G (2014) Purinergic signalling in the gastrointestinal tract and related organs in health and disease. Purinergic Signal 10(1):3–50
6. Burnstock G (2014) Purinergic signalling in the urinary tract in health and disease. Purinergic Signal 10(1):103–155. doi:10.1007/s11302-013-9395-y, Epub 2013 Nov 22
7. Burnstock G (2013) Purinergic signalling: pathophysiology and therapeutic potential. Keio J Med 62(3):63–73
8. Ochoa-Cortes F, Liñán-Rico A, Jacobson KA et al (2014) Potential for developing purinergic drugs for gastrointestinal diseases. Inflamm Bowel Dis 20(7):1259–1287. doi:10.1097/MIB.0000000000000047
9. Zhou EH, Ding GH, Wu HG, Qi L, Liu HR, Wang XM, Ma XP (2011) Immediate effect of acupuncture on colon motility in patients with irritable bowel syndrome. Zhonghua Zhongyiyao Xuekan 29:293–296
10. Ma XP (2014) Acupuncture-moxibustion in treating irritable bowel syndrome: how does it work? World J Gastroenterol 20(20):6044–6054
11. Ji J, Lu Y, Liu H et al (2013) Acupuncture and moxibustion for inflammatory bowel diseases: a systematic review and meta-analysis of randomized controlled trials. Evid Based Complement Alternat Med 2013:158352. doi:10.1155/2013/158352, Epub 2013 Sep 24
12. Wu HG, Jiang B, Zhou EH et al (2008) Regulatory mechanism of electroacupuncture in irritable bowel syndrome: preventing MC activation and decreasing SP VIP secretion. Dig Dis Sci 53(6):1644–1651
13. Liu HR, Wang XM, Zhou EH et al (2009) Acupuncture at both ST25 and ST37 improves the pain threshold of chronic visceral hypersensitivity rats. Neurochem Res 34(11):1914–1918
14. Huang RJ, Zhao JM, Wu LY et al (2014) Mechanisms underlying the analgesic effect of moxibustion on visceral pain in irritable bowel syndrome: a review. Evid Based Complement Alternat Med 2014:895914. doi:10.1155/2014/895914, Epub 2014 Jul 1
15. Burnstock G (2008) The journey to establish purinergic signalling in the gut. Neurogastroenterol Motil 20(Suppl 1):8–19
16. 3 receptors shaping pain signaling. Front Cell Neurosci 7:245
17. Burnstock G (2013) Introduction and perspective, historical note. Front Cell Neurosci 7:227
18. Xu GY, Shenoy M, Winston JH et al (2008) P2X receptor-mediated visceral hyperalgesia in a rat model of chronic visceral hypersensitivity. Gut 57(9):1230–1237
19. Soares-Bezerra RJ, Calheiros AS, da Silva Ferreira NC et al (2013) Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors. Pharmaceuticals (Basel) 6(5):650–658
20. Burnstock G, Nistri A, Khakh BS et al (2014) ATP-gated P2X receptors in health and disease. Front Cell Neurosci 8:204
21. Scalera A, Loguercio C (2012) Focus on irritable bowel syndrome. Eur Rev Med Pharmacol Sci 16(9):1155–1171
22. 3 receptor in rats with chronic neuropathic pain states. J Neurosci Res 92(12):1703–1713
23. Burnstock G (2011) Puncturing the myth-purinergic signaling, not mystical energy, may explain how acupuncture works. The Scientist
24. Al-Chaer ED, Kawasaki M, Pasricha PJ (2000) A new model of chronic visceral hypersensitivity in adult rats induced by colon irritation during postnatal development. Gastroenterology 119(5):1276–1285
25. Rong W, Spyer KM, Burnstock G (2002) Activation and sensitisation of low and high threshold afferent fibers mediated by P2X receptors in the mouse urinary bladder. J Physiol 541(Pt 2):591–600
26. Burnstock G (2001) Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci 22(4):182–188
27. Shinoda M, Feng B, Gebhart GF (2009) Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology 137(6):2096–2104
28. Tamir H, Gershon MD (1990) Serotonin-storing secretory vesicles. Ann N Y Acad Sci 600:53–66
29. Accarino AM, Azpiroz F, Malagelada JR (1997) Attention and distraction: effects on gut perception. Gastroenterology 113(2):415–422
30. Shinoda M, La JH, Bielefeldt K, Gebhart GF (2010) Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity. J Neurophysiol 104(6):3113–3123
31. 3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity. Neural Regen Res 8(9):802–808
32. North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82(4):1013–1067
33. Xu KD, Liang T, Wang K et al (2010) Effect of pre-electroacupuncture on p38 and c-Fos expression in the spinal dorsal horn of rats suffering from visceral pain. Chin Med J (Engl) 123(9):1176–1181
34. Yu WC, Huang GY, Zhang MM et al (2008) Effect of connexin 43 knockout on acupuncture-induced down-regulation of c-fos expression in spinal dorsal horn in visceral pain mice. Acupunct Res 33(3):179–182
35. 2,3 receptor and c-fos of rats with irritable bowel syndrome visceral sensitivity. Shang Hai University of T.C.M. Master thesis
36. Gibney SM, Gosselin RD, Dinan TG et al (2010) Colorectal distension-induced prefrontal cortex activation in the Wistar-Kyoto rat: implications for irritable bowel syndrome. Neuroscience 165(3):675–683
37. Elsenbruch S (2011) Abdominal pain in irritable bowel syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun 25(3):386–394. doi:10.1016/j.bbi.2010.11.010, Epub 2010 Nov 20
38. Shyu BC, Sikes RW, Vogt LJ, Vogt BA (2010) Nociceptive processing by anterior cingulate pyramidal neurons. J Neurophysiol 103(6):3287–3301
39. Yan N, Cao B, Xu J et al (2012) Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats. Neurobiol Learn Mem 97(1):156–164
40. Sikes RW, Vogt LJ, Vogt BA (2008) Distribution and properties of visceral nociceptive neurons in rabbit cingulate cortex. Pain 135(1–2):160–174
41. Naliboff BD, Berman S, Suyenobu B et al (2006) Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology 131(2):352–365
42. Burnstock G (2015) Physiopathological roles of P2X receptors in the central nervous system. Curr Med Chem 22(7):819–844
43. Wang J, Zhang X, Cao B, et al. (2013) Facilitation of synaptic transmission in the anterior cingulate cortex in viscerally hypersensitive rats. Cereb Cortex. [Epub ahead of print]