Metabolism of Classical Cannabinoids and the Synthetic Cannabinoid JWH-018

Clinical Pharmacology and Therapeutics

Volumn 97, Issue 6, 2015, Pages 562-564

  Su, M K ^a   Seely, K A ^b   Moran, J H ^b,c   Hoffman, R S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARKANSAS DEPARTMENT OF HEALTH   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (1 NAPHTHOYL) 1 PENTYLINDOLE; CANNABINOID 1 RECEPTOR; CANNABIS; CYTOCHROME P450 1A2; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DRONABINOL; 1-PENTYL-3-(1-NAPHTHOYL)INDOLE; CANNABINOID; GLUCURONOSYLTRANSFERASE; INDOLE DERIVATIVE; NAPHTHALENE DERIVATIVE; UDP-GLUCURONOSYLTRANSFERASE, UGT1A3;

ARTICLE; DRUG METABOLISM; DRUG RECEPTOR BINDING; GENE EXPRESSION; PRIORITY JOURNAL; RACE DIFFERENCE; DRUG EFFECTS; HUMAN; METABOLISM; PHYSIOLOGY;

CANNABINOIDS; CYTOCHROME P-450 CYP2D6; DRONABINOL; GLUCURONOSYLTRANSFERASE; HUMANS; INDOLES; NAPHTHALENES; RECEPTOR, CANNABINOID, CB1;

EID: 84938948545     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1002/cpt.114     Document Type: Article

References (5)

1. Seely, K.A., Lapoint, J., Moran, J.H. & Fattore, L. Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids. Prog. Neuropsychopharmacol. Biol. Psychiatry 39, 234-243 (2012).
2. Fantegrossi, W.E., Moran, J.H., Radominska-Pandya, A. & Prather, P.L. Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to D(9)-THC: Mechanism underlying greater toxicity? Life Sci. 97, 45-54 (2014).
3. Chimalakonda, K.C. et al. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: Identification of novel cannabinoid receptor ligands. Drug Metab. Dispos. 40, 2174-2184 (2012).
4. Zhou, S.F., Liu, J.P. & Chowbay, B. Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metab. Rev. 41, 89-295 (2009).
5. Chimalakonda, K.C. et al. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDPglucuronosyltransferases. Drug Metab. Dispos. 39, 1967-1976 (2011).