Effect of pre-electroacupuncture on p38 and c-Fos expression in the spinal dorsal horn of rats suffering from visceral pain

Chinese Medical Journal

Volumn 123, Issue 9, 2010, Pages 1176-1181

  Xu, Ke Da ^a   Liang, Tao ^b   Wang, Kun ^c   Tian, De An ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Analgesic; Electroacupuncture; Mitogen activated protein kinase; Spinal dorsal horn; Visceral pain

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ELECTROACUPUNCTURE; ELECTROANALGESIA; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; INTESTINE WALL; MALE; NONHUMAN; PAIN ASSESSMENT; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; VISCERAL PAIN;

ACUPUNCTURE POINTS; ANIMALS; BLOTTING, WESTERN; ELECTROACUPUNCTURE; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN; POLYMERASE CHAIN REACTION; POSTERIOR HORN CELLS; PROTO-ONCOGENE PROTEINS C-FOS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; VISCERA;

EID: 77952390496     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2010.09.014     Document Type: Article

References (21)

1. Sweatt JD. The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory. J Neurochem 2001; 76: 1-10.
2. Shen CP, Tsimberg Y, Salvadore C, Meller E. Activation of Erk and JNK MAPK pathways by acute swim stress in rat brain regions. BMC Neurosci 2004; 5: 36.
3. Meller E, Shen C, Nikolao TA, Jensen C, Tsimberg Y, Chen J, et al. Region-specific effects of acute and repeated restraint stress on the phosphorylation of mitogen-activated protein kinases. Brain Res 2003; 979: 57-64.
4. Cruz CD, Neto FL, Castro-Lopes J. Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats. Pain 2005; 116: 411-419.
5. Wang K, Wu H, Wang G, Li M, Zhang Z, Gu G. The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats. Anesth Analg 2009; 109: 1666-1673.
6. Tian XY, Bian ZX, Hu XG, Zhang XJ, Liu L, Zhang H. Electroacupuncture attenuates stress induced defecation in rats with chronic visceral hypersensitivity via serotonergic pathway. Brain Res 2006; 1088: 101-108.
7. Miampamba M, Chery-Croze S, Gorry F. Inflammation of the colonic wall induced by formalin as a model of acute visceral pain. Pain 1994; 57: 327-334.
8. Cao LQ, Wang T. The change of the concentration of substance P in the rats "channel" "point" skin and plasma in the acupuncture analgesia. Acupunct Res (Chin) 1989; 14: 452-462.
9. Lee HJ, Lee JH, Lee EO, Lee HJ, Kim KH, Lee KS, et al. Substance P and beta endorphin mediate electroacupuncture induced analgesic activity in mouse cancer pain model. Acupunct Electrother Res 2009; 34: 27-40.
10. Liu JH, Yan J, Yi SX, Chang XR, Lin YP, Hu JM. Effects of electroacupuncture on gastric myoelectro activity and substance P in the dorsal vagal complex of rats. Neurosci Lett 2004; 356: 99-102.
11. Shen S, Bian JT, Tian JB, Han JS. Frequency dependence of substance P release by electroacupuncture in rat spinal cord. Acta Physiol Sin (Chin) 1996; 48: 89-93.
12. Li YM, Zhuang LX, Lai XS, Jiang GH. Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients. Acupunct Res (Chin) 2007; 32: 136-138.
13. Ji RR, Gereau RW 4th, Malcangio M, Strichartz GR. MAP kinase and pain. Brain Res Rev 2009; 60: 135-148.
14. Zhang Y, Gu EW, Zhang J, Chen ZW. Role of p38 mitogen-activated protein kinases in cardioprotection of morphine preconditioning. Chin Med J 2007; 120: 777-781.
15. Wen YR, Suter MR, Ji RR, Yeh GC, Wu YS, Wang KC, et al. Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology 2009; 110: 155-165.
16. Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999; 2: 1114-1119.
17. Yu WC, Huang GY, Zhang MM, Wang W. Effect of connexin 43 knockout on acupuncture-induced down-regulation of c-fos expression in spinal dorsal horn in visceral pain mice. Acupunct Res (Chin) 2008; 33: 179-182.
18. Grewal SS, York RD, Stork PJ. Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 1999; 9: 544-553.
19. Zhou B, Wang ZX, Zhao Y, Brautigan DL, Zhang ZY. The specificity of extracellular signal-regulated kinase2 dephosphorylation by protein phosphatases. J Biol Chem 2002; 277: 31818-31825.
20. Lao L, Zhang RX, Zhang G, Wang X, Berman BM, Ren K. A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats. Brain Res 2004; 1020: 18-29.
21. Li A, Wang Y, Xin J, Lao L, Ren K, Berman BM, et al. Electroacupuncture suppresses hyperalgesia and spinal Fos expression by activating the descending inhibitory system. Brain Res 2007; 1186: 171-179.