Efficient method to optimize antibodies using avian leukosis virus display and eukaryotic cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 32, 2015, Pages 9860-9865

  Yu, Changming ^a,b   Pike, Gennett M ^a   Rinkoski, Tommy A ^a   Correia, Cristina ^a   Kaufmann, Scott H ^a   Federspiel, Mark J ^a   Weiss, Robin A ^c  

^a MAYO CLINIC   (United States)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antibody binding affinity; Antibody engineering; Avian leukosis virus; Avian leukosis virus polypeptide display; Protein display technology

Indexed keywords

ALKALINE PHOSPHATASE; ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; LAMININ; POLYPEPTIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VIRUS FUSION PROTEIN; COMPLEMENTARITY DETERMINING REGION; GLYCOPROTEIN; HYBRID PROTEIN; MUTANT PROTEIN; PROTEIN BINDING; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY ENGINEERING; ANTIBODY LIBRARY; ANTIBODY PRODUCTION; ARTICLE; AVIAN LEUKOSIS VIRUS; BINDING AFFINITY; BINDING KINETICS; BIOTINYLATION; CELL SURFACE; CHICKEN; CODON; COMPLEMENTARITY DETERMINING REGION; EUKARYOTIC CELL; GENE EXPRESSION; GENE EXPRESSION SYSTEM; GENETIC CODE; IMMUNOBLOTTING; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPORTER GENE; SITE DIRECTED MUTAGENESIS; SOMATIC HYPERMUTATION; SURFACE PLASMON RESONANCE; VIRUS REPLICATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL SURFACE DISPLAY; CHEMISTRY; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PROCEDURES; VIRION;

AVIAN LEUKOSIS VIRUS; EUKARYOTA; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; AVIAN LEUKOSIS VIRUS; CELL LINE; CELL SURFACE DISPLAY TECHNIQUES; CHICKENS; COMPLEMENTARITY DETERMINING REGIONS; EUKARYOTIC CELLS; GLYCOPROTEINS; HUMANS; KINETICS; LAMININ; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT PROTEINS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SINGLE-CHAIN ANTIBODIES; VIRAL ENVELOPE PROTEINS; VIRION; VIRUS REPLICATION;

EID: 84938947389     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414754112     Document Type: Article

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